Skip to main content
SpringerLink
Log in

Muscle-Invasive Bladder Cancer: Transurethral Resection and Radiochemotherapy as an Organ-Sparing Treatment Option

  • Chapter
Carcinoma of the Bladder

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Up to 80% of all transitional cell carcinomas of the urinary bladder are found to be superficial at the time of diagnosis (Ta-T1). In spite of a 50% recurrence rate and a 10%–15% progression rate, these tumors can be controlled adequately by transurethral resection (TURB) and intravesical chemotherapy or immunotherapy. However, poorly differentiated T1 tumors and muscle-invasive tumors (>T2) require a more aggressive treatment approach.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abradt RP, Pontin AR, Barnes RD (1993) Chemotherapy versus radical irradiation plus salvage-cystectomy for bladder cancer severe late small bowel morbidity. Eur J Surg Oncol 19: 279–282

    Google Scholar 

  • Birkenhake S, Sauer R, Kühn R, Martus P, Wittekind C, Schrott KM (1997) Effekte der simultan zur Radiotherapie applizierten Chemotherapie bei der Primärtherapie des muskelinvasiven Blasenkarzinoms. Strahlenther Onkol 173;••-••

    Google Scholar 

  • Blandy JP, England HR, Evans SJW, Hope-Stone HF, Mair GM, Mantell BS, Oliver RT (1980) T3 bladder cancer–the case for salvage cystectomy. Br J Urol 52: 506–510

    Article  PubMed  CAS  Google Scholar 

  • Bloom HJG, Hendry WF, Wallace DM, Skeot RG (1982) Treatment of T3 bladder cancer: controlled trial of pre-operation radiotherapy and radical cystectomy versus radical radiotherapy. Br J Urol 54: 136–151

    Article  PubMed  CAS  Google Scholar 

  • Cervak J, Cufer T, Kragelj B, Zakotnik B, Stanonik M (1993) Sequential transurethral surgery, multiple drug chemotherapy and radiation therapy for invasive bladder carcinoma: initial report. Int J Radiat Biol Phys 25: 777–782

    Article  Google Scholar 

  • Chauvet B, Brewer J, Felix-Faire C, Davin JL, Viecet P, Rebrul F (1993) Combined radiation therapy and cisplatin for locally advanced carcinoma of the urinary bladder. Cancer 72: 2213–2218

    Article  PubMed  CAS  Google Scholar 

  • Coppin C, Cospordarowicz M, Dixon P (1992) Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or radical radiation. Proc Am Soc Clin Oncol 11: 198–201

    Google Scholar 

  • De Neve W, Lybeert ML, Goor C, Crommelin MA, Ribot JG (1995) Radiotherapy for T2 and T3 carcinoma of the bladder: the influence of overall treatment time. Radiother Oncol 36: 183–188

    Article  PubMed  Google Scholar 

  • Duncan W, Quilty W (1986) The result of a series of 963 patients with transitional cell carcinoma of the urinary bladder primarily treated by radical megavoltage X-tray therapy. Radiother Oncol 7: 299–310

    Article  PubMed  CAS  Google Scholar 

  • Dunst J, Sauer R, Schrott KM, Kühn R, Wittekind C, Altendorf-Hofmann A (1994) Organ sparing treatment of advanced bladder cancer. A 10 year experience. Int J Radiat Oncol Biol Phys 30: 261–266

    Article  PubMed  CAS  Google Scholar 

  • Dunst J (1991) Die Radiotherapie im interdisziplinären Behandlungskonzept des Harnblasenkarzinoms. Strahlenther Onkol 167: 563–580

    PubMed  CAS  Google Scholar 

  • Fung CY, Shipley WU, Young RH, et al. (1991) Prognostic factors in invasive bladder carcinoma in a prospective trial of preoperative adjuvant chemotherapy and radiotherapy. J Clin Oncol 9: 1533–1542

    PubMed  CAS  Google Scholar 

  • Goodman GD, Hilop TG, Elvord JM, Balfour J (1981) Conservation of bladder function in patients with invasive bladder cancer treated by definitive irriadiative and selective cystectomy. Int J Radiol Oncol Biol Phys 7: 569–573

    Article  CAS  Google Scholar 

  • Gospodarowicz MK, Hawkins MV, Rawlings GA, et al. (1989) Radical radiotherapy for muscle invasive transitional cell carcinoma of the bladder: failure analysis. J Urol 142: 1448–1454

    PubMed  CAS  Google Scholar 

  • Housset M, Maulard C, Chretien Y, et al. (1993) Combined radiation and chemotherapy for invasive transitional-cell carcinoma of the bladder: a prospective study. J Clin Oncol 11: 2150–2157

    PubMed  CAS  Google Scholar 

  • Jahnson S, Petersen J, Westman G (1991) Bladder carcinoma–a 20 year review of radical irradiation therapy. Radiother Oncol 22: 111–117

