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Molecular Vascular Embryology

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Pan Vascular Medicine

Abstract

The establishment of an intact, functional cardiovascular system is a prerequisite for embryonic development in vertebrates. A diagram showing the location of the major blood vessels in the embryonic cardiovascular system is presented in Fig. i. The importance of this system for delivering oxygen and nutrients to developing tissues is underscored by the early embryonic lethality of embryos deficient in essential cardiovascular genes. Despite a spatiotemporal correlation between the formation of the cardiac and vascular structures, these two systems undergo autonomous developmental programs. In fact, an intact vascular system will form perfectly well in the absence of a beating heart [1, 2]. Over the last 100 years, vascular development has been extensively studied by classical embryologists who described the formation of the first blood vessels. However, the absence of early vascular markers, especially markers for vascular endothelial precursor cells (angioblasts), greatly impeded studies aimed at understanding the initial events underlying vascular development.

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  1. Steven A. Vokes
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  2. Paul A. Krieg
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  1. Herz-Zentrum Coswig, Klinik für Kardiologie und Angiologie, Lerchenfeld 1, 06869, Coswig (Anhalt), Germany

    Peter Lanzer MD

  2. The Cleveland Clinic Foundation, One Clinic Center, 9500 Euclid Avenue, Cleveland, 44195, OH, USA

    Eric J. Topol MD

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Vokes, S.A., Krieg, P.A. (2002). Molecular Vascular Embryology. In: Lanzer, P., Topol, E.J. (eds) Pan Vascular Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56225-9_2

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