Abstract
This agent induces tumors in a variety of organs, most commonly the parotid salivary glands. Adrenal tumors are unilateral or bilateral. They are very soft, fleshy, and pale pink with foci of internal hemorrhage. Their surfaces are smooth and glistening. Large tumors may be multinodular and reach 2.5 cm in diameter. Metastases are often widespread to liver, lungs, ovary, pancreas, and peripheral lymph nodes (Stewart 1955,1960).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Allison AC (1980) Immune responses to polyoma virus and polyoma virus-induced tumors. In: Klein G (ed) Viral oncology. Raven, New York
Barthold SW, Olson C (1974) Papovavirus-induced neoplasia. In: Melby EC Jr Altman NH (eds) Handbook of laboratory animal science, vol II, CRC, Cleveland, chapter 9
Barthold SW, Bhatt PN, Johnson EA (1987) Further evidence for papovavirus as the probable etiology of transmissible lymphoma of Syrian hamsters. Lab Anim Sci 37:283–288
Buffet RF, Levinthal JD (1962) Polyoma virus infection in mice. Arch Pathol 74:513–526
Dubensky TW, Murphy FA, Villarreal LP (1984) Detection of DNA and RNA virus genomes in organ systems of whole mice: patterns of mouse organ infection by polyomavirus. J Virol 50:779–783
Eddy BE (1960) The polyoma virus. Adv Virus Res 7:91–102
Howatson AF, McCulloch EA, Almeida JD, Siminovitch L, Axelrad AA, Ham AW (1960) Studies in vitro, in vivo and by electron microscope of a virus recovered from a C3H mouse mammary tumor: relationship to polyoma virus. JNCI 24:1131–1151
Jones EE, Woodward LJ (1954) Spontaneous adrenal medullary tumors in hybrid mice. JNCI 15:449–461
King NW, Hunt RD, Letvin NL (1983) Histopathologic changes in macaques with an acquired immunodeficiency syndrome (AIDS). Am J Pathol 113:382–388
McCance DJ, Mims CA (1979) Reactivation of polyoma virus in kidneys of persistently infected mice during pregnancy. Infect Immuno 25:998–1002
McCance DJ, Sebesteny A, Griffin BE, Balkwill F, Tilly R, Gregson NA (1983) A paralytic disease in nude mice associated with polyoma virus infection. J Gen Virol 64: 57–67
Rowe WP (1961) The epidemiology of mouse polyoma virus infection. Bacteriol Rev 25:18–31
Sebesteny A, Tilly R, Balkwill F, Trevan D (1980) Demyelination and wasting associated with polyomavirus infection in nude (nu/nu) mice. Lab Anim 14:337–345
Stanton MF, Stewart SE, Eddy BE, Blackwell RH (1959) Oncogenic effect of tissue-culture preparations of polyoma virus on fetal mice. JNCI 23:1441–1475
Stewart SE (1955) Neoplasms in mice inoculated with cell-free extracts or filtrates of leukemic mouse tissues. I. Neoplasms of the parotid and adrenal glands. JNCI 15:1391–1415
Stewart SE (1960) The polyoma virus. Adv Virus Res 7:61–90
Stewart SE, Eddy BE, Borgese N (1958) Neoplasms in mice inoculated with a tumor agent carried in tissue culture. JNCI 20:1223–1243
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Barthold, S.W. (1996). Polyoma Virus Infection, Adrenal, Mouse. In: Jones, T.C., Capen, C.C., Mohr, U. (eds) Endocrine System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60996-1_69
Download citation
DOI: https://doi.org/10.1007/978-3-642-60996-1_69
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64649-2
Online ISBN: 978-3-642-60996-1
eBook Packages: Springer Book Archive