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The Role of Nitrates in Congestive Heart Failure

  • Conference paper
Heart Failure Mechanisms and Management

Abstract

The use of intravenous nitroglycerin (NTG) and long-acting nitrates in acute and chronic congestive heart failure (CHF) has been popular since the introduction of vasodilator therapy for CHF in the early 1970s. Although the angiotensin-converting enzyme (ACE) inhibitors have become extremely popular as “unloading” agents in CHF, current evidence suggests that nitrates may be comparably effective to these agents. It is of interest that both classes of drugs exert their effects on the venous and arterial sides of the circulation in heart faiure, with a subsequent reduction in preload and afterload of the heart. This discussion relates only to the patient with CHF and depressed left ventricular contractile or systolic function (e.g., ejection fraction less than 35%–40%).

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References

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Authors
  1. J. Abrams
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Editor information

Editors and Affiliations

  1. Department of Cardiology, Lady Davis Carmel Hospital, 34362, Haifa, Israel

    Basil S. Lewis MD (Director) (Director)

  2. University of California, Los Angeles, USA

    Asher Kimchi MD (Assistant Clinical Professor of Medicine, Attending Physician) (Assistant Clinical Professor of Medicine, Attending Physician)

  3. Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA

    Asher Kimchi MD (Assistant Clinical Professor of Medicine, Attending Physician) (Assistant Clinical Professor of Medicine, Attending Physician)

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© 1991 Springer-Verlag Berlin Heidelberg

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Abrams, J. (1991). The Role of Nitrates in Congestive Heart Failure. In: Lewis, B.S., Kimchi, A. (eds) Heart Failure Mechanisms and Management. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58231-8_26

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  • DOI: https://doi.org/10.1007/978-3-642-58231-8_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63509-0

  • Online ISBN: 978-3-642-58231-8

  • eBook Packages: Springer Book Archive

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