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Treatment

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Madkour’s Brucellosis

Abstract

Treatment of brucellosis is still far from ideal. Even in the presence of effective antibiotics, their side effects remain a major concern to treating clinicians. Selecting the correct antibiotics and the duration of treatment remains problematic. Therapeutic failure, relapses and the development of resistant Brucella strains are among the problems faced during management. Monotherapy has been abandoned because of the unacceptably high rates of therapeutic failure and relapses. Doxycycline-streptomycin (DS) remains the most effective first-line regimen. Single daily dosing (SDD) of netilmicin and gentamicin appears to be promising in the treatment of brucellosis. Liposomes as vehicle for aminoglycosides to target phagocytic cells infected with Brucella organisms are being investigated. Alternative regimens are available, but, though effective, they are associated with higher rates of therapeutic failure and relapses than DS. Patients with serious localizations may require a three-antibiotic regimen and a longer duration of treatment. Surgery may be required in combination with medical treatment in some patients.

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References

  • Abramson, O., Abu Rashid, M., Gorodischer, R. and Yagupsky, R (1997) Failure of short antimicrobial treatments for human brucellosis (letter). Antimicrob Agents Chemother., 41, 1621–1622.

    PubMed  CAS  Google Scholar 

  • Acocella, G., Bertrand, A., Beytout, J., Durrande, J. B., Garcia Rodriguez, J. A., Kosmidis, J., Micoud, M., Rey, M., Rodriguez Zapata, M., Roux, J., et al (1989). Comparison of three different regimens in the treatment of acute brucellosis: a multicenter multinational study. J Antimicrobial Chemother., 23, 433–439.

    CAS  Google Scholar 

  • Akova, M., Uzun, O., Akalin, H.E., Hayran, M., Unal, S. and Gur, D. (1993) Quinolones in treatment of human brucellosis: comparative trial of ofloxacinrifampicin versus doxycycline-rifampicin. Antimicrob Agents Chemother., 37, 1831–1834.

    PubMed  CAS  Google Scholar 

  • Al Eissa, Y.A., Kambal, A.M., Al Nasser, M.N., Al Habib, S. A., Al Fawaz, I.M. and Al Zamil, F.A. (1990) Childhood brucellosis: a study of 102 cases. Pediatr Infect Dis., 9, 74–79.

    Google Scholar 

  • Al Eissa, Y.A., Kambal, A.M., Arabeeah, A. A., Abdullah, A.M., Al Jurayyan, N.A. and Al Jishi, N.M. (1990) Osteoarticular brucellosis in children. Ann Rheum Dis (England), 49, 896–900.

    Google Scholar 

  • Al Harthi, S.S. (1989) The morbidity and mortality pattern of Brucella endocarditis. Int J Cardiol (Netherlands), 25, 321–324.

    Google Scholar 

  • Al Idrissi, H.Y., Uwaydah, A.K., Danso, K.T., Qutub, H. and Al Mousa, M.S. (1989) Ceftriaxone in the treatment of acute and subacute human brucellosis. J Int Med Res (England), 17, 363–368.

    Google Scholar 

  • Al Jubair, K. et al (1992) Cardiac operations during active endocarditis. J. Thorac Cardiovasc Surg., 104, 487–490.

    PubMed  Google Scholar 

  • Al Kasab, S., Al Fagih, M. R., Al Yousef, S. et al (1988) Brucella infective endocarditis. Successful combined medical and surgical therapy. J. Thorac Cardiovasc Surg., 95, 862–867.

    Google Scholar 

  • Al Sibai, M.B. and Qadri, S.M. (1990) Development of ciprofloxacin resistance in Brucella melitensis (letter). J Antimicrobiob Chemother., 25, 302–303.

    Google Scholar 

  • Al Sibai, M.B., Halim, M.A., El Shaker, M.M., Khan, B.A. and Qadri, S.M. (1991) Efficacy of ciprofloxacin for treatment of Brucella melitensis infections. Antimicrob Agents Chemother (United States), 36, 150–152.

    Google Scholar 

  • Al-Eissa, Y.A., Al Zamil, F. A. and Al Nasser, M.N. (1994) Duration of chemotherapy for childhood brucellosis (letter; comment). Pediatr Infect Dis J., 13, 335–336.

    Google Scholar 

  • Alestig, K. (1973) Studies on doxycycline during intravenous and oral treatment with reference to renal function. Scand. J. Infect. Dis., 5, 193–198.

    PubMed  CAS  Google Scholar 

  • Ali, M.Z. and Goetz, M.D. (1997) A meta-analysis of the relative efficacy and toxicity of single daily dosing versus multiple daily dosing of aminoglycosides. Clin Infect Dis., 24, 796–809.

    PubMed  CAS  Google Scholar 

  • Alvarez, S., De Maria, A., Kulkani, R., Klein, J. and McCabe, W.R. (1982) Interactions of rifampicin and trimethoprim in vitro. Rev. Infect. Dis., 4, 390–401.

    PubMed  CAS  Google Scholar 

  • Anticancer Chemotherapy, Proceedings of the 6th International Congress of Chemotherapy, University of Tokyo Press, Tokyo, pp. 339–342.

    Google Scholar 

  • Arioli, V., Pallanza, R., Nicolis, F.B. and Ruresz, S. (1970) Experimental data on the interaction between rifampicin and tetracycline. In Progress in Antimicrobial and Ariza, J., Corredoira, J., Pallares, R., Viladrich, P.F., Rufl, G., Pujol, M. and Gudiol, F. (1995) Characteristics of and risk factors for relapse of brucellosis in humans. Clin Infect Dis., 20, 1241–1249.