    Article  PubMed  CAS  Google Scholar 

  • Jakse G, Frommhold N, Nedden D (1985) Combined radiation and chemotherapy for locally advanced transitional cell carcinoma of the urinary bladder. Cancer 55: 1659–1664

    Article  PubMed  CAS  Google Scholar 

  • Jenkins BJ, Caulfield MJ, Fowler CG, et al. (1988) Reappraisal of the role of radical radiotherapy and salvage cystectomy in the treatment of invasive (T2/T3) bladder cancer. Br J Urol 62: 343–346

    Article  PubMed  CAS  Google Scholar 

  • Jung P, Jakse G (1996) Bladder preservation in invasive locally confined bladder cancer. Onkologie 19: 296–301

    Article  Google Scholar 

  • Kachnic LA, Kaufman DS, Zietman AI, et al. (1995) Selective bladder preservation by combined modality therapy for invasive bladder cancer. Int J Radiat Oncol Biol Phys 32 (Suppl): 271

    Google Scholar 

  • Kaufman DS, Shipley WU, Griffin PP, Heney NM, Althanter AF, Eford JG (1993) Selective bladder preservation by combination treatment of invasive bladder cancer. N Engl J Med 329: 1377–1381

    Article  PubMed  CAS  Google Scholar 

  • Koiso K, Shipley W, Keuppens F, et al. (1995) The status of bladder-preserving therapeutic strategies in the management of patients with muscle-invasive bladder cancer. Int J Urol (Jpn) 2 (Suppl 2): 49–57

    Article  Google Scholar 

  • Mameghan H, Fisher R, Mameghan J, Brook S (1995) Analysis of failure following definitive radiotherapy for invasive transitional cell carcinoma of the bladder. Int J Radiat Oncol Biol Phys 31: 247–254

    Article  PubMed  CAS  Google Scholar 

  • Martinez-Pineiro JA, Gonzalez M, Arocena F, Flores N, Roncero CR, Portillo JA, Escudero A (1995) Neoadjuvant cisplatin chemotherapy before radical cystectomy in invasive transitional cell carcinoma of the bladder: a prospective randomized phase III study. J Urol 153: 964–973

    Article  PubMed  CAS  Google Scholar 

  • Miller LS, Johnson DE (1973) Megavoltage irradiation for bladder cancer. Cancer 10: 771–782

    Google Scholar 

  • Pagano F, Bassi P, Galetti TP (1991) Results of contemporary radical cystectomy for invasive bladder cancer: a clinicopathological study with emphasis on the inadequacy of the tumor, nodes and metastases classification. J Urol 145: 45–49

    PubMed  CAS  Google Scholar 

  • Quilty PM, Duncan W (1985) Primary radical radiotherapy for T3 transitional cell cancer of the bladder: an analysis of survival and control. Int J Radiat Oncol Biol Phys 12: 853–860

    Google Scholar 

  • Rebischung JC, Vannetzel JM, Fournier F (1992) Cyclic concomitant chemoradiotherapy for invasive bladder cancer: phase 2 study with organ preservation. Proc Am Soc Clin Oncol 11: 208–214

    Google Scholar 

  • Rhagavan D, Shipley WU, Garnick MB, Russel PM, Richie JP (1990) Biology and management of bladder cancer. N Engl J Med 322: 1129–1138

    Article  Google Scholar 

  • Rotman M, Macchia R, Silverstein R (1987) Treatment of advanced bladder cancer with irradiation and concomitant 5fluorouracil infusion. Cancer 59: 710–715

    Article  PubMed  CAS  Google Scholar 

  • Russel KJ, Boileau MA, Higano C, et al. (1990) Combined 5fluorouracil and irradiation for transitional cell carcinoma of the urinary bladder. Int J Radiat Oncol Biol Phys 19: 693–699

    Article  Google Scholar 

  • Sauer R, Dunst J, Altendorf-Hofmann A, Fischer H, Bornhof C, Schrott KM (1990) Radiotherapy with and without cisplatin in bladder cancer. Int J Radiat Oncol Biol Phys 19: 687–691

    Article  PubMed  CAS  Google Scholar 

  • Sauer R, Birkenhake S, Martus P (1996) Efficacy of radiochemo-therapy with platin-derivatives compared to radiotherapy alone in organ sparing treatment of bladder cancer. Int J Radiat Oncol Biol Phys 36 (Suppl): 142

    Google Scholar 

  • Scher H, Herr H, Sternberg C, et al. (1989) Neo-adjuvant chemotherapy for invasive bladder cancer. Experience with the M-VAC regimen. Br J Urol 64: 250–256

    Article  PubMed  CAS  Google Scholar 

  • Sell A, Jakobsen A, Nerstrom B, Sorensen BL, Steven K, Barlebo H (1991) Treatment of advanced bladder cancer category T2, T3 and T4a. A randomized multicenter study of preoperative irradiation and cystectomy versus radical irradiation and early salvage cystectomy for residual tumor. DAVECA protocol 8201. Danish Vesical Cancer Group. Scand J Urol Nephrol (Suppl) 138: 193–201

