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Effector and Regulatory Lymphoid Cells and Cytokines in Mucosal Sites

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Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 236))

Abstract

The key feature of the mucosal immune system is the dual ability to respond promptly and effectively to invasive and lumen-dwelling pathogens, while retaining the ability to be unresponsive to non-pathogenic agents such as the autochthonous flora and foods. To specifically ignore some antigens in the gut (i.e. foods) and respond to others (i.e. cholera vibrios) is not an option, since there is no way in which the immune system can predict the nature of a pathogen. The enormous diversity of potential T-cell receptors, therefore, means that all foreign peptides in the gut are likely to be recognised. One of the major goals of modern immunology is to ascertain the determinants which can predict whether recognition results in active immunity or unresponsiveness, and nowhere is this more important than in the gastrointestinal tract.

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  1. Department of Paediatric Gastroenterology, St Bartholomews and the Royal London School of Medicine and Dentistry, St Bartholomews Hospital, London, EC1A 7BE, UK

    T. T. MacDonald

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  1. Swiss Institute for Experimental Cancer Research Institute of Biochemistry, University of Lausanne, Ch. des Boveresses 155, CH-1066, Epalinges, Switzerland

    Jean-Pierre Kraehenbuhl

  2. GI Cell Biology Laboratory, Children’s Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA

    Marian R. Neutra

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© 1999 Springer-Verlag Berlin Heidelberg

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MacDonald, T.T. (1999). Effector and Regulatory Lymphoid Cells and Cytokines in Mucosal Sites. In: Kraehenbuhl, JP., Neutra, M.R. (eds) Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines. Current Topics in Microbiology and Immunology, vol 236. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59951-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-59951-4_7

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