    Google Scholar 

  • Ariza, J., Gudiol, F., Pallares, R., Rufl, G. and Fernandez Viladrich, P. (1985) Comparative trial of rifampicin-doxycycline versus tetracycline-streptomycin in the therapy of human brucellosis. Antimicrob Agents Chemother., 28, 548–551.

    PubMed  CAS  Google Scholar 

  • Ariza, J., Gudiol, F., Pallares, R., Rufi, G. and Fernandez-Viladrich, P. (1985a) Comparative trial of rifampicin-doxycycline versus tetracycline-streptomycin in the therapy of human brucellosis. Antimierob Agents Chemother., 28, 548–551.

    CAS  Google Scholar 

  • Ariza, J., Gudiol, F., Pallares, R., Rufi, G. and Fernandez-Viladrich, P. (1985b) Comparative trial of cotrimoxazole versus tetracy-cline-streptomycin in treating human brucellosis. J. Infect Dis., 152, 1358–1359.

    PubMed  CAS  Google Scholar 

  • Ariza, J., Gudiol, F., Pallares, R., Viladrich, P.F., Rufi, G., Corredoira, J. and Miravitlles, M.R. (1992) Treatment of human brucellosis with doxycycline plus rifampicin or doxycycline plus streptomycin. Ann Int Med., 117, 25–30.

    PubMed  CAS  Google Scholar 

  • Ariza, J., Gudiol, F., Rufi, G. and Priu, R. (1977) Tratamiento de la brucellosis aguda con trimetoprimsulfametaxazol. Med Clin (Bare), 69, 437–441.

    Google Scholar 

  • Bailey, T.C., Little, J.R., Littenberg, B., Reichley, R.M. and Dunagan, W.C. (1997) A meta-analysis of extended-interval dosing versus multiple daily dosing of aminoglycosides. Clin Infect Dis., 24, 786–795.

    PubMed  CAS  Google Scholar 

  • Baldwin, D. R., Wise, R., Andrew, J. M. et al. (1990) Azithromycin concentrations at the site of pulmonary infection. Eur. Respir. J., 3, 886–890.

    PubMed  CAS  Google Scholar 

  • Benjamin, B. and Annobil, S.H. (1992) Childhood brucellosis in southwestern Saudi Arabia: a 5-year experience. J Trop Pediatr (England), 38, 167–172.

    CAS  Google Scholar 

  • Benjamin, B. and Khan, M.R. (1994) Hip involvement in childhood brucellosis. J Bone Joint Surg Br., 76, 544–547.

    PubMed  CAS  Google Scholar 

  • Benjamin, B., Annobil, S.H. and Khan, M.R. (1992) Osteoarticular localizations of childhood brucellosis: a study of 57 cases in Saudi Arabia. J Pediatr Orthop (United States), 12, 801–805.

    CAS  Google Scholar 

  • Bertino Jr., J.S. and Rotschafer, J.C. (1997) Editorial response: Single daily dosing of aminoglycosides-A concept whose time has not yet come. Clin Infect Dis., 24, 802–803.

    Google Scholar 

  • Bertrand, A., Janbon, F., Jourdan, J. and Lepue, G. (1982) Immunotherapy of chronic non-focal brucellosis. Med. Malad. Infect., 12, 610–613.

    Google Scholar 

  • Bocker, R. and Estler, C.J. (1983) Quantitative assessment of a newly detected metabolite of doxycycline: in vitro formation and in vivo distribution of N-demethyldoxycycline in mice. Drug Exp Clin Res., 9, 813–819.

    Google Scholar 

  • Bosch, J., Linares, J., Lopez de Goichoechea, M.J., Cisnal, M.C. and Martin, R. (1986) In vitro activity of ciprofloxaxin, ceftriaxone and five other antimicrobial agents against 95 strains of Brucella melitensis. J. Antimierob. Chemother., 17, 459–461.

    CAS  Google Scholar 

  • Boura, P., Tsapas, G., Kountouras, J. and Zaharioudaki, E. (1995) Interferon-A 2a administration in chronic anergic brucellosis. Hepatogastroenterology, 42, 919–922.

    PubMed  CAS  Google Scholar 

  • Brealey, L.J., Stragis, A. and Storey, E. (1968) Tetracycline-induced tooth changes: Part I. Prevalence in pre-school children. Med. J. Aust., 2, 653–658.

    Google Scholar 

  • Bruce, D. (1889) Malta fever. Br. Med. J., i, 1101–1107.

    Google Scholar 

  • Brumfitt, W. and Hamilton Miller, J.M. (1994) Limitations of and indications for the use of cotrimoxazole. J Chemother., 6, 3–11.

    PubMed  CAS  Google Scholar 

  • Busby, S. R. M. and Hitchings, G. H. (1968) Trimethoprim, a sulphonamide potentiator. Br. J. Pharmacol. Chemother., 33, 72–90.

    Google Scholar 

  • Cisneros, J.M., Viciana, P., Colmenero, J., Pachon, J., Martinez, C. and Alarcon, A. (1990) Multicenter prospective study of treatment of Brucella melitensis. Antimierob Agents Chemother., 34, 881–883.

    CAS  Google Scholar 

  • Clerk, A. L. (1939) Urinary tract infection acompanying brucellosis. J. Urol., 42, 249–256.

    Google Scholar 

  • Cohlen, S.Q., Bevelander, G. and Tiamsic, T. (1963) Growth inhibition of prematures receiving tetracycline. Am. J. Dis. Child., 105, 65–73.