    CAS  Google Scholar 

  • Shearer RJ, Chilvers CE, Bloom HJ, Horwich A, Batiker H (1988) Adjuvant chemotherapy in T3 carcinoma of the bladder. Br J Urol 62: 558–564

    Article  PubMed  CAS  Google Scholar 

  • Shipley WU, Prout GR, Einstein AB, et al. (1987) Treatment of invasive bladder cancer by cisplatin and radiation in patients unsuited for surgery. JAMA 258: 931–935

    Article  PubMed  CAS  Google Scholar 

  • Skinner DG, Lieskovsky G (1988) Management of invasive and high grade bladder cancer. In: Diagnosis and management of genitourinary cancer. Saunders, Philadelphia, p 295

    Google Scholar 

  • Smaaland R, Aksilen LA, Tonder B, et al. (1991) Radical radiation therapy of invasive and locally advanced bladder carcinoma in elderly patients. Br J Urol 67: 61–69

    Article  PubMed  CAS  Google Scholar 

  • Stöckle M, Riedmüller H, Hohenfellner R (1991) Radikale Zystektomie–oft zu spät? Therapieergebnisse der radikalen Zystektomie mit and ohne adjuvante oder induktive M-VAC Behandlung. In: Hartung R, Hübner W, Kropp W (ed) Urologische Beckenchirurgie. Springer, Berlin Heidelberg New York, pp 279–287

    Google Scholar 

  • Tester W, Porter A, Asbell S, et al. (1993) Combined modality program with possible organ preservation for invasive bladder carcinoma: results of RTOG protocol 85–12. Int J Radiat Oncol Biol Phys 25: 783–790

    Article  PubMed  CAS  Google Scholar 

  • Whitmore WF, Batata MA, Thoneim MA, Grabstald H, Unal A (1988) Radical cystectomy with or without prior irradiation in the treatment of bladder cancer. J Urol 139: 299A

    Google Scholar 

  • Wishnow KI, Levinson AK, Johnson DE (1992) Stage B (T2/ 3aNO) transitional cell carcinoma of the bladder highly curable by radical cystectomy. Urology 39: 1–9

    Article  Google Scholar 

  • Zietman AL, Shipley WU, Kaufman DS (1993) The combination of cisplatin based chemotherapy and radiation with treatment of muscle invading transitional cell cancer of the bladder. Int J Radiat Oncol Biol Phys 27: 161–170

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universitätsstrasse 27, D-91054, Erlangen, Germany

    R. Sauer MD (Professor, Direktor der Universitäts-Strahlenklinik)

  2. Universitäts-Strahlenklinik, Universitätsstrasse 27, D-91054, Erlangen, Germany

    S. Birkenhake MD

  3. Urologische Universitätsklinik, Maximiliansplatz 5, D-91054, Erlangen, Germany

    R. Kühn MD (Privat-Dozent)

  4. Liebigstrasse 6, D-04103, Leipzig, Germany

    C. Wittekind MD (Professor, Direktor des Pathologischen Instituts der Universität)

  5. Institut für Medizinische Dokumentation und Statistik der Universität, Waldstrasse 6, D-91054, Erlangen, Germany

    P. Martus MD (Privat-Dozent)

  6. Dryanderstrasse, D-06097, Halle/Saale, Germany

    J. Dunst MD (Professor, Direktor der Universitäts-Strahlenklinik)

  7. Maximiliansplatz 5, D-91054, Erlangen, Germany

    K. M. Schrott MD (Professor, Direktor der Urologischen Universitätsklinik)

Authors
  1. R. Sauer MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Birkenhake MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Kühn MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Wittekind MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Martus MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. Dunst MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. K. M. Schrott MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, University of Southern California, USC/Norris Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA, 90033, USA

    Zbigniew Petrovich MD, FACR (Professor and Chairman) (Professor and Chairman)

  2. Department of Urology, UZ Gasthuisberg, University of Leuven, Herestraat 49, B-3000, Leuven, Belgium

    Luc Baert MD, PhD (Professor and Chairman) (Professor and Chairman)

  3. Department of Radiation Oncology and Nuclear Medicine, Allegheny University Hospitals, Center City, Mail Stop 200, Broad & Vine Sts., Philadelphia, PA, 19102-1192, USA

    Luther W. Brady MD (Professor) (Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Sauer, R. et al. (1998). Muscle-Invasive Bladder Cancer: Transurethral Resection and Radiochemotherapy as an Organ-Sparing Treatment Option. In: Petrovich, Z., Baert, L., Brady, L.W. (eds) Carcinoma of the Bladder. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60258-0_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60258-0_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64323-1

  • Online ISBN: 978-3-642-60258-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation