Skip to main content
SpringerLink
Log in

C-Cell Hyperplasia, C-Cell Adenoma, and C-Cell Carcinoma, Thyroid, Rat

  • Chapter
Endocrine System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

C-cell hyperplasia and adenoma are usually not visible grossly. C-cell carcinoma may appear as a unilateral or bilateral nodule or irregularly shaped enlargement of the thyroid. When incised, C-cell carcinoma is a moderately firm, uniform, white to tan mass that contrasts sharply with the red-brown color of the normal thyroid parenchyma.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bidard JN, de Nadai F, Rovere C, Moinier D, Laur J, Martinez J, Cuber JC, Kitabgi P (1993) Immunological and biochemical characterization of processing products from the neurotensin/neuromedin N precursor in the rat medullary thyroid carcinoma 6-23 cell line. J Biochem 291:225–233

    CAS  Google Scholar 

  • Birnbaum RS, Muszynski M, Roos BA (1980) Tumor and plasma somatostatin-like immunoreactivity in transplantable rat medullary thyroid carcinoma. Cancer Res 40:4192–4196

    PubMed  CAS  Google Scholar 

  • Black HE, Capen CC, Young DM (1973) Ultimobranchial thyroid neoplasms in bulls. A syndrome resembling medullary thyroid carcinoma in man. Cancer 32:865–878

    Article  PubMed  CAS  Google Scholar 

  • Boorman GA, Hollander CF (1973) Spontaneous lesions in the female WAG/Rij rat. J Gerontol 28:152–159

    PubMed  CAS  Google Scholar 

  • Boorman GA, Hollander CF (1976) Animal model of human disease: medullary carcinoma of the thyroid. Am J Pathol 83:237–240

    PubMed  CAS  Google Scholar 

  • Boorman GA, van Noord MJ, Hollander CF (1972) Naturally occurring medullary thyroid carcinoma in the rat. Arch Pathol 94:35–41

    PubMed  CAS  Google Scholar 

  • Boorman GA, Heersche JNM, Hollander CF (1974) Transplantable calcitonin-secreting medullary carcinomas of the thyroid in the WAG/Rij rat. J Natl Cancer Inst 53:1011–1015

    PubMed  CAS  Google Scholar 

  • Burek JD (1978) Pathology of aging rats. CRC, West Palm Beach

    Google Scholar 

  • Carter WB, Taylor RL, Kao PC, Heath H III, Heath H (1991) Determination of plasma calcitonin gene-related peptide concentrations by a new immunochemiluminometric assay in normal persons and patients with medullary thyroid carcinoma and other neuroendocrine tumors. J Clin Endocrinol Metab 72:327–335

    Article  PubMed  CAS  Google Scholar 

  • Deftos LJ, Boorman GA, Roos BA (1976) Immunoassay of calcitonin in rat medullary thyroid carcinoma. Horm Metab Res 8:83–84

    Article  PubMed  CAS  Google Scholar 

  • Delehaye MC, Cohen R, Segond N, Pidoux E, Treilhou-Lahille F, Milhaud G, Moukhtar MP (1989) Elevated levels of calcitonin mRNA: a marker for the spontaneous development of medullary thyroid carcinoma in rats. Biochem Bioshys Res Commun 159:528–535

    Article  CAS  Google Scholar 

  • DeLellis RA (1994) Changes in structure and function of thyroid C cells. In: Mohr U Dungworth DL Capen CC(eds) Pathobiology of the aging rat. ILSI, Washington DC, pp 285–299

    Google Scholar 

  • DeLellis RA, Nunnemacher G, Wolfe HJ (1977) C-cell hyperplasia. An ultrastructural analysis. Lab Invest 36:237–248

    PubMed  CAS  Google Scholar 

  • DeLellis RA, Nunnemacher G, Bitman WR, Gagel RF, Tashjian AH Jr, Blount M, Wolfe HJ (1979) C-cell hyperplasia and medullary thyroid carcinoma in the rat. An immunohistochemical and ultrastructural analysis. Lab Invest 40:140–154

    PubMed  CAS  Google Scholar 

  • Denijn M, de Weger RA, den Otter W, van Unnik JA, Lips CJ (1992) Expression of the first calcitonin/CGRP gene in spontaneous and transplanted rat medullary thyroid carcinoma: a comparison of dot-blot analysis, in situ hybridization, and immunohistochemistry. J Histochem Cytochem 40:1761–1767

    Article  PubMed  CAS  Google Scholar 

  • Ekholm R, Ericson LE (1968) The ultrastructure of the parafollicular cells of the thyroid gland in the rat. J Ultrastruct Res 23:378–402

    Article  PubMed  CAS  Google Scholar 

  • Emmertsen K (1985) Medullary thyroid carcinoma and calcitonin. Dan Med Bull 32:1–28

    PubMed  CAS  Google Scholar 

  • Goodman DG, Ward JM, Squire RA, Chu KC, Linhart MS (1979) Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol Appl Pharmacol 48:237–248

    Article  PubMed  CAS  Google Scholar 

  • Goodman DG, Ward JM, Squire RA, Paxton MB, Reichardt WD, Chu KC, Linhart MS (1980) Neoplastic and nonneoplastic lesions in aging Osborne-Mendel rats. Toxicol Appl Pharmacol 55:433–447