    Google Scholar 

  • Colmenero Castillo, J.D., Hernandez Marquez, S., Reguera Iglesias, J.M., Cabrera Franquelo, F., Rius Diaz, F. and Alonso, A. (1989) Comparative trial of doxycycline plus streptomycin versus doxycycline plus rifampicin for the therapy of human brucellosis. Chemotherapy, 35, 146–152.

    PubMed  CAS  Google Scholar 

  • Colmenero, J. D., Fernandez Gallardo, L. C., Agundez, J. A., Sedeno, J. and Benitez, J. (1994) Possible implications of doxycycline-rifampicin interaction for treatment of brucellosis. Antimierob Agents Chemother., 38, 2798–2802.

    CAS  Google Scholar 

  • Colmenero, J., Valdivieslo, P., Camps, T., Trujilloy, J. and Juarez, C. (1983) Brucellosis-a clinical and epidemiological study of 139 cases. Med. Clin. (Bare), 80, 748–751.

    Google Scholar 

  • Colmenero, J.D., Reguera, J.M., Cabrera, F.P., Cisneros, J.M., Orjuela, D.L. and Fernandez Crehuet, J. (1990) Serology, clinical manifestations and treatment of brucellosis in different age groups. Infection (Germany, West), 18, 152–156.

    CAS  Google Scholar 

  • Conte, G., Bacchiocchi, D and Jankovic, M. (1994) Brucellosis in childhood: therapeutic contribution. Minerva Pediatr., 46, 527–529.

    PubMed  CAS  Google Scholar 

  • Conti, R. and Parenti, F. (1983) Rifampicin therapy for brucellosis, flabobacterium meningitis and cutaneous leishmaniasis. Rev. Infect. Dis., 5, S600–S605.

    PubMed  Google Scholar 

  • Creixems, M. R., Buzon, L., Meseguer, M., Martinez, J. and Bouza, E. (1980) Rifampicin as a single agent in the treatment of acute brucellosis in humans. In Current Chemotherapy and Infectious Diseases, American Society of Microbiology, Washington, pp. 1064–1066.

    Google Scholar 

  • Culbertson, W. W., Huang, A. J., Mandelbaum, S. A. et al. (1993) Effective treatment of phylctenular keratoconjunctivitis with oral tetracycline. Ophthalmology, 100, 1358–1366.

    PubMed  CAS  Google Scholar 

  • Daikos, G. K., Papapolyzos, N., Marketos, N., Mochlas, S., Kastanakis, S. and Papasteriadis. E. (1973) Trimethoprim-sulfamethoxa-zole in brucellosis. J. Infect. Dis., 128, S731–S733.

    Google Scholar 

  • Dalton, M. J., Clarke, M. J., Holman, R. C. et al. (1995) National surveillance for Rocky Mountain spotted fever 1981–1992: Epidemiology summary and evaluation of risk factors for fatal outcome. Am J Trop Med Hyg, 52, 405–413.

    PubMed  CAS  Google Scholar 

  • De Gowin, E. L., Carter, J. R. and Borts, I. H. (1945) A case of infection with Brucella suis causing endocarditis and nephritis, death from rupture of mycotic aneurysm. Am. Heart. J., 30, 77–87.

    Google Scholar 

  • De Jong, R. N. (1936) Central nervous system involvement in undulant fever, with the report of a case and a survey of the literature. J. Nerv. Ment. Dis., 83, 430–432.

    Google Scholar 

  • De la Fuente, A. (1997) Infection of a pacemaker by Brucella melitensis. Tex Heart Inst J., 24, 129–130.

    PubMed  Google Scholar 

  • de Rautlin de la Roy, Y.M., Grignon, B., Grollier, G, Coindreau, M.F. and Becq-Giraudon, B. (1986) Rifampicin resistance in a strain of Brucella melitensis after treatment with doxycycline and rifampicin (letter). J Antimierob Chemother., 18, 648–649.

    Google Scholar 

  • De Rycke, J. (1980) Effect of rifampicin and tetracycline alone and in combination against Brucella suis. Ann. Microbiol. (Inst. Pasteur), 131, 277–287.

    Google Scholar 

  • Dees, C., Fountain, M. W., Taylor, J. R. and Schultz, R. D. (1985) Enhanced intraphagocytic killing of Brucella abortus in bovine mononuclear cells by liposome containing gentamicin. Vet. Immunol. Immunopathol., 8, 171–182.

    PubMed  CAS  Google Scholar 

  • Demers, P., Fraser, D., Goldbloom, R. S. et al. (1968) Effects of tetracycline on skeletal growth and dentition: a report by the Nutrition Committee of the Canadian Paediatric Society, Can. Med. Assoc. J., 99, 849–854.

    PubMed  CAS  Google Scholar 

  • Domingo, S. and Gamazo, C. (1996) Inadequate azithromycin activity against Brucella melitensis in mice with acute or chronic infections. J Chemother., 8, 55–58.

    PubMed  CAS  Google Scholar 

  • Domingo, S., Diaz, R. and Gamazo, C. (1995) Antibiotic treatment induces an increase of the specific antibody levels in Brucella melitensis infected mice. FEMS Immunol Med Microbiol., 12, 91–95.

    PubMed  CAS  Google Scholar 

  • Domingo, S., Gastearena, I., Vitas, A.I., Lopez Gone, I., Dios Vieitez, C., Diaz, R. and Gamazo, C. (1996). Comparative activity of azithromycin and doxycycline against Brucella spp. J Antimierob Chemother., 36, 647–656.

    Google Scholar 

  • Eisele, C. W. and McCullough, N. B. (1947) Combined streptomycin and sulfadiazine treatment in brucellosis. JAMA, 135, 1053–1055.

