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Ursachen und Mechanismen der Leberschädigung

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Klinische Hepatologie

Zusammenfassung

Struktur und Funktion eines Organs sind untrennbar miteinander verbunden. Als zentrales Stoffwechselorgan des Menschen steht die Leber in ständiger Auseinandersetzung mit exogenen und endogenen Noxen. Zu den wichtigsten Ursachen der Leberschädigung zählen:

  • Ernährungs- und metabolische-hormonelle Störungen,

  • Medikamente und Toxine,

  • Erreger,

  • Endotoxine,

  • immunologische Störungen, z. B. primäre Autoimmunerkrankungen oder sekundäre Immunreaktionen bei viralen Infekten, medikamentösen und toxischen Schäden,

  • genetische Störungen, z. B. Speicherkrankheiten (Bilirubin, Glykogen, Eisen, Kupfer), zystische Fibrose, α1-Antitrypsinmangel,

  • Kreislaufstörungen, z. B. Ischämie, Reperfusion,

  • cholestatische Erkrankungen,

  • metallinduzierte Schäden, z. B. Eisen, Kupfer,

  • physikalische Schäden, z. B. mechanisches Trauma, ionisierende Strahlen.

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Authors and Affiliations

  1. Medizinische Klinik II, Klinikum Offenbach, Akademisches Lehrkrankenhaus der Johann Wolfgang Goethe-Universität, Starkenburgring 66, 63069, Offenbach, Deutschland

    Professor Dr. med. Henryk Dancygier

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  1. Professor Dr. med. Henryk Dancygier
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© 2003 Springer-Verlag Berlin Heidelberg

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Dancygier, H. (2003). Ursachen und Mechanismen der Leberschädigung. In: Klinische Hepatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55902-0_6

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  • DOI: https://doi.org/10.1007/978-3-642-55902-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-67559-4

  • Online ISBN: 978-3-642-55902-0

  • eBook Packages: Springer Book Archive

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