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Immunocytotherapy

  • Chapter
Arenaviruses II

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 263))

Abstract

Ever since the pioneering studies by Mogens Volkert and colleagues (Volkert et al. 1962–1967), lymphocytic choriomeningitis virus (LCMV), the prototypic member of the arenaviridae family, has become an important tool to evaluate the feasibility and efficacy of therapeutic immune cell grafting. Subsequent mechanistic and quantitative studies (Oldstone et al. 1986; Jamieson et al. 1987; Jamieson and Ahmed 1988; Tishon et al. 1995; Planz et al. 1997; Berger et al. 2000) have established the LCMV system as a primary immunocytotherapeutic model that continues to generate important insights for clinical applications in many human diseases. The remarkable flexibility of the LCMV system has also allowed for the exploration of different experimental strategies generating a complex of answers that appears appropriate to the multifaceted and intricate nature of diseases whose prevention or treatment may be improved by the adoptive transfer of immunologically active cells.

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Authors and Affiliations

  1. Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA

    D. Homann

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  1. D. Homann
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  1. Division of Virology Department of Neuropharmacology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone

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© 2002 Springer-Verlag Berlin Heidelberg

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Homann, D. (2002). Immunocytotherapy. In: Oldstone, M.B.A. (eds) Arenaviruses II. Current Topics in Microbiology and Immunology, vol 263. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56055-2_4

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  • DOI: https://doi.org/10.1007/978-3-642-56055-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62724-8

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