    CAS  Google Scholar 

  • Estevao, M.H., Barosa, L.M., Matos, L.M., Barroso, A.A. and da Mota, H.C. (1995) Neurobrucellosis in children. Eur J Pediatr., 154, 120–122.

    PubMed  CAS  Google Scholar 

  • Eyre, J. W. H. (1908) Melitensis septicaemia (Malta or Mediterranean fever). Lancet, i, 1747–1752.

    Google Scholar 

  • Farid, Z., Miale, A., Omar, S and Van Peenan, P. F. (1961) Antibiotic treatment of acute brucellosis caused by Brucella melitensis. J. Trop. Med. Hyg., 64, 157–163.

    PubMed  CAS  Google Scholar 

  • Farrell, I. D., Hinchcliffe, P. M. and Robertson, L. (1976) Sensitivity of Brucella spp. to tetracycline and its analogues. J. Clin. Pathol, 29, 1097–1100.

    PubMed  CAS  Google Scholar 

  • Farrell, I. D.. and Robertson, L.R. The treatment of brucellosis (leading article). J. Antimierob. Chemother., 6, 695–697.

    Google Scholar 

  • Farrell, W., Wilks, M. and Drasar, F.A. (1977) the action of trimethoprim and rifampicin in combination against Gram-negative rods resistant to gentamicin. J. Antimierob. Chemother., 3, 459–462.

    Google Scholar 

  • Feiz, J. M., Sabbaghian, H. and Sohrabi, F. (1973) A comparative study of therapeutic agents used for treatment of acute brucellosis. Br. J. Clin. Pract., 27, 410–413.

    PubMed  CAS  Google Scholar 

  • Forti, G. and Benincori, C. I. (1969) Letter to the Editor, Lancet, i, 782.

    Google Scholar 

  • Fountain, M. W., Dees, C. and Schultz, R. D. (1981) Enhanced intracellular killing of Staphylococcus aureus by canine monocytes treated with liposomes containing amakacin, gentamycin, kanamycin and tobramycin. Curr. Microbiol., 6, 373–376.

    CAS  Google Scholar 

  • Freeman, C.D., Nicolau, D.R, Belliveau, P.P. and Nightingale, C.H. (1997) Once-daily dosing of aminoglycosides: review and recommendations for clinical practice. J Antimierob Chemother., 39, 677–686.

    CAS  Google Scholar 

  • Garcia Rodriguez, J.A., Garcia Sanchez, J.E., Trujillano Martin, I., Garcia Sanchez, E., Garcia Garcia, M.I. and Fresnadillo, M.J. (1994) Activity of BAY y 3118, a novel 4-quinolone, against Brucella melitensis. J Chemother., 6, 102–106.

    PubMed  CAS  Google Scholar 

  • Garcia Rodriguez, J.A., Garcia Sanchez, J.E., Trujillano, I., Garcia Sanchez, E., Garcia Garcia M.I. and Fresnadillo, M.J. (1995) Susceptibilities of Brucella melitensis isolates to clinafloxacin and four other new fluoroquinolones. Antimierob Agents Chemother., 39, 1194–1195.

    CAS  Google Scholar 

  • George, C.R. P. and Evans, R. A. (1971) Tetracycline toxicity in renal failure. Med. J. Aust., 1, 1271–1273.

    PubMed  CAS  Google Scholar 

  • Giunchi, G., De Rosa, F. and Fabiani, F. (1971) Trimethoprim-sulfa-methoxazole combination in the treatment of acute human brucellosis. Chemotherapy, 16, 332–335.

    PubMed  CAS  Google Scholar 

  • Gobernado, M., Canton, E. And Santos, M. (1985) In vitro activity of ciprofloxacin and other 4-quinolones against Brucella melitensis. Proceedings of first International Ciprofloxacin Workshop, Current Clinical Practice Series 34, pp. 30–32.

    Google Scholar 

  • Gregoriadis, G. (1979) Liposomes. In Drug Carriers in Biology and Medicine (ed. G. Gregoriadis ), Academic Press, London, pp. 287–341.

    Google Scholar 

  • Grossman, E. R., Walchek, A., Freedman, H. and Flanagan, C. (1971) Tetracyclines and permanent teeth: the relation between dose and tooth colour. Pediatrics, 47, 567–570.

    PubMed  CAS  Google Scholar 

  • Groves, P. (1936) Sur quelques cas de melitococcie traités par le rubazol seul ou associé à des agents thérapeutiques spécifiques de l’affection. Lyon Med., 158, 615.

    Google Scholar 

  • Gutierres Altes, A., Diez Enciso, M., Pena garcia, P. and Campos-Buena, A. (1982) In vitro activity of N-formimodoyl thienamycin agailnst 98 clinical isolates of Brucella melitensis, compared with those of cefotoxin, rifampicin, tetracycline and cotrimoxazole. Antimierob. Agents Chemother., 21, 501–503.

    Google Scholar 

  • Guvenc, H., Kocabay, K., Okten, A. and Bektas, S. (1989) Brucellosis in a child complicated with multiple brain abscesses. Scand J Infect (Sweden), 21, 333–336.

    CAS  Google Scholar 

  • Gwynn, M. N. and Rolinson. G. N. (1980) Bactericidal action of amoxycillin alone and in combination with gentamycin and rifampicin against Brucella melitensis. J. Infect., 2, 61–65.

    PubMed  CAS  Google Scholar 

  • Haden R. L. and Kyger, E. R. (1946) Pulmonary manifestations of brucellosis. Cleve. Clin. Q., 13, 220–227.

