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Effects of CpG DNA on Th1/Th2 Balance in Asthma

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Book cover Immunobiology of Bacterial CpG-DNA

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 247))

Abstract

Asthma is a disease whose prevalence, morbidity, mortality, and cost have increased in the past two decades worldwide. These changes have led to increased attention to the causes of asthma and asthma exacerbations; it is now appreciated that airway inflammation is central to the problem of asthma. Recent international guidelines for the management of asthma emphasize that anti-inflammatory therapies are necessary for most asthma patients, and this focus is slowly improving compliance from asthmatics and their health-care providers. Unfortunately, current anti-inflammatory treatment in asthma is non-specific. In this chapter, the Th1/Th2 paradigm of inflammation, which may govern the eosinophilic inflammation found in asthma, is described. Data are presented that demonstrate that CpG oligodeoxynucleotides (ODN) are capable of modulating the Th2-mediated inflammatory response in a murine model of asthma. These studies suggest that CpG DNA may be useful in the prevention and treatment of asthma.

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Authors and Affiliations

  1. Division of Pulmonary Medicine, University of Iowa College of Medicine, C33GH UIHC, 200 Newton Drive, Iowa City, IA, 52242, USA

    J. N. Kline

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  1. J. N. Kline
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Editors and Affiliations

  1. Institut für Medizinische Mikrobiologie, Immunologie und Hygiene der Technischen Universität München, Trogerstr. 9, D-81675, München, Germany

    Hermann Wagner Ph.D.

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Kline, J.N. (2000). Effects of CpG DNA on Th1/Th2 Balance in Asthma. In: Wagner, H. (eds) Immunobiology of Bacterial CpG-DNA. Current Topics in Microbiology and Immunology, vol 247. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59672-8_15

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  • DOI: https://doi.org/10.1007/978-3-642-59672-8_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64077-3

  • Online ISBN: 978-3-642-59672-8

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