Skip to main content
SpringerLink
Log in

Adenoma, Carcinoma, Parathyroid, Rat

  • Chapter
Endocrine System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

Parathyroid adenomas vary from grossly undetectable to unilateral nodules several millimeters in diameter. They are located in the cervical region embedded under the capsule of the thyroid (Fig. 387) and appear as soft, grayish white, opaque, or pink tissue. Adenomas derived from ectopic parathyroid tissue may be seen infrequently in the thoracic cavity near the base of the heart or in the precardiac mediastinum (Capen et al. 1991).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arnold A, Staunton CE, Kim HG, Gaz RD, Kronenberg HM (1988) Monoclonality and abnormal parathyroid hormone genes in parathyroid adenomas. N Engl J Med 318:658–662

    Article  PubMed  CAS  Google Scholar 

  • Berdjis CC (1972) Parathyroid diseases and irradiation. Strahlentherapie 143:48–62

    PubMed  CAS  Google Scholar 

  • Boorman GA, Hollander CF (1973) Spontaneous lesions in the female Wag/Rij (Wistar) rat. J Gerontol 28:152–159

    PubMed  CAS  Google Scholar 

  • Brown EM, LeBoff MS (1986) Pathophysiology of hyperparathyroidism. Prog Surg 18:13–22

    Google Scholar 

  • Burek JD (1978) Pathology of aging rats. CRC Press, West Palm Beach, pp 38–41

    Google Scholar 

  • Capen CC (1978) Tumors of the endocrine glands. In: Moulton JE(ed) Tumors in domestic animals, 2nd edn. University of California Press, Berkeley, pp 372–429

    Google Scholar 

  • Capen CC (1983) Structural and biochemical aspects of parathyroid gland function in animals. In: Jones TC Mohr U Hunt RD(eds) Monographs on pathology of laboratory animals, endocrine system, 1st edition. Springer, Berlin Heidelberg New York, pp 217–247

    Google Scholar 

  • Capen CC (1989) Neoplasms of the parathyroid glands. In: Stinson SF Reznik G(eds) Atlas of tumor pathology in the F344 rat. CRC Press, Boca Raton, pp 367–378

    Google Scholar 

  • Capen CC, DeLellis RA, Yarrington JT (1991) Endocrine system. In: Haschek WM Rousseaux CG(eds) Handbook of toxicologic pathology. Academic, San Diego, pp 625–760

    Google Scholar 

  • Deerberg F, Rapp KP, Pittermann W, Rehm S (1980) Zum Tumorspektrum der Han: WIST-Ratte. Z Versuchstierkd 22:267–280

    PubMed  CAS  Google Scholar 

  • Fjälling M, Hansson G, Hedman I, Ragnhult I, Tisell LE (1981) Radiation-induced parathyroid adenomas and thyroid tumors in rats. Acta Pathol Microbiol Scand [A] 89:425–429

    Google Scholar 

  • Goodman DG, Ward JM, Squire RA, Chu KC, Linhart MS (1979) Neoplastic and non-neoplastic lesions in aging F344 rats. Toxicol Appl Pharmacol 48:237–248

    Article  PubMed  CAS  Google Scholar 

  • Lindsay S, Potter GD, Chaikoff IL (1957) Thyroid neoplasms in the rat: a comparison of naturally occurring and 1-131-induced tumors. Cancer Res 17:183–189

    PubMed  CAS  Google Scholar 

  • MacKenzie WF, Garner FM (1973) Comparison of neoplasms in six sources of rats. J Natl Cancer Inst 50:1243–1257

    CAS  Google Scholar 

  • Oslapas R, Prinz R, Ernst K, Smith M, Greenlee W, Hofmann C, Lawrence AM, Paloyan E (1981) Incidence of radiationinduced parathyroid tumors in male and female rats. Clin Res 29:734A

    Google Scholar 

  • Pour PM, Wilson JT, Salmasi S (1983) Adenoma, Carcinoma, Parathyroid, Rat. In: Jones TC Mohr U Hunt RD(eds) Monographs on pathology of laboratory animals, endocrine system, 1st edition. Springer, Berlin Heidelberg New York, pp 281–287

    Google Scholar 

  • Prejean JD, Peckham JC, Casey AE, Griswold DP, Weisburger EK, Weisburger JH (1973) Spontaneous tumors in Sprague-Dawley rats and Swiss mice. Cancer Res 33: 2768–2773

    PubMed  CAS  Google Scholar 

  • Rosol TJ, Capen CC (1989) Tumors of the parathyroid gland and circulating parathyroid hormone-related protein associated with persistent hypercalcemia. Toxicol Pathol 17:346–356

    Article  PubMed  CAS  Google Scholar 

  • Rosol TJ, Chew DJ, Capen CC, Sherding RG (1988) Acute hypocalcemia associated with infarction of parathyroid gland adenomas in two dogs. J Am Vet Med Assoc 192: 212–214

    PubMed  CAS  Google Scholar 

  • Seely JC, Hildebrandt PK (1990) Parathyroid gland. In: Boorman GA Eustis SL Elwell MR Montgomery CA Jr MacKenzie WF(eds) Pathology of the Fischer rat, reference and atlas. Academic, San Diego, pp 537–543

    Google Scholar 

  • Snell KC (1965) Spontaneous lesions of the rat. In: Ribelin WE McCoy JR(eds) The pathology of laboratory animals. Thomas, Springfield, pp 284–287

    Google Scholar 

  • Solleveld HA, Haseman JK, McConnell EE (1984) Natural history of body weight gain, survival, and neoplasia in the F344 rat. J Natl Cancer Inst 72:929–940

    PubMed  CAS  Google Scholar 

  • Triggs SM, Williams ED (1977) Irradiation of the thyroid as a cause of parathyroid adenoma. Lancet 1:593–594

    Article  PubMed  CAS  Google Scholar 

  • Warren S, Chute R (1962) Parathyroid carcinoma in parabiont rats. Science 135:927–928

    Article  PubMed  CAS  Google Scholar 

  • Wynford-Thomas V, Wynford-Thomas D, Williams ED (1983) Experimental induction of parathyroid adenomas in the rat. J Natl Cancer Inst 70:127–134

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hannover Medical School, Hannover, Germany

    Kenji Kamino M.D.

  2. Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany

    Heinrich Ernst D.V.M.

  3. Abt. Toxikologie, BASF AG, Ludwigshafen, Germany

    Birgit Kittel Dr.med.vet.

Authors
  1. Kenji Kamino M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Heinrich Ernst D.V.M.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Birgit Kittel Dr.med.vet.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. ILSI Research Foundation, Harvard Medical School, 1126 Sixteenth Street, N.W., Washington, DC, 20036, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology, Emeritus) (Professor of Comparative Pathology, Emeritus)

  2. Department of Veterinary Biosciences, Department of Internal Medicine, College of Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH, 43210-1093, USA

    Charles C. Capen D.V.M., Ph.D. (Professor of Veterinary Pathobiology and Chairman, Professor of Endocrinology) (Professor of Veterinary Pathobiology and Chairman, Professor of Endocrinology)

  3. Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, 30625, Hannover, Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kamino, K., Ernst, H., Kittel, B. (1996). Adenoma, Carcinoma, Parathyroid, Rat. In: Jones, T.C., Capen, C.C., Mohr, U. (eds) Endocrine System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60996-1_41

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60996-1_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64649-2

  • Online ISBN: 978-3-642-60996-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation