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Filaggrin-2

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Filaggrin

Abstract

Filaggrin-2 is, besides trichohyalin-like 1, trichohyalin, repetin, hornerin, pro-filaggrin, and cornulin, the seventh known member of the S100 fused-type protein family. The filaggrin-2 gene maps into the epidermal differentiation complex, which is located on human chromosome 1q21.3 between pro-filaggrin and cornulin. Filaggrin-2 mRNA and protein are mainly found in keratinizing epithelia, particularly in skin. Its expression pattern is restricted to the upper stratum granulosum and stratum corneum, similar to that of filaggrin, and is also dependent on the differentiation state of the keratinocytes. Structurally filaggrin-2 and filaggrin are closely related, as are all the other S100 fused-type protein members. They share a common genomic structure with three exons, of which the first is noncoding, the second carries the coding sequence for the first 47 amino acids, and the third comprises the remaining coding sequence. On the protein level, all S100 fused-type proteins possess an N-terminal (potential) Ca2+-binding S100/EF hand domain and multiple repeating units that differ from protein to protein. Filaggrin-2 has two kinds of repeats, one resembling partially repeats of hornerin and the other resembling in part the repeats of filaggrin. The role of filaggrin-2 in health and diseases is poorly understood and scarcely analyzed; current findings are summarized and will be further discussed in this chapter.

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Acknowledgment

This work was supported by grants from the Deutsche Forschungsgemeinschaft to J.-M. Schröder (Schr 305⁄6–1).

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Authors and Affiliations

  1. Department of Dermatology, University Hospital of Schleswig-Holstein, Schittenhelmstr. 7, Kiel, Schleswig-Holstein, 24105, Germany

    Jens-Michael Schröder PhD & Britta Hansmann PhD

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  1. Jens-Michael Schröder PhD
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  2. Britta Hansmann PhD
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Correspondence to Jens-Michael Schröder PhD .

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Editors and Affiliations

  1. Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

    Jacob P. Thyssen

  2. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Schröder, JM., Hansmann, B. (2014). Filaggrin-2. In: Thyssen, J., Maibach, H. (eds) Filaggrin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54379-1_6

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