    PubMed  CAS  Google Scholar 

  • Hall, W. H. and Manion, R. E. (1970) In vitro susceptibility of Brucella to various antibiotics. Appl. Microbiol, 20, 600–604.

    PubMed  CAS  Google Scholar 

  • Hall, W. H. and Spink, W.W. (1947) In vitro sensitivity of Brucella to styreptomycin treatment. Proc. Soc. Exp. Biol Med., 64, 403–406.

    PubMed  CAS  Google Scholar 

  • Harrell, W. E. and Barber, T. E. (1950) A new method for treatment of brucellosis. JAMA, 114, 519–524.

    Google Scholar 

  • Harrell, W.E. and Barber, T. E. (1952) Treatment of brucellosis with Aureomycin or Terramycin combined with dihydrostreptomycin. Postgrad. Med., 11, 476–478.

    Google Scholar 

  • Harvey, R. J. (1978) Antagonistic interaction of rifampicin and trimthoprim. J. Antimierob. Chemother., 4, 315–327.

    CAS  Google Scholar 

  • Hassan, A., Erian, M. M., Farid, S., Hathout, S. D. and Sorensen, K. (1971) Trimethoprim-sulphamethoxazole in acute brucellosis. Br. Med. J., iii, 159–160.

    Google Scholar 

  • Hatala, R., Dinh, T.T. and Cook, D.J. (1997) Single daily dosing of aminoglycosides in immunocompromised adults: a systematic review. Clin Infect Dis., 24, 810–815.

    PubMed  CAS  Google Scholar 

  • Havas, L. (1980) Problems and new developments in the treatment of acute and chronic brucellosis in man. Acta Trop., 37, 281–286.

    PubMed  CAS  Google Scholar 

  • Heilman, F. R. (1949) The effect of combined treatment with aureomycin and dihydrostreptomycin on brucella infection in mice. Proc. Staff Meet. Mayo Clin., 24, 133–137.

    CAS  Google Scholar 

  • Houang, E. T. and Greenwood, D. (1977) Aminoglycoside cross-resistance patterns of gentamicin-resistant bacteria. J. Clin. Pathol, 30, 738–744.

    PubMed  CAS  Google Scholar 

  • Isaac, A. G. (1938) Orchitis and epididymitis due to undulant fever. J. Urol, 40, 201–207.

    Google Scholar 

  • Juliano, R. L. and Stamp, D. (1978) Pharmocokinetics of liposome encapsulated antitumour drugs: studies with vinblastine, actinomycin D, cystosine arabinoside and daunomycin. Biochem. Pharmacol, 27, 21–27.

    PubMed  CAS  Google Scholar 

  • Kalowski, S., Nanra, R.S., Mathew, T.H. and Kincaid-Smith, P. (1973) Deterioration in renal function in association with cotrimoxazole therapy. Lancet, i, 394–397.

    Google Scholar 

  • Kandiah, D., Penny, W.J., Fraser, A.G. and Lewis, M.J. (1988) A possible drug interaction between rifampicin and enalapril. Eur J Clin Pharmacol, 35, 431–432.

    PubMed  CAS  Google Scholar 

  • Khan, M.Y., Dizon, M. and Kiel, F.W. (1989) Comparative in vitro activities of ofloxacin, difloxsacin, ciprofloxacin and other related selected antimicrobial agents against Brucella melitensis. Antimierob Agents Chemother., 33, 1409–1410.

    CAS  Google Scholar 

  • Khuri Bulos, N. and Shaker, K. (1991) Relapse of brucellosis following ofloxacin therapy (letter). J Infect., 22, 302–303.

    PubMed  CAS  Google Scholar 

  • Khuri Bulos, N.A., Daoud, A.H. and Azab, S.M. (1993) Treatment of childhood brucellosis: results of a prospective trial on 113 children. Pediatr Infect Dis J., 12, 377–381.

    PubMed  CAS  Google Scholar 

  • Killough, J. H., Magill, G. B. and Smith, R. C. (1951) Terramycin, chloramphenicol and Aureomycin in acute brucellosis. JAMA, 145, 553–556.

    CAS  Google Scholar 

  • Knight, V., Ruiz-Sanchez, F. and McDermott, W. Chloramphenicol in the treatment of the acute manifestations of brucellosis. Am J Med Sci, 1950; 219: 627–638.

    PubMed  CAS  Google Scholar 

  • Kondratieva, O. V., Stepanov, V. M. and Medredenko, N. P. (1979) Investigation of the effect of some peniicillins on brucella properties. Antibiotiki., 25, 454–458.

    Google Scholar 

  • Kono, K., Oisumi, K. and Oka, S. (1973) Mode of action of rifampicin against myobacteria. Am. Rev. Resp. Dis., 107, 1006–1012.

    Google Scholar 

  • Lai, S., Modwal, K. K., Fowle, A.S.E., Peach, B. and Popham, R. D. (1970) Acute brucellosis treated with trimethoprim and sulphamethoxazole. Br. Med. J., iii, 256–257.

    Google Scholar 

  • Landinez, R., Linares, J., Loza, E., Martinez Beltran, J., Martin, R. and Baquero, F. (1992) In vitro activity of azithromycin and tetracycline against 358 clinical isolates of Brucella melitensis. Eur J Clin Microbiol Infect Dis., 11, 265–267.

    PubMed  CAS  Google Scholar 

  • Lang, R. and Rubinstein, E. (1992) Quinolones for the treatment of brucellosis. J Antimierob Chemother., 29, 357–360.

    CAS  Google Scholar 

  • Lang, R., Dagan, R., Potasman, I., Einhorn, M. and Raz, R. (1992) Failure of ceftriaxone in the treatment of acute brucellosis. Clin Infect Dis., 14, 506–509.

