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Dermatologische Onkologie pp 13–21Cite as

UV-Licht und Kanzerogenese

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Zusammenfassung

Die Exposition der Haut mit ultravioletter Strahlung ist der wichtigste Risikofaktor für die Entwicklung von Plattenepithelkarzinomen, Basaliomen und malignen Melanomen. Die Ausbildung maligner Hauttumore ist, wie auch bei anderen malignen Tumoren, ein Prozess, der in mehreren genetisch determinierten Schritten abläuft (Abb. 2.1). Mit immer mehr genetischen Veränderungen (Mutationen) erwerben betroffene Zellen ganz spezifische Fähigkeiten, die sie zur Progression in ein höheres Tumorstadium befähigen, oder sie verlieren Funktionen, die sie vor Progression schützen. Zellen mit einer ausreichend großen Zahl solcher besonderer, erworbener (bzw. verlorener) biologischer Eigenschaften führen dann auch zu klinisch manifesten prämalignen und malignen Proliferationen.

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Literatur

  1. Alcalay J, Freeman SE, Goldberg LH, Wolf JE (1990) Excision repair of pyrimidine dimers induced by simulated solar irradiation in the skin of patients with basal cell carcinoma. J Invest Dermatol 95: 506–509

    Article  PubMed  CAS  Google Scholar 

  2. Ananthaswamy HN, Pierceall WE (1990) Molecular mechanisms of ultraviolet radiation carcinogenesis. Photochem Photobiol 52: 1119–1136

    Article  PubMed  CAS  Google Scholar 

  3. Autier P, Joarlette M, Lejeune F, Liénard D, André J, Achten G (1991) Cutaneous malignant melanoma and exposure to sunlamps and sunbeds: a descriptive study in Belgium. Melanoma Res 1: 69–74

    Article  PubMed  CAS  Google Scholar 

  4. Autier P, Dorè JF, Schifflers E et al. (1995) Melanoma and use of sunscreens: an EORTC case-control study in Germany, Belgium and France. The EORTC Melanoma Cooperative Group. Int J Cancer 61: 749–755

    Article  PubMed  CAS  Google Scholar 

  5. Baadsgard O, Wulf HC, Lange-Wantzin G, Cooper KD (1987) UVB and UVC, but not UVA, potently induce the appearance of T6-DR+ antigen-presenting cells in human epidermis. J Invest Dermatol 89: 113–118

    Article  Google Scholar 

  6. Barnes DE, Lindahl T, Sedgwick B (1993) DNA repair. Curr Opin Cell Biol 5: 424–433

    Article  CAS  Google Scholar 

  7. Beehler BC, Przybyszewski J, Box HB, Kulesz-Martin MF (1992) Formation of 8-hydroxyguanosine with DNA of mouse keratinocytes exposed in culture to UVB and H2O2. Carcinogenesis 13: 2003–2007

    Article  PubMed  CAS  Google Scholar 

  8. Bestak R, Barnetson RSC, Nearn MR, Halliday GM (1995) Sunscreen protection of contact hypersensitivity responses from chronic solar-simulated ultraviolet irradiation correlates with the absorbtion spectrum of the sunscreen. J Invest Dermatol 105: 345–351

    Article  PubMed  CAS  Google Scholar 

  9. Boiteux S (1993) Properties and biological functions of the NTH and FPG proteins of Escherichia coli: two DNA glycosylases that repair oxidative damage to DNA. J Photochem Photobiol B 19: 87–96

    Article  PubMed  CAS  Google Scholar 

  10. Bootsma D, Hoeijmakers JH (1993) DNA repair. Engagement with transcription. Nature 363: 114–115

    Article  PubMed  CAS  Google Scholar 

  11. Brash DE (1988) UV mutagenic photoproducts in Escherichia coli and human cells: a molecular genetics perspective on human skin cancer. Photochem Photobiol 48: 59–66

    Article  CAS  Google Scholar 

  12. Brash DE, Rudolph JA, Simon JA et al. (1991) A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci USA 88: 10124–10128

    Article  PubMed  CAS  Google Scholar 

  13. Brash DE, Ziegler A, Jonason AS, Simon JA, Kunala S, Leffell DJ (1996) Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. J Invest Dermatol Symp Proc 1: 136–142

    CAS  Google Scholar 

  14. Buratowski S (1993) DNA repair and transcription: the helicase connection (editorial). Science 260: 37–38

    Article  PubMed  CAS  Google Scholar 

  15. Cheng KC, Cahill DS, Kasai H, Sishimura S, Loeb LA (1992) 8-Hydroxy-guanine, an abundant form of oxidative DNA damage, causes G to T and A to C substitutions. J Biol Chem 267: 166–172

