Abstract
Opportunistic infection of the central nervous system by human Polyomavirus JC (JCV) can cause a devastating disease, progressive multifocal leukoencephalopathy (PML). We reviewed the clinical features of 15 patients with acquired immune deficiency syndrome (AIDS) and PML who came to autopsy or biopsy between 1983 and 1990, and investigated brain tissue with conventional and modern molecular biology techniques.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brooks BR, Walker DL (1984) Progressive multifocal leukoenephalopathy. Neurol Clin 2: 299 - 313
Aström KE, Mancali EL, Richardson EP (1958) Progressive multifocal leukoencephalopathy. Brain 81: 93 - 111
Einsiedel von RW, Fife TD, Aksamit AJ, Cornford ME, Secor DL, Tomiyasu U, Itabashi HH, Vinters HV (1993) Progressive multifocal leukoencephalopathy in AIDS: a clinicopathologic study and review of the literature. J Neurol 240: 391–406
Aksamit AJ, Mourrain P, Sever JL, Major EO (1985) Progressive multifocal leukoencephalopathy: investigation of three cases using in situ hybridization with JC virus biotinylated DNA probe. Ann Neurol 18: 490–496.
Houff SA, Major E, Katz DA, Kufta CV, Sever JL, Pittaluga S, Roberts JR, Gitt J, Saini N, Lux W (1988) Involvement of JC virus-infected mononuclear cells from the bone marrow and spleen in the pathogenesis of progressive multifocal leukoencephalopathy. N Engl J Med 318: 301 - 305
Nuovo GJ, Gallery F, MacConnell P, Becker J, Bloch W (1991a) An improved technique for the in situ detection of DNA after polymerase chain reaction amplification. Ain J Pathol 139: 1239–1244
Bagasra O, Hauptman SP, Lischner HW, Sachs M, Pomerantz RJ (1992) Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction. N Engl J Med 326: 1385–1391
ZuRhein GM and Chou SM (1965) Particles resembling papova viruses in human cerebral demy- elinating disease. Science 148: 1477–1479
Samorei IW, Schmid M, Pawlita M, Vinters HV, Diebold K, Mündt Ch, von Einsiedel RW (1999) High sensitivity detection of JC-virus DNA in postmortem brain tissue by in situ PCR. (in press)
Cummings JL, Benson DF (1984) Subcortical dementia: review of an emerging concept. Arch Neurol 41: 874–879
Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Cleary P (1988) The brain in AIDS: central nervous system HIV infection and AIDS dementia complex. Science 239: 586 - 592
Richardson EP (1961) Progressive multifocal leukoencephalopathy. N Engl J Med 265: 815– 823
Anders KH, Guerra WF, Tomiyasu U, Verity MA, Vinters HV (1986) The neuropathology of AIDS. UCLA experience and review. Am J Pathol 124: 537–558
Wiley CA, Gräfe M, Kennedy C, Nelson JA (1988) Human immunodeficiency virus (HIV) and JC virus in aquired immunodeficiency syndrome ( AIDS) patients with progressive multifocal leukoencephalopathy. Acta Neuropathol (Berl) 76: 338–346
Vazeux R, Cumont M, Girard PM, Nassif X, Trotot P, Marche C, Matthiessen L, Vedrenne C, Mikol J, Henin D, Katlama C, Bolgert F, Montagnier L (1990) Severe encephalitis resulting from coinfection with HIV and JC virus. Neurology 40: 944 - 948
Berger JR, Kaszovitz B, Post MJ, Dickinson G (1987) Progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection: a review of the literature with a report of sixteen cases. Ann Intern Med 107: 78 - 87
Krupp LB, Lipton RB, Swerdlow ML, Leeds NE, Llena J (1985) Progressive multifocal encephalopathy: clinical and radiographic features. Annals of Neurology 17: 344 - 349
von Einsiedel RW, Minami E, Secor DL, Pang S, Chen ISY, Vinters HV (1990) Structural components of the AIDS dementia complex: correlation of brain parenchymal astrogliosis with HIV-1 DNA in cerebral tissues. J Neuropathol Exp Neurol 49: 351
Pang S, Koyanagi Y, Miles S, Vinters HV, Chen ISY (1990) High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients. Nature 343: 85 - 89
Chesters PM, Heritage J, McCance DJ (1983) Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues. J Infect Dis 147: 676 - 684
Mori M, Kurata H, Tajima M, Shimada H (1991) JC virus detection by in situ hybridization in brain tissue from elderly patients. Ann Neurol 29: 4287–432
Boldorini R, Cristina S, Vago L, Tosoni A, Guzzetti S, Costanzi G (1993) Ultrastructural studies in the lytic phase of progressive multifocal leukoencephalopathy in AIDS patients. Ultrastruct Pathol 17: 599–609
Kepes J, Chou S, Price LJ (1975) Progressive leukoencephalopathy with 10 year survival in a patient with nontropical sprue: report of a case with unusual light and electron microscopic features. Neurology 25: 1006–1012
Weber T, Major EO (1997b) Progressive multifocal leukoencephalopathy: molecular biology, pathogenesis and clinical impact. Intervirology 40: 98–111
von Einsiedel RW, Samorei IW, Pawlita M, Deubel ML, Mündt Ch, Schmid M, Vinters HV (1999) New JCV infection patterns by in situ PCR in different intracerebral cell types of AIDS patients with PML. Submitted
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
von Einsiedel, R.W., Samorei, I.W., Pawlita, M., Deubel, M., Mundt, C., Vinters, H.V. (2000). Clinical and Neuropathological Features in AIDS Patients with Progressive Multifocal Leukoencephalopathy (PML) Including a Novel Approach by in situ PCR. In: Brockmeyer, N.H., Hoffmann, K., Reimann, G., Stücker, M., Altmeyer, P., Brodt, R. (eds) HIV-Infekt. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59683-4_93
Download citation
DOI: https://doi.org/10.1007/978-3-642-59683-4_93
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64082-7
Online ISBN: 978-3-642-59683-4
eBook Packages: Springer Book Archive