    PubMed  CAS  Google Scholar 

  • Lang, R., Raz, R., Sacks, T. and Shapiro, M. (1990) Failure of pro-longed treatment with ciprofloxacin in acute infections due to Brucella melitensis. J Antimierob Chemother., 26, 841–846.

    CAS  Google Scholar 

  • Lang, R., Shasha, B., Ifrach, N., Tinman, S and Rubinstein, E. (1994) Therapeutic effects of roxithromycin and azithromycin in experimental murine brucellosis. Chemotherapy, 40, 252–255.

    PubMed  CAS  Google Scholar 

  • Leavell, H. R. and Amoss, H. L. (1931) Brucella infection: case report. Cultivation of brucella from the bile. Am. J. Med. Sci., 181, 96–102.

    Google Scholar 

  • Lepper, M. H., Wolfe, C. Z., Zimmerman, H. J., Caldwell, E. R., Spies, H. W. and Dowling, H. F. (1951) Effect of large doses of Aureomycin on human liver. Arch. Intern. Med., 88, 271.

    CAS  Google Scholar 

  • Little, P. J. and Bailey, R. R. (1970) Tetracyclines and renal failure. NZ Med. J., 72, 183–184.

    CAS  Google Scholar 

  • Llorens-Terol, J. and Busquets, R. M. (1980) Brucellosis treated with rifampicin. Arch. Dis. Child., 55, 486–488.

    PubMed  CAS  Google Scholar 

  • Lubani, M.M., Dudin, K.I., Sharda, D.C., Ndhar, D.S., Araj, G.F., Hafez, H.A. et al (1987). A multicenter therapeutic study of 1100 children with brucellosis. Pediatr Infect Dis J., 8, 75–78.

    Google Scholar 

  • Luzzi, G.A., Brindle, R., Sockett, P.N., Solera, J., Klenerman, P. and Warrell, D.A. (1993) Brucellosis: imported and laboratory-acquired cases, and an overview of treatment trials. Trans R Soc Trop Med Hyg., 87, 138–141.

    PubMed  CAS  Google Scholar 

  • Madkour, M. Monir (1996) Brucellosis. In: Weatherall, D. J., Ledingham, J. G. and Warrell., D. A. eds. Oxford Textbook of Medicine, 3rd Edition, Oxford: Oxford University Press, 619–623.

    Google Scholar 

  • Madkour, M. Monir, Rahman, A., Talukder, M. and Kudwah, A. (1985) Brucellosis in Saudi Arabia. Saudi Med J., 6, 324–332.

    Google Scholar 

  • Madkour. M. Monir. (1998) Brucellosis. In: Fauci, A. S., Braunwald, E., Isselbacher, K. J. et al. eds. Harrison’s Principles of Internal medicine, 14th Edition, New York: McGraw Hill, 969–971.

    Google Scholar 

  • Magill, G. B. and Killough, J. H. (1953) Oxytetracyclinestreptomycin therapy in brucellosis due to Brucella melitensis. Arch. Intern. Med., 91, 204–211.

    CAS  Google Scholar 

  • Magoffin, R. L. and Spink, W. W. (1951) The protection of intracellular brucella against streptomycin alone and in combination with other antibiotics. J. Lab. Clin. Med., 37, 924–930.

    PubMed  CAS  Google Scholar 

  • Mahon, W. A., Johnson, G. E., Endrenyi, L., Kelly, M. F. and Fenton, S.S.A. (1976) the elimination of tritiated doxycycline in normal subjects and in patients with severely impaired renal function. Scand. J. Infect. Dis. (Suppl.), 9, 24–31.

    Google Scholar 

  • Mahon, W. A., Wittenberg, J. V. And Tuffnel, P. G. (1970) Studies on the absorption and distribution of doxycycline in normal patients with severely impaired renal function. Can. Med. Assoc. J., 103, 1031–1034.

    PubMed  CAS  Google Scholar 

  • Mahoney, J. F. and Lloyd-Jones, D. (1975) Serum doxycycline levels after intravenous administration in haemodialysis patients. Med. J. Aust., 2, 673.

    Google Scholar 

  • Malik G.M. (1997) A clinical study of brucellosis in adults in the Asir Region of southern Saudi Arabia. Am J Trop Med Hyg., 56, 375–377.

    PubMed  CAS  Google Scholar 

  • Malik, G.M. (1998) Early clinical response to different therapeutic regimens for human brucellosis. Am J Trop Med Hyg., 58, 190–191.

    PubMed  CAS  Google Scholar 

  • Martin Moreno, S., Guinea Esquerado, L., Carrero Gonzalez, P., Visedo Orden, R., M., Garcia Carbajosa, S., Calvo del Olmo, T. and Reverte Cejudo, D. (1992) Brucellosis after treatment: the diagnosis of recurrences. Med Clin (Barc), 99, 13–16.

    CAS  Google Scholar 

  • Marzo Sola, M.E., Calderon Giron, C., Ayuso Blanco, T., Uson Martin, M., Marta Moreno, M.E. and Bestue Cardiel, M. (1995) Neurobrucellosis. A report of 13 cases. Neurologia, 10, 375–379.

    PubMed  CAS  Google Scholar 

  • McDevit, D. G. (1970) Ampicillin in the treatment of brucellosis — a controlled therapeutic trial. Br. J. Industr. Med., 27, 67–71.

    Google Scholar 

  • Merier, G., Laurencet, F. L., Rudhart, M. M., Chuit, A. and Fabre, J. (1969) Behaviour of doxycycline in renal insufficiency. Helv. Med. Acta., 35, 124–134.

