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Cell and Tissue Transplantation in the Rodent CNS

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Modern Techniques in Neuroscience Research

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Abstract

Transplantation of cells/tissue to the central nervous system (CNS) is a widely used experimental tool for studies of developmental and regenerative processes (for reviews, see in Dunnett and Björklund (eds) (1994), and Gaiano and Fishell (1998)). Transplantation is also of major interest with regard to neurodegenerative diseases as well as to several other CNS disorders, since experiments in related animal models have shown that grafts can ameliorate lesion-induced deficits. Depending on the characteristics of the disease model and of the implanted cells/tissue, such graft-derived functional effects have been shown to be mediated through different mechanisms, such as partial reconstruction of damaged circuitries, diffuse release of substances, trophic support and stimulation of regenerative processes (Dunnett and Björklund 1994). Indeed, transplantation is today also applied in clinical trials in patients with, for example, Parkinson’s disease or Huntington’s chorea (Lindvall 1994, Kopyov et al 1998, and in Freeman and Widner (eds) 1998).

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Authors
  1. Klas Wictorin
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  2. Martin Olsson
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  3. Kenneth Campbell
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  4. Rosemary Fricker
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Editors and Affiliations

  1. Center of Musculoskeletat Research, National Institute for Working Life, Petrus Laestadius väg, 90713, Umeå, Sweden

    Uwe Windhorst  & Håkan Johansson  & 

  2. Department of Clinical Neurosciences and Department of Physiology and Biophysics Faculty of Medicine, The University of Calgary, 333 Hospital Drive N.W., Calgary, Alberta, T2N 4N1, Canada

    Uwe Windhorst

  3. Zentrum Physiologie und Pathophysiologie, Universität Göttingen, Humboldtallee 23, 37073, Göttingen, Germany

    Uwe Windhorst

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Wictorin, K., Olsson, M., Campbell, K., Fricker, R. (1999). Cell and Tissue Transplantation in the Rodent CNS. In: Windhorst, U., Johansson, H. (eds) Modern Techniques in Neuroscience Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58552-4_14

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  • DOI: https://doi.org/10.1007/978-3-642-58552-4_14

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