Abstract
This chapter summarises the various functions of the kidney. Some functions, such as filtration and the endocrine role, will be discussed in some detail here. Other aspects, such as tubule function, will be dealt with in the next two chapters, and the homeostatic role of the kidney is discussed explicitly in the chapters on water and electrolyte balance (Chaps. 76–82). More comprehensive texts on kidney physiology and pathophysiology have been published recently [4,33,34].
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References
Baumann JE, Persson PB, Ehmke H, Nafz B, Kirchheim HR (1992) Role of endothelium-derived relaxing factor in renal autoregulation in conscious dogs. Am J Physiol 263:F208–F213
Brenner BM, Dworkin LD, Ichikawa I (1986) Glomerular filtration. In: Brenner BM, Rector FC (eds) The kidney. Saunders, Philadelphia, pp 124–144
Brenner BM, Ichikawa I, Deen WM (1981) Glomerular filtration. In: Brenner BM, Rector FC (eds) The kidney. Saunders, Philadelphia, pp 289–327
Brenner BM, Rector FC (1991) The kidney, 4th edn. Saunders, Philadelphia, pp 1–2443
Briggs J (1981) The macula densa sensing mechanism for tubuloglomerular feedback. Fed Proc 40:99–103
Cameron S (1993) Renal function testing. In: Cameron S, Davison AM, Grünfeld JP, Kerr D, Ritz E (eds) Oxford textbook clinical nephrology. Oxford University Press, Oxford, pp 24–49
Cameron S, Davison AM, Grünfeld JP, Kerr D, Ritz E (1992) Oxford textbook of clinical nephrology. Oxford University Press, Oxford, pp 1–2348
De Rouffignac C (1990) The urinary concentrating mechanism. In: Kinne RKH (ed) Urinary concentrating mechanisms. Karger, Basel, pp 31–102
Deen WM, Bohrer MP, Brenner BM (1979) Macromolecule transport across glomerular capillaries: application of pore theory. Kidney Int 16:353–362
Deluca HF (1984) The metabolism, physiology and function of vitamin D. In: Kumar R (ed) Vitamin D: basic and clinical aspects. Nijhoff, Boston, pp 1–68
Dworking LD, Brenner BM (1992) Biophysical basis of glomerular filtration. In: Seldin DW, Giebisch G (eds) The kidney: physiology and pathophysiology. Raven, New York, pp 979–1016
Edwards RM (1983) Segmental effects of norepinephrine and angiotensin II on isolated renal microvessels. Am J Physiol 244:F526–F534
Farquar MG (1975) The primary glomerular filtration barrier — basement membrane or epithelial slits. Kidney Int 8:197–205
Folkow B (1990) Salt and hypertension. NIPS 5:220–224
Goormaghtigh N (1939) Existence of an endocrine gland in the media of the renal arterioles. Proc Soc Exp Biol Med 42:688–689
Hebert SC, Kriz W (1993) Structural-functional relationships in the kidney. In: Schrier RW, Gottschalk CW (eds) Diseases of the kidney. Little Brown, Boston, pp 3–64
Jelkmann W (1992) Erythropoietin: structure, control of production, and function. Physiol Rev 72:449–489
Kirchheim HR, Ehmke H, Hackenthal E, Lowe W, Persoon P (1987) Autoregulation of renal blood flow, glomerular filtration rate and renin release in conscious dogs. Pflugers Arch 410:441–449
Kriz W, Kaissling B (1992) Structural organization of the mammalian kidney. In: Seldin DW, Giebisch G (eds) The kidney: physiology and pathophysiology. Raven, New York, pp 707–778
Kurtz A (1990) Do calcium activated chloride channels control renin secretion? NIPS 5:43–46
Mallick NP, Short CD (1993) The clinical approach to haematuria and proteinuria. In: Cameron S, Davison AM, Grünfeld JP, Kerr D, Ritz E (eds) Oxford textbook of clinical nephrology. Oxford University Press, Oxford, pp 227–239
Mene P, Simonson MS, Dunn MJ (1989) Physiology of the mesangial cell. Physiol Rev 69:1347–1423
Pallone TL, Robertson CR, Jamison RL (1990) Renal medullary microcirculation. Physiol Rev 70:885–920