    PubMed  CAS  Google Scholar 

  16. Churchill ME, Peak JG, Peak MJ (1991) Repair of near- visible- and blue-light-induced DNA single-strand breaks by CHO cell lines AA8 and EM9. Photochem Photobiol 54: 639–644

    Article  PubMed  CAS  Google Scholar 

  17. Cleaver JE (1968) Defective repair replication of DNA in xeroderma pigmentosum. Nature 218: 652–656

    Article  PubMed  CAS  Google Scholar 

  18. de Gruijl FR, Sterenborg HJCM, Forbes PD et al. (1993) Wavelength dependance of skin cancer induction by ultraviolet irradiation of albino hairless mice. Cancer Res 53: 53–60

    PubMed  Google Scholar 

  19. De Weerd-Kastelein EA, Keijzer W, Bootsma D (1972) Genetic heterogeneity of xeroderma pigmentosum demonstrated by somatic cell hybridization. Nature 238: 80–83

    Google Scholar 

  20. Demple B, Harrison L (1994) Repair of oxidative damage to DNA: enyzmology and biology. Ann Rev Biochem 63: 1

    Article  Google Scholar 

  21. Donawho CK, Kripke ML (1992) Lack of correlation between UV-induced enhancement of melanoma development and local suppression of contact hypersensitivity. Exp Dermatol 1: 20–26

    Article  PubMed  CAS  Google Scholar 

  22. DuBridge RB, Calos MP (1987) Molecular approaches to the study of gene mutation in human cells. Trends in. Genet 3: 293–297

    CAS  Google Scholar 

  23. Elwood JM, Koh HK (1994) Etiology, epidemiology, risk factors, and public health issues of melanoma. Curr Opin Oncol 6: 179–187

    Article  PubMed  CAS  Google Scholar 

  24. Epe B (1991) Genotoxicity of singlet oxygen. Chem Biol Interactions 80: 239–260

    Article  CAS  Google Scholar 

  25. Epe B, Pflaum M, Boiteux S (1993) DNA damage induced by photosensitizers in cellular and cell free systems. Mutat Res 299: 135–145

    Article  PubMed  CAS  Google Scholar 

  26. Foote CS (1991) Definition of type I and type II photosensitized oxidation. Photochem Photobiol 54: 659–663

    Article  PubMed  CAS  Google Scholar 

  27. Fornace AJ, Kohn KW, Kann HE (1976) DNA single strand breaks during repair of UV-damage in human fibroblasts and abnormalities of repair in xeroderma pigmentosum. Proc Natl Acad Sci USA 73: 39–43

    Article  PubMed  CAS  Google Scholar 

  28. Freeman SE, Hacham H, Gange RW, May tum DJ, Sutherland JC, Sutherland BM (1989) Wavelength dependance of pyrimidine dimer formation in DNA of human skin irradiated in situ with ultraviolet light. Proc Natl Acad Sci USA 86: 5605–5609

    Article  PubMed  CAS  Google Scholar 

  29. Gange RW, Rosen CF (1986) UVA effects on mammalian skin and cells. Photochem Photobiol 43: 701–705

    Article  PubMed  CAS  Google Scholar 

  30. Garbe C (1992) Sonne und malignes Melanom. Hautarzt 43: 251–257

    PubMed  CAS  Google Scholar 

  31. Garbe C (1995) Risikofaktoren für die Entwicklung maligner Melanome und Identifikation von Risikopersonen im deutschsprachigen Raum. Hautarzt 46: 309–314

    Article  PubMed  CAS  Google Scholar 

  32. Glover MT, Prober CM, Leigh IM (1993) Skin cancer in renal transplant patients. Cancer Bull 45: 220–224

    Google Scholar 

  33. Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54: 4855–4878

    PubMed  CAS  Google Scholar 

  34. Gutmann M (1993) Malignant melanoma in different genetic groups in Israel. Cancer 71: 2746–2750

    Article  Google Scholar 

  35. Higgins EM, Du Vivier AWP (1992) Possible induction of malignant melanoma by sunbed use. Clin Exp Dermatol 17: 357–359

    Article  PubMed  CAS  Google Scholar 

  36. Hoeijmakers JHJ (1993) Nucleotide exision repair II: from yeast to mammals. Trends Genet 9: 211–217

    Article  PubMed  CAS  Google Scholar 

  37. International Agency for Research on Cancer (1993) IARC monographs on the evaluation of carcinogenic risks to humans; ultraviolet radiation (vol. 55). Lyon, IARC

    Google Scholar 

  38. Kovacs E, Langemann H (1991) Differences in the kinetic of DNA repair in cancer patients and healthy controls. Oncology 48: 312–316

