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The Role of Macrophages in Atherogenesis — Platelet-Monocyte Interactions

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Platelets and Atherosclerosis

Abstract

Monocytes/macrophages regulate specific and nonspecific immune reactions in response to infections and tumors. The secretory products of macrophages are important mediators for inflammation; in addition, macrophages influence the growth of cells and tissues by releasing specific growth factors.

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References

  1. Brown MS, Goldstein JL (1983) Lipoprotein metabolism in the macrophage: implication for cholesterol deposition in atherosclerosis. Ann U Rev Biochem 52:223–261

    Article  CAS  Google Scholar 

  2. Chandler AB, Hand RA (1961) Phagocytized platelets: a source of lipids in human thrombi and atherosclerotic plaques. Science 134:946

    Article  PubMed  CAS  Google Scholar 

  3. Faggiotto A, Ross R, Harker L (1984) Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation. Arteriosclerosis 4:323–340

    Article  PubMed  CAS  Google Scholar 

  4. Fogelman AM, Shechter I, Seager J, Hokom M, Child JS, Edwards PA (1980) Malondialdehyd alteration of low density lipoprotein leads to cholesteryl ester accumulation in human monocyte-macrophage. Proc Natl Acad Sci USA 77:269–271

    Article  Google Scholar 

  5. Fowler SD, Mayer EP, Greenspan P (1986) Foam cells and atherogenesis. Ann NY Acad Sci IV:79–90

    Google Scholar 

  6. Gerrity RG (1981) Role of the monocyte in ahterogenesis. 1. Transition of bloodborine monocytes into foam cells in fatty lesions. Am J Pathol 103:181–190

    PubMed  CAS  Google Scholar 

  7. Goldstein JL, Ho YK, Basu SK, Brown MS (1979) Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci USA 76:333–337

    Article  PubMed  CAS  Google Scholar 

  8. Goldstein JL, HO YK, Brown MS, Innerarity TL, Mahley RW (1980) Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine-very low density lipoproteins. J Biol Chem 255:1839–1848

    PubMed  CAS  Google Scholar 

  9. Henriksen T, Mahoney EM, Steinberg D (1981) Enhanced macrophage degradation of low-density lipoprotein previously incubated with cultured endothelial cells: recognition by receptor for acetylated low density lipoprotein. Proc Natl Acad Sci USA 78:6499–6503

    Article  PubMed  CAS  Google Scholar 

  10. Ho YK, Brown MS, Goldstein JL (1980) Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high-density-lipoprotein and other agents. J Lipid Res 21:391–398

    PubMed  CAS  Google Scholar 

  11. Karlin JB, Johnson WJ, Benedict CR, Chacko GK, Phillips MC, Rothblat GH (1987) Cholesterol flux between cells and high density lipoprotein to the cell surface. J Biol Chem 262:12557–12564

    PubMed  CAS  Google Scholar 

  12. Lindqvist P, Ostlund-Lindqvist A, Witztum JL, Steinberg D, Little JA (1983) The role of lipoprotein lipase in the metabolism of triglyceride-rich lipoproteins by macrophages. J Biol Chem 258:9086–9092

    PubMed  CAS  Google Scholar 

  13. Mainardi CL, Seyer JM, Kaqng AH (1980) Type-specific collagenases A type V collagen-degrading enzyme from macrophages. Biochem Biophys Res Commun 97:1108–1115

    Article  PubMed  CAS  Google Scholar 

  14. Nathan CF (1987) Secretory products of macrophages. J Clin Invest 79:319–326

    Article  PubMed  CAS  Google Scholar 

  15. Osteryud B, Lindahl U, Seljelid R (1980) Macrophages produce coagulant factors. FEBS Lett 120:41–43

    Article  Google Scholar 

  16. Palinski W, Rosenfeld ME, Ylä-Herttuala S et al. (1989) Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci USA 86:1372–1376

    Article  PubMed  CAS  Google Scholar 

  17. Rivers RPA, Hathaway WE, Weston WL (1975) The endotoxin-induced coagulant activity of human monocytes. Br J Haematol 30:311–316

    Article  PubMed  CAS  Google Scholar 

  18. Sevitt S (1986) Platelets and foam cells in the evolution of atherosclerosis, histological and immunohistological studies of human lesions. Atherosclerosis 61:107–115

    Article  PubMed  CAS  Google Scholar 

  19. Shimokado K, Raines EW, Madtes DK, Barett TB, Benditt EP, Ross R (1985) A significant part of macrophage derived growth factor consists of at least two forms of PDGF. Cell 43:277

    Article  PubMed  CAS  Google Scholar 

  20. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL (1989) Beyond cholesterol; modifications of low density lipoprotein that increases its atherogenicity. N Engl J Med 320:915–924

    Article  PubMed  CAS  Google Scholar 

  21. Steinbrecher UP, Parthasarathy S, Leake DS, Witztum JL, Steinberg D (1984) Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci USA 81:3883–3887

    Article  PubMed  CAS  Google Scholar 

  22. Takemura R, Werb Z (1984) Secretory products of macrophages and their physiological functions. Am J Physiol 246:C1–C9

    PubMed  CAS  Google Scholar 

  23. von Hodenberg E, Khoo JC, Vance J, Witztum JL, Jensen D (1984) Mobilization of stored triglycerides from macrophages as free fatty acids. Arteriosclerosis 4:630–635

    Article  Google Scholar 

  24. Werb Z, Gordon S (1975) Elastase secretion by stimulated macrophages: characterization and regulation. J Exp Med 142:361–377

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. E. von Hodenberg
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  2. S. Heinen
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  3. M. Hauptmann
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  4. J. Kreuzer
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  5. H. Henningsen
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  6. W. Kübler
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Editor information

Editors and Affiliations

  1. Klinik für Neurologie der Medizinischen Universität zu Lübeck, Ratzeburger Allee 160, W-2400, Lübeck 1, Germany

    Christof Kessler

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© 1990 Springer-Verlag Berlin Heidelberg

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von Hodenberg, E., Heinen, S., Hauptmann, M., Kreuzer, J., Henningsen, H., Kübler, W. (1990). The Role of Macrophages in Atherogenesis — Platelet-Monocyte Interactions. In: Kessler, C. (eds) Platelets and Atherosclerosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58225-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-58225-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53006-0

  • Online ISBN: 978-3-642-58225-7

  • eBook Packages: Springer Book Archive

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