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Current Topics in Microbiology and Immunology pp 1–27Cite as

Expression of Histocompatibility Antigens during the Growth Cycle of Cultured Lymphoid Cells

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 66))

Abstract

Histocompatibility antigens are genetically determined markers which are located on plasma membranes of tissue cells of each member of a species. HL-A antigens are the gene products of the major histocompatibility locus in man and represent the human counterparts of the H-2, Ag-B, ChL-A and DL-A systems in mice, rats, chimpanzees and dogs, respectively (Palm, 1964; Snell and Stimpfling, 1966; Rapaport et al., 1970; Balner et al., 1971; Klein and Shreffler, 1971). The great interest in the serologic, genetic, chemical and immunological characterization of histocompatibility antigens is attributable to the fact they provide cell surface markers useful in selecting transplant donors and recipients. Although at present the role of HL-A antigens in transplantation is widely accepted, a certain degree of skepticism remains mostly among surgeons, largely because of the difficulty in predicting the fate of grafts between unrelated individuals by means of HL-A typing. The more recent interest in HL-A antigens focuses on their function in cell economy as well as on their molecular organization on cell membranes. Because of their strategic location, it appears that histocompatibility antigens may provide an excellent tool in the expanding studies directed towards the characterization of cell membranes. In this approach cultured lymphoid cells may be invaluable because they retain their histocompatibility antigen expression over long periods of time and are available in relatively large amounts (Bernoco et al., 1969; Papermaster et al., 1969; Rogentine and Gerber, 1969, 1970; Klein et al., 1970; Pellegrino et al., 1972b).

This is publication number 793 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California. This work was supported by United States Public Health Service grants AI 10180 and AI 07007 from the National Institutes of Health and grant 70–615 from the American Heart Association, Inc., and from the California Division of the American Cancer Society Senior fellowship number D-221.

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Authors and Affiliations

  1. University of Milan, Italy

    S. Ferrone

  2. Deutsche Forschungsgemeinschaft, University of Mainz, Germany

    M. P. Dierich

  3. Dept. of Molecular Immunology, Scripps Clinic and Research Foundation, 476 Prospect Street, 92037, La Jolla, Cal., USA

    R. A. Reisfeld

Authors
  1. S. Ferrone
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  2. M. A. Pellegrino
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  3. M. P. Dierich
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  4. R. A. Reisfeld
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Editor information

Editors and Affiliations

  1. Basle, Switzerland

    W. Arber  & N. K. Jerne  & 

  2. Freiburg, Germany

    R. Haas

  3. Philadelphia, USA

    W. Henle , P. Koldovský  & H. Koprowski ,  & 

  4. Martinsried, Germany

    P. H. Hofschneider

  5. London, UK

    J. H. Humphrey

  6. Copenhagen, Denmark

    O. Maaløe

  7. Gießen, Germany

    R. Rott

  8. Wilhelmshaven, Germany

    H. G. Schweiger

  9. Rehovot, Israel

    M. Sela

  10. Prague, Czech Republic

    L. Syruček

  11. Seattle, USA

    P. K. Vogt

  12. Würzburg, Germany

    E. Wecker

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© 1974 Springer-Verlag Berlin · Heidelberg

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Ferrone, S., Pellegrino, M.A., Dierich, M.P., Reisfeld, R.A. (1974). Expression of Histocompatibility Antigens during the Growth Cycle of Cultured Lymphoid Cells. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 66. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65908-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-65908-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65910-2

  • Online ISBN: 978-3-642-65908-9

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