    Article  PubMed  CAS  Google Scholar 

  39. Kraemer KH, Lee MM, Scotto J (1987) Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases (review article). Arch Dermatol 123: 241–250

    Article  PubMed  CAS  Google Scholar 

  40. Kumakiri M, Hashimoto K, Willis I (1977) Biological changes due to long-wave ultraviolet irradiation on human skin: ultra structural study. J Invest Dermatol 69: 392–400

    Article  PubMed  CAS  Google Scholar 

  41. Lundgren K, Wulf HC (1988) Cytotoxicity and genotoxicity of UVA irradiation in Chinese hamster ovary cells measured by specific locus mutations, sister chromatid exchanges and chromosome aberrations. Photochem Photobiol 47: 559–563

    Article  PubMed  CAS  Google Scholar 

  42. Matsui MS, DeLeo VA (1991) Longwave ultraviolet radiation and promotion of skin cancer. J Photochem Photobiol B 3: 281–287

    Google Scholar 

  43. Mitchell D, Nairn RS (1988) The (6–4) photoproduct and human skin cancer. Photodermatol 5: 61–66

    PubMed  CAS  Google Scholar 

  44. National Institutes of Health Consensus Development Conference Statement (1989) Sunlight, Ultraviolet Radiation, and the Skin (vol 7, number 8)

    Google Scholar 

  45. Nelson MA, Einspahr JG, Alberts DS et al. (1994) Analysis of the p53 gene in human precancerous actinic keratosis lesions and squamous cell cancer. Cancer Lett 85: 23–29

    Article  PubMed  CAS  Google Scholar 

  46. Nishigori C, Yarosh DB, Donawho C, Kripke ML (1996) The immune system in ultraviolet carcinogenesis. J Invest Dermatol Symposium Proceedings 1: 143–146

    CAS  Google Scholar 

  47. Pero RW, Johnson DB, Markowitz M et al. (1989) DNA repair synthesis in individuals with and without a family history of cancer. Carcinogenesis 10: 693–697

    Article  PubMed  CAS  Google Scholar 

  48. Pflaum M, Boiteux S, Epe B (1994) Visible light generates oxidative DNA base modifications in high excess of strand breaks in mammalian cells. Carcinogenesis 15: 297–300

    Article  PubMed  CAS  Google Scholar 

  49. Rivers JK, Kelly JW, MacLennan R (1993) The Eastern Australian mole study: constitutional facors and latitude considerations. Melanoma Res 3: 57–58

    Article  Google Scholar 

  50. Rünger TM, Möller K (1994) Molekularbiologische Aspekte der photoinduzierten Hypermutabilität bei Genodermatosen. Akt Dermatol 20: 89–96

    Google Scholar 

  51. Rünger TM, Klein CE, Becker JC, Bröcker EB (1994) The role of genetic instability, adhesion, cell motility, and immune escape mechanisms in melanoma progression. Curr Opin Oncol 6: 188–196

    Article  PubMed  Google Scholar 

  52. Rünger TM (1995) DNA-Schäden in der Haut durch ultraviolette Strahlung. Enstehung, Bedeutung, Beeinflussung. Med Klin [Suppl] 90/1: 22–26

    Google Scholar 

  53. Rünger TM, Epe B, Möller K (1995) Processing of directly and indirectly UV-induced DNA damage in xeroderma pigmentosum cells. J Invest Dermatol 105: 68–73

    Article  Google Scholar 

  54. Rünger TM, Epe B, Möller K (1995) Processing of directly and indirectly uv-induced DNA damage in human cells. In: Garbe C, Schmitz S, Orfanos CE (eds) Recent results in cancer research. Skin cancer (vol. 139; pp 31–42). Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  55. Rünger TM (1995) Gentoxizität, Mutagenität und Karzinogenität von UVA und UVB. Haut und Geschlechtskrankheiten 70: 877–881

    Google Scholar 

  56. Sato M, Nishigori C, Zghal M, Yagi T, Takebe H (1993) Ultraviolet-specific mutations in P53 gene in skin tumors in xeroderma pigmentosum patients. Cancer Res 53: 2944–2946

    PubMed  CAS  Google Scholar 

  57. Schmitz S, Garbe C, Tebbe B, Orfanos CE (1994) Langwellige ultraviolette Strahlung (UVA) und Hautkrebs. Hautarzt 45: 517–525

    Article  PubMed  CAS  Google Scholar 

  58. Schwarz T (1996) Effects of UVA light on the immune system. A settled issue? Eur J Dermatol 6: 227–228

    CAS  Google Scholar 

  59. Setlow RB, Grist E, Thompson K, Woodhead AD (1993) Wavelengths effective in induction of malignant melanoma. Proc Natl Acad Sci USA 90: 6666–6670