Pavenstädt H, Gloy J, Leipziger J, Klär B, Pfeilschifter J, Schollmeyer P, Greger R (1993) Effect of extracellular ATP on contraction, cytosolic calcium activity, membrane voltage and ion currents of rat mesangial cells in primary culture. Br J Pharmacol 109:953–959
Pfeilschifter J (1989) Cross-talk between transmembrane signalling systems: a prerequisite for the delicate regulation of glomerular haemodynamics by mesangial cells. Eur J Clin Invest 19:347–361
Rennke HG, Cotran RS, Venkatachalam MA (1975) Role of molecular charge in glomerular permeability: tracer studies with cationized ferritins. J Cell Biol 67:638–645
Rosivall L (1991) The role of angiotensin in the control of renal vascular resistance. In: Hatano M (ed) Nephrology. Springer, Berlin Heidelberg New York, pp 731–739
Sands JM, Kokko JP, Jacobson HR (1992) Intrarenal heterogeneity: vascular and tubular. In: Seldin DW, Giebisch G (eds) The kidney: physiology and pathophysiology. Raven, New York, pp 1087–1156
Schlatter E (1993) Effects of various diuretics on membrane voltage of macula densa cells. Whole-cell patch-clamp experiments. Pflugers Arch 423:74–77
Schlatter E, Salomonsson M, Persson AEG, Greger R (1989) Macula densa cells sense luminal NaCl concentration via the furosemide sensitive Na-2Cl-K cotransporter. Pflugers Arch 414:286–290
Schlöndorff D (1987) The glomerular mesangial cell: an expanding role for a specialized pericyte. FASEB J 1:272–281
Schnermann J, Briggs JP (1991) Function of the juxtaglomerular apparatus: control of glomerular hemodynamics and renin secretion. In: Seldin DW, Giebisch G (eds) The kidney: physiology and pathophysiology. Raven, New York, pp 1249–1290
Schrier RW, Gottschalk CW (1993) Diseases of the kidney, 5th edn. Little Brown, Boston, pp 1–3270
Seldin DW, Giebisch G (1992) The kidney: physiology and pathophysiology, 2nd edn. Raven, New York, pp 1–3816
Spivak JL, Watson AJ (1992) Hematopoiesis and the kidney. In: Seldin DW, Giebisch G (eds) The kidney: physiology and pathophysiology. Raven, New York, pp 1553–1593
Steinhausen M, Blum M, Fleming JT, Holz FG, Parekh N, Wiegman DL (1989) Visualization of renal autoregulation in the split hydronephrotic kidney of rats. Kidney Int 35:1151–1160
Taugner R, Hackenthal E (1989) The juxtaglomerular apparatus. Springer, Berlin Heidelberg New York, pp 1–306
Thomas CP, Simonson MS, Dunn MJ (1992) Endothelin: receptors and transmembrane signals. NIPS 7:207–211
Thompson DD, Pitts RF (1952) Effects of alterations of renal artery pressure on sodium and water excretion. Am J Physiol 168:490–499
Vanholder RC, Ringoir SMG (1992) The uraemic syndrome. In: Cameron S, Davison AM, Grünfeld JP, Kerr D, Ritz E (eds) Oxford textbook of clinical nephrology. Oxford University Press, Oxford, pp 1236–1250
Wright FS, Giebisch G (1992) The kidney: Physiology and pathophysiology. In: Seidin DW, Giebisch G (eds) Regulation of potassium excretion. Raven, New York, pp 2209–2248
Zuccelli P, Zuccalà A (1992) Control of blood pressure in patients on haemodialysis. In: Cameron S, Davison AM, Grünfeld JP, Kerr D, Ritz E (eds) Oxford textbook clinical nephrology. Oxford University Press, Oxford, pp 1458–1467
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Greger, R. (1996). Introduction to Renal Function, Renal Blood Flow and the Formation of Filtrate. In: Greger, R., Windhorst, U. (eds) Comprehensive Human Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60946-6_74
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DOI: https://doi.org/10.1007/978-3-642-60946-6_74
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64619-5
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