    PubMed  CAS  Google Scholar 

  • Montejo, J.M., Alberola, I., Glez Zarate, P., Alvarez, A., Alonso, J., Canovas, A. and Aguirre, C. (1993) Open, randomized therapeutic trial of six antimicrobial regimens in the treatment of human brucellosis. Clin Infect Dis., 16, 671–676.

    PubMed  CAS  Google Scholar 

  • Mousa, A.M., Bahar, R.H., Araj, G.F., Koshy, T.S., Luhtaseb, S.A., Al Mudallal, D.S. and Marafie, A.A. (1990) Neurological localizations of brucella spondylitis. Acta Neurol Scand (Denmark), 81, 16–23.

    CAS  Google Scholar 

  • Palenque, E., Otero, J. R. and Noriega, A. R. (1986) In vitro susceptibility of Brucella melitensis to new cephalosporins crossing the blood-brain barrier. Antimicrob. Agents Chemother., 12, 182–183.

    Google Scholar 

  • Papapolizos, N., Tsiana-Papastergiou, A., Ioannou, O., Katsensis, I. And Kritikos, A. (1980) Amoxycillin in the treatment of acute brucellosis. J. Infect., 2, 161–163.

    PubMed  CAS  Google Scholar 

  • Pechere, J. C. (1993) Quinolones in intracellular infections. Drugs, 45, 29–36.

    PubMed  Google Scholar 

  • Pfischner, W. C. E., Ishak, K. G., Neptune, E. M. etal. 1957 ). Brucellosis in Egypt. A review of experience with 228 patients. Am. J. Med., 22, 915–929.

    PubMed  Google Scholar 

  • Phillipon, A. M., Plommet, M. G., Kazmierxzak, A., Marly, J. L. and Nevot, P. A. (1977) Rifampicin in the treatment of experimental brucellosis in mice and guinea pigs. J. Infect. Dis., 136, 482–488.

    Google Scholar 

  • Poston, M. A. and Smith, D. T. (1936) Successful treatment of brucella meningitis with immune human serum: isolation of the organisms by a modified culture method. N. Engl. J. Med., 215,369– 370.

    Google Scholar 

  • Poston, M. A. and Thomson, R. H. (1936) Meningitis due to Brucella in a child. Am. J. Dis. Child., 52, 904–906.

    Google Scholar 

  • Printziz, S., Raptopoulou, Gigi, M., Orphanou Koumerkeridou, H., Lagre, F and Goulis, G. (1994) Immunotherapy in chronic brucellosis. Effect of levamisole and interferon; mechanisms of action and clinical value. Immunopharmacol-Immunotoxicol., 16, 679–693.

    Google Scholar 

  • Pulaski, E. J. and Amspacher, W. H. (1947) Streptomycin therapy in brucellosis. Bull. US Army Med. Dept., 7, 221–225.

    CAS  Google Scholar 

  • Qadir, S. M. H., Halim, M. A. et al. (1995) Antibacterial activity of Azithromycin against B. melitensis. Chemotherapy, 41, 253–256.

    Google Scholar 

  • Qadri, S.M., Akhtar, M., Ueno, Y. and Al Sibai, M.B. (1989) Susceptibility of Brucella melitensis to fluoroquinolones. Drugs Exp Clin Res., 15, 483–485.

    PubMed  CAS  Google Scholar 

  • Quiroga, J. (1996) Surgical treatment of Brucella endocarditis. Cardiovasc Surg., 4, 227–230.

    PubMed  CAS  Google Scholar 

  • Reed, W.A., Elzer, P.H., Enright, F.M., Jaynes, J.M., Morrey, J.D. and White, K.L. (1997) Interleukin 2 promoter/enhancer controlled expression of a synthetic cecropinclass lytic peptide in transgenic mice and subsequent resistance to Brucella abortus. Transgenic Res., 6, 337–347.

    PubMed  CAS  Google Scholar 

  • Richardson, M. and Holt, J. N. (1962) Synergistic action of streptomycin with other antibiotics on intracellular Brucella abortus in vitro. J. Bacteriol., 84, 638–646.

    PubMed  CAS  Google Scholar 

  • Salter, A. J. (1982) Trimethoprim-sulfamethoxazole: an assessment of more than 12 years of use. Rev. Infect. Dis., 4, 196–236.

    PubMed  CAS  Google Scholar 

  • Sanchez-Tamayo, T., Colmenero, J.D., Martinez Cortes, F. and Moreiras, A. (19970 Failure of short-term antimicrobial therapy in childhood brucellosis. Pediatr Infect Dis., 16, 323–324.

    Google Scholar 

  • Sanders, W. E. (1931) Undulant fever meningitis (organism in spinal fluid). J. Iowa Med. Soc., 21, 510–511.

    Google Scholar 

  • Shir, Y. And Michel, J. (1984) Susceptibility of Brucella strains to antibiotics. Pathol. Biol., 32, 381–383.

    PubMed  CAS  Google Scholar 

  • Simpson, W. M. and Fraiser, E. (1929) Undulant fever. Report of sixty-three cases occurring in and about Dayton, Ohio. JAMA, 93, 1958–1963.

    Google Scholar 

  • Sippel, J. E., Michail, I. A., Girgis, N. I. and Youssef, H. H. (1974) Rifampicin concentration in cerebrospinal fluid of patients with tuberculous meningitis. Am. Rev. Resp. Dis., 21, 132–133.

    Google Scholar 

  • Smith, K. M. and Curtis, A. C. (1939) Brucellosis with endocarditis. Report of a case with failure of sulphanilamide therapy. Am. J. Med. Sci., 198, 342–348.