    Article  PubMed  CAS  Google Scholar 

  60. Staberg B (1983) The carcinogenic effect of UV-A irradiation. J Invest Dermatol 81: 517–519

    Article  PubMed  CAS  Google Scholar 

  61. Sterenborg HJCM (1990) Tumorigenesis by a long wavelength UVA source. Photochem Photobiol 51: 325–330

    Article  PubMed  CAS  Google Scholar 

  62. Strickland PT (1986) Photocarcinogenesis by near-ultra-violet (UV-A) radiation in Senear mice. J Invest Dermatol 87: 272–275

    Article  PubMed  CAS  Google Scholar 

  63. Swerdlow AJ, English JS, MacKie RM, O’Doherty CJ, Hunter JA, Clark J, Hole DJ (1988) Fluorescence lights, ultraviolet lamps and risk of cutaneous melanoma. Br Med J 297: 647–650

    Article  CAS  Google Scholar 

  64. Tyrrell RM, Pidoux M (1989) Singlet oxygen involvement in the inactivation of cultured human fibroblasts by UVA (334 nm, 365 nm) and near-visible (405 nm) radiations. Photochem Photobiol 49: 407–412

    Article  PubMed  CAS  Google Scholar 

  65. Tyrrell RM, Keyse SM (1990) New trends in photobiology. The interaction of UVA radiation with cultured cells. J Photochem Photobiol B 4: 349–361

    Article  PubMed  CAS  Google Scholar 

  66. Van Weelden H, Gruijl FR de, Putter SCJ van der, Toonstra J, Leun JC van der (1988) The carcinogenic risks of modern tanning equipment: is UV-A safer than UV-B? Arch Dermatol Res 280: 300–307

    Article  PubMed  Google Scholar 

  67. Walter SD, Marrett LD, From L, Hertzman C, Shannon HS, Roy P (1990) The association of cutaneous malignant melanoma with the use of sunbeds and sunlamps. Am J Epidemiol 131: 232–243

    PubMed  CAS  Google Scholar 

  68. Wei Q, Matanoski GM, Farmer ER, Hedayati MA, Grossman L (1993) DNA repair and aging in basal cell carcinoma: A molecular epidemiology study. Proc Natl Acad Sci USA 90: 1614–1618

    Article  PubMed  CAS  Google Scholar 

  69. Westerdahl J, Olssson H, Masbâck A et al. (1994) Use of sunbeds or sunlamps and malignant melanoma in Southern Sweden. Am J Epidemiol 140: 691–699

    PubMed  CAS  Google Scholar 

  70. Westerdahl J, Olsson H, Masback A, Ingwar C, Jonsson N (1995) Is the use of sunscreens a risk factor for malignant melanoma? Melanoma Res 5: 59–65

    Article  PubMed  CAS  Google Scholar 

  71. Yoshikawa T, Rae V, Bruins-Slot W, Berg JW van den, Taylor JR, Streilein JW (1990) Susceptibility to effects of UVB radiation on induction of contact hypersensitivity as a risk factor for skin cancer in humans. J Invest Dermatol 95: 530–536

    Article  PubMed  CAS  Google Scholar 

  72. Young AR (1990) Cumulative effects of ultraviolet radiation on the skin: cancer and photoaging. Semin Dermatol 9: 25–31

    PubMed  CAS  Google Scholar 

  73. Ziegler A, Leffell DJ, Kunala S et al. (1993) Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proc Natl Acad Sci USA 90: 4216–4220

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Thomas M. Rünger
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Editors and Affiliations

  1. Sektion für Dermatologische Onkologie, Universitäts-Hautklinik Tübingen, Liebermeisterstraße 25, 72076, Tübingen, Germany

    Claus Garbe

  2. Dermatologische Klinik, Universitätsspital Zürich, Gloriastraße 31, CH-8091, Zürich, Switzerland

    Reinhard Dummer

  3. Zentrum der Dermatologie und Venerologie, Klinikum der Johann-Wolfgang von Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany

    Roland Kaufmann

  4. Universitäts-Hautklinik und Poliklinik Universität des Saarlandes, 66421, Homburg/Saar, Germany

    Wolfgang Tilgen

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© 1997 Springer-Verlag Berlin Heidelberg

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Rünger, T.M. (1997). UV-Licht und Kanzerogenese. In: Garbe, C., Dummer, R., Kaufmann, R., Tilgen, W. (eds) Dermatologische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60622-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-60622-9_2

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  • Print ISBN: 978-3-642-64480-1

  • Online ISBN: 978-3-642-60622-9

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