    Article  PubMed  CAS  Google Scholar 

  • Haller-Brem S, Muff R, Petermann JB, Born W, Roos BA, Fischer JA (1987) Role of cytosolic free calcium concentration in the secretion of calcitonin gene-related peptide and calcitonin from medullary thyroid carcinoma cells. Endocrinology 121:1272–1277

    Article  PubMed  CAS  Google Scholar 

  • Hardisty JF, Boorman GA (1990) Thyroid gland. In: Boorman GA, Eustis SL, Elwell MR, Montgomery CA Jr, MacKenzie WF (eds) Pathology of the Fischer rat. Academic, San Diego, pp 519–536

    Google Scholar 

  • Haseman JK, Arnold J, Eustis SL (1990) Tumor incidences in Fischer 344 rats: NTP historical data. In: Boorman GA, Eustis SL, Elwell MR, Montgomery CA Jr, MacKenzie WF (eds) Pathology of the Fischer rat. Academic, San Diego, pp 555–564

    Google Scholar 

  • Henninger S, Schatz H, Stracke H, Wagner U, Kracht J (1988) Immunohistochemical hormone content in medullary and undifferentiated thyroid carcinoma and prognosis after surgery. Acta Histochem 83:51–56

    Article  PubMed  CAS  Google Scholar 

  • Jokinen MP, Botts S (1994) Tumours of the thyroid gland. In: Turusov V Mohr U(eds) Pathology of tumours in laboratory animals. International Agency for Research on Cancer, Lyon, pp 565–594

    Google Scholar 

  • Le Guellec P, Dumas S, Voile GE, Pidoux E, Moukhtar MS, Treilhou-Lahille F (1993) An efficient method to detect calcitonin mRNA in normal and neoplastic rat C-cells (medullary thyroid carcinoma) by in situ hybridization using a digoxigenin-labeled synthetic oligodeoxyribonucleotide probe. J Histochem Cytochem 41:389–395

    Article  PubMed  Google Scholar 

  • Meissner WA Warren S (eds) (1969)Tumors of the thyroid gland. In: Firminger HI(ed) Atlas of tumor pathology, vol 4, 2nd edn. Armed Forces Institute of Pathology, Bethesda, p 135

    Google Scholar 

  • Milhaud G (1985) Current progress in medullary carcinoma of the thyroid. Int Congr Ser 684:55–58

    Google Scholar 

  • Mohr U (1994) International classification of rodent tumours, part 1. World Health Organization, IARC Science Publication no 122 274

    Google Scholar 

  • Napalkov NP (1990) Tumours of the thyroid gland. In: Turusov VS Mohr U(eds) Pathology of tumours in laboratory animals. International Agency for Research on Cancer, Lyon, pp 539–572

    Google Scholar 

  • O’Briain DS, DeLellis RA, Wolfe HJ, Reichlin S, Bollinger J, Tashjian AH Jr (1979) Somatostatin immunoreactive cells in C cell hyperplasia and medullary thyroid carcinoma. Lab Invest 40:275–276

    Google Scholar 

  • Okimura Y, Kitajima N, Uchiyama T, Yagi H, Abe H, Shakutsui S, Chihara K (1989) Insulin-like growth factor I (IGF-I) production and the presence of IGF-I receptors in rat medullary thyroid carcinoma cell line 6-2 3 (clone 6). Biochem Bioshys Res Commun 161:589–595

    Article  CAS  Google Scholar 

  • Oskam R, Rijksen G, Lips CJ, Staal GE (1985) Enolase isozymes in differentiated and undifferentiated medullary thyroid carcinomas. Cancer 55:394–399

    Article  PubMed  CAS  Google Scholar 

  • Poston GJ, Seitz PK, Townsend CM Jr, Alexander RW, Rajaraman S, Cooper CW, Thompson JC (1987) Calcitonin gene-related peptide: possible tumor marker for medullary thyroid cancer. Surgery 102:1049–1054

    PubMed  CAS  Google Scholar 

  • Zeytinoglu FN, Gagel RF, Tashjian AH Jr, Hammer RA, Leeman SE (1980) Characterization of neurotensin production by a line of rat medullary thyroid carcinoma cells. Proc Natl Acad Sci USA 77:3741–3745

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Gary A. Boorman D.V.M., M.S., Ph.D. (Chief) & Michael R. Elwell D.V.M., Ph.D.

  2. Tufts University School of Medicine, Boston, Massachusetts, USA

    Ronald A. DeLellis M.D. (Professor of Pathology)

Authors
  1. Gary A. Boorman D.V.M., M.S., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ronald A. DeLellis M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael R. Elwell D.V.M., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. ILSI Research Foundation, Harvard Medical School, 1126 Sixteenth Street, N.W., Washington, DC, 20036, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology, Emeritus) (Professor of Comparative Pathology, Emeritus)

  2. Department of Veterinary Biosciences, Department of Internal Medicine, College of Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH, 43210-1093, USA

    Charles C. Capen D.V.M., Ph.D. (Professor of Veterinary Pathobiology and Chairman, Professor of Endocrinology) (Professor of Veterinary Pathobiology and Chairman, Professor of Endocrinology)

  3. Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, 30625, Hannover, Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Boorman, G.A., DeLellis, R.A., Elwell, M.R. (1996). C-Cell Hyperplasia, C-Cell Adenoma, and C-Cell Carcinoma, Thyroid, Rat. In: Jones, T.C., Capen, C.C., Mohr, U. (eds) Endocrine System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60996-1_29

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60996-1_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64649-2

  • Online ISBN: 978-3-642-60996-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation