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Using Transgenic Mice to Probe the Role of Specific Genes in Behavior

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Contemporary Psychiatry

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Abstract

This chapter will describe transgenic techniques that permit experimental manipulation of gene expression in the mouse. These techniques create specific and permanent changes to the germline of experimental mice, and these strategies have been fruitfully applied to the study of oncology, immunology, development, and more recently neurobiology and behavior. Specifically, in the area of neurobiology, modification of gene expression in the mouse has permitted direct assessment of the role of specific genes in the development of neural physiologic processes and in regulating behavior. Since this technique and its application to mouse behavior may seem far removed from the subject of human psychiatric disorders, we will first begin with a review of some basic concepts in molecular biology, followed by a brief introduction that will place the transgenic mouse strategy in the context of other genetic approaches to studying behavior.

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Authors
  1. J. A. Gingrich
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  2. R. Hen
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Editors and Affiliations

  1. Zentralinstitut für Seelische Gesundheit, P.O. Box 12 21 20, 68072, Mannheim, Germany

    Fritz Henn

  2. Belle-Idée, Bâtiment Salève, Hôpitaux Universitaires de Genève, 2, chemin du Petit-Bel-Air, 1225, Chêne-Bourg/Genève, Switzerland

    Norman Sartorius

  3. Psychiatrische Klinik, Freie Universität Berlin, Eschenallee 3, 14050, Berlin, Germany

    Hanfried Helmchen

  4. Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Germany

    Hans Lauter

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Gingrich, J.A., Hen, R. (2001). Using Transgenic Mice to Probe the Role of Specific Genes in Behavior. In: Henn, F., Sartorius, N., Helmchen, H., Lauter, H. (eds) Contemporary Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59519-6_5

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  • DOI: https://doi.org/10.1007/978-3-642-59519-6_5

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