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Filaggrin and the Oral Mucosa

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Filaggrin

Abstract

The stratified squamous epithelium of the oral mucosa is characterized by significant regional variations mainly with regard to differences in the degree of keratinization. The oral mucosa is also divided into lining, masticatory, and specialized types reflecting the functions in different areas. The permeability barrier in the oral mucosa is mainly a result of membrane-coating granules composed of various lipids that differs between nonkeratinized and keratinized regions of the oral mucosa. Another feature of the environment of the oral cavity is saliva, which contains mucins that lubricate and protect the oral mucosa. Filaggrin is believed to function as a matrix protein supporting the aggregation of keratin filaments, and it has been demonstrated in especially keratinized oral mucosa like the palate. Filaggrin and its metabolites may contribute to difference in the functions and properties of the oral epithelia. Likewise, filaggrin gene (FLG) mutations and altered distribution of filaggrin/profilaggrin in oral mucosa may play a role in disorders affecting the oral epithelia, including oral contact allergy.

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Authors and Affiliations

  1. Section of Oral Medicine, Clinical Oral Physiology, Oral Pathology and Anatomy, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Norre Alle 20, Copenhagen N, 2200, Denmark

    Anne Marie Lynge Pedersen PhD, DDS

  2. Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Norre Alle 20, Copenhagen N, 2200