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Contribution of LCMV Transgenic Models to Understanding T Lymphocyte Development, Activation, Tolerance, and Autoimmunity

  • Chapter
Arenaviruses II

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 263))

Abstract

T cells play a central role in the elimination of both intracellular and extracellular pathogens. Expression of the αβ T cell receptor (TCR) heterodimer enables T cells to specifically recognize peptides presented by major histocompatibility complex (MHC) molecules and generate an immune response to those peptides. CD4+ helper T cells are restricted to MHC class II molecules, and produce cytokines to augment T and B cell responses. CD8+ T cells are restricted to MHC class I molecules, and are generally cytotoxic T lymphocytes (CTLs) whose effector function involves the lysis of infected cells. Broad issues in T cell biology include how mature T cells develop from bone marrow-derived precursors and how T cell activation is regulated. These questions and others have been addressed in many models, including murine TCR transgenic systems, in which the transgenic expression of TCR chains provides a clonal population of antigen-specific T cells that can be readily monitored.

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Authors and Affiliations

  1. Department of Immunology, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9

    L. T. Nguyen & P. S. Ohashi

  2. Cytos Ag, Wagistr. 21, 8952, Zurich-Schlieren, Switzerland

    M. F. Bachmann

  3. Department of Medical Biophysics and Immunology, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9

    P. S. Ohashi

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  1. L. T. Nguyen
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  2. M. F. Bachmann
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  3. P. S. Ohashi
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  1. Division of Virology Department of Neuropharmacology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone

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Nguyen, L.T., Bachmann, M.F., Ohashi, P.S. (2002). Contribution of LCMV Transgenic Models to Understanding T Lymphocyte Development, Activation, Tolerance, and Autoimmunity. In: Oldstone, M.B.A. (eds) Arenaviruses II. Current Topics in Microbiology and Immunology, vol 263. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56055-2_7

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