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Treatment of Brain Metastasis

  • Chapter
Combined Modality Therapy of Central Nervous System Tumors

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Metastatic brain tumors present major management problem in patients with cancer. The incidence of brain metastases is increasing with the increase in our ability to control with surgery or radiotherapy, disease at the primary site, and with chemotherapy, systemic extracranial disease. In the 1970s, approximately 18% of patients dying of cancer were found at autopsy to have brain metastases (Posner 1977). In a national survey of US hospitals on patients admitted during 1973 to 1974, nearly equal numbers of patients were diagnosed as having primary and metastatic brain tumors (Walker et al. 1985). Several years later, it has been estimated that 30% of patients with metastatic tumors develop brain metastases (Cairncross and Posner 1983). The incidence of primary malignant brain tumors is increasing, however the incidence of brain metastases is increasing at a higher rate. At the present time, the ratio of metastatic to primary brain tumor is nearly 6:1 (Laws and Thapar 1993). It has been estimated that from 100,000 to 170,000 new patients with metastatic disease are diagnosed per year in the United States (Patchell et al. 1990; Posner 1992; Laws and Thapar 1993).

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Author information

Authors and Affiliations

  1. Professor and Chairman, Department of Radiation Oncology, University of Southern California School of Medicine, 1441 Eastlake Avenue G34, Los Angeles, CA, 90033, USA

    Zbigniew Petrovich

  2. PhD Assistant Professor, Department of Radiation Oncology-Physics, University of Southern California School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA, 90033, USA

    Cheng Yu

  3. Professor, Neurological Surgery, University of Southern California School of Medicine, LAC+USC Medical Center, 1200 North State Street, Room 5046, Los Angeles, CA, 90033, USA

    Michael L.J. Apuzzo

Authors
  1. Zbigniew Petrovich
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  2. Cheng Yu
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  3. Michael L.J. Apuzzo
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, University of Southern California, Keck School of Medicine 1441 Eastlake Avenue, Room G356, Los Angeles, CA, 90033-0804, USA

    Zbigniew Petrovich MD, FACR (Professor and Chairman) (Professor and Chairman)

  2. Department of Radiation Oncology, Hahnemann University Hospital, Broad & Vine Sts., Mail Stop 200, Philadelphia, PA, 19102, USA

    Luther W. Brady MD (Hylda Cohn/ American Cancer Society Professor of Clinical Oncology and Professor) (Hylda Cohn/ American Cancer Society Professor of Clinical Oncology and Professor)

  3. Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA

    Michael L. J. Apuzzo MD (Edwin M. Todd/Trent H. Wells, Jr. Professor of Neurological Surgery and Professor of Radiation Oncology) (Edwin M. Todd/Trent H. Wells, Jr. Professor of Neurological Surgery and Professor of Radiation Oncology)

  4. Department of Radiotherapy, Eberhard-Karls-Universität, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany

    Michael Bamberg MD

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© 2003 Springer-Verlag Berlin Heidelberg

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Petrovich, Z., Yu, C., Apuzzo, M.L. (2003). Treatment of Brain Metastasis. In: Petrovich, Z., Brady, L.W., Apuzzo, M.L.J., Bamberg, M. (eds) Combined Modality Therapy of Central Nervous System Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56411-6_21

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  • DOI: https://doi.org/10.1007/978-3-642-56411-6_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-00627-5

  • Online ISBN: 978-3-642-56411-6

  • eBook Packages: Springer Book Archive

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