    Google Scholar 

  • Solera, J., Espinosa, A., Geijo, P., Martinez Alfaro, E., Saez, L., Sepulveda, M.A. and Ruiz Ribo, M.D. (1996) Treatment of human brucellosis with netilmicin and doxycycline. Clin Infect Dis., 22, 441–445.

    PubMed  CAS  Google Scholar 

  • Solera, J., Espinosa, A., Martinez Alfaro, e., Sanchez, L., Geijo, P., Navarro, E., Escribano, J. and Fernandez, J.A. (1997) Treatment of human brucellosis with doxycycline and gentamicin. Antimicrob Agents Chemother., 41, 80–84.

    PubMed  CAS  Google Scholar 

  • Solera, J., Martinez Alfaro, E. and Espinosa, A. (1997) Recognition and optimum treatment of brucellosis. Drugs, 53, 245–256.

    PubMed  CAS  Google Scholar 

  • Solera, J., Martinez Alfaro, E. and Saez L. (1994) Meta analysis of the efficacy of the combination of +rifampicin and doxycycline in the treatment of human brucellosis. Med Clin Bare., 102, 731–738.

    CAS  Google Scholar 

  • Solera, J., Martinez Alfaro, E., Espinosa, A., Castillejos, M.L., Geijo, P. and Rodriguez Zapata, M. (1998) Multivariate model for predicting relapse in human brucellosis. J Infect (England), 36, 85–92.

    CAS  Google Scholar 

  • Solera, J., Medrano, F., Rodriguez, M., Geijo, P. and Paulino, J. (1991) A comparative therapeutic and multicenter trial of rifampicin and doxycycline versus streptomycin and doxycycline in human brucellosis. Med Clin Bare., 96, 649–653.

    CAS  Google Scholar 

  • Solera, J., Rodriguez-Zapata, M., Geijo, P., Largo, J., Paulino, J. and Saez, L. (1995) Doxycycline-rifampicin versus doxycycline-streptomycin in treatment of human brucellosis due to Brucella melitensis. Antimicrob Agents Chemother., 39, 2061–2067.

    PubMed  CAS  Google Scholar 

  • Spink, W. W., and Bradley, G. M. (1960) Persistent parasitism in experimental brucellosis: attempts to eliminate brucellae with long-term tetracycline therapy. J. Lab. Clin. Med., 55, 535–547.

    PubMed  CAS  Google Scholar 

  • Spink, W. W., Braude, A. A., Castaneda, M. R. and Goytia, R. S. (1948) Aureomycin therapy in human brucellosis due to B. melitensis. JAMA, 138, 1145–1148.

    CAS  Google Scholar 

  • Spink, W. W., Hall, W. H., Shaffer, J. and Braude, A. I. (1949) Treatment of brucellosis with streptomycin and a sulfonamide drug. JAMA, 139, 352–356.

    CAS  Google Scholar 

  • Steigbigel, N. H., Reed, C. W. and Finland, M. (1968) Absorption and excretion of five tetracycline analogues in normal young men. Am. J. Med. Sci., 255, 296–312.

    PubMed  CAS  Google Scholar 

  • Stenbaek, O. Mhyre, E. and Berdal, B. P. (1973) The effect of doxycycline on renal function with advanced renal insufficiency. Scand. J. Infect. Dis., 5, 199–202.

    PubMed  CAS  Google Scholar 

  • Stewart, D. J. (1964) The effects of tetracyclines upon the dentition. Br. J. Dermatol, 76, 374–378.

    PubMed  CAS  Google Scholar 

  • Stuart, E A. (1982) Comparison of rifampicin and tetracycline-based regimens in the treatment of experimental brucellosis. J. Infect., 5, 27–34.

    CAS  Google Scholar 

  • Tasker, P. R. W., MacGregor, G. A., de Wardener, H. E. et al (1975) Use of cotrimoxazole in chronic renal failure. Lancet, i, 1216–1218.

    Google Scholar 

  • Toaff, R. and Ravid, R. (1966) Tetracyclines and the teeth. Lancet, i, 282–282.

    Google Scholar 

  • Vitas, A.I., Diaz, R. and Gamazo, C. (1995) Protective effect of Brucella outer membrane complex-bearing liposomes against experimental murine brucellosis. FEMS Microbiol Lett., 130, 231–236.

    PubMed  CAS  Google Scholar 

  • Vitas, A.I., Diaz, R. and Gamazo, C. (1997) Protective effect of liposomal gentamicin against systemic acute murine brucellosis. Chemotherapy, 43, 204–210.

    PubMed  CAS  Google Scholar 

  • Vitas, A.R., Diaz, R. and Gamazo, C. (1996) Effect of composition and method of preparation of liposomes on their stability and interaction with murine monocytes infected with Brucella abortus. Antimicrob Agents Chemother., 40; 146–151.

    PubMed  CAS  Google Scholar 

  • Wainwright, C. (1937) Melitensis infection. Treatment with neoarsphenamine. South. Med. J., 30, 600.

    Google Scholar 

  • Whelton, A., Schach von Wittenau, M., Twomey, T. M., Walker, W. G. and Bianchine, J. R. (1974) Doxycycline pharmacokinetics in the absence of renal function. Kidney Int., 5, 364–371.

    Google Scholar 

  • Zhan, Y.F., Stanley, E.R. and Cheers, C. (1991) Prophylaxis or treatment of experimental brucellosis with interleukin-1. Infect Immun (United States), 59, 1790–1794.

    CAS  Google Scholar 

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Madkour, M.M. (2001). Treatment. In: Madkour’s Brucellosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59533-2_24

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