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Phleomycin and Bleomycin

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Antineoplastic and Immunosuppressive Agents

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Abstract

Strains of Streptomyces verticillus native to the soil of the coal mining country of Fukuoka Prefecture, Japan can elaborate heterogeneous antibiotic substances (i.e., phleomycin and bleomycin) with a capacity to block DNA synthesis, inhibit proliferation of replicative RNA’s, and prevent higher cells from entering meiotic or mitotic division. These actions can occur separately, possibly because they depend on different specific compounds present in phleomycin and bleomycin. These actions were discovered at different times and in different laboratories during independent investigations. Reported separately, they created a confusing and conflicting literature on the action of phleomycin-bleomycin.

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Authors
  1. Paul Pietsch
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, 20014, Bethesda, Maryland, USA

    David G. Johns M.D.

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© 1975 springer-Verlag Berlin-Heidelberg

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Pietsch, P. (1975). Phleomycin and Bleomycin. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65806-8_49

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  • DOI: https://doi.org/10.1007/978-3-642-65806-8_49

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65808-2

  • Online ISBN: 978-3-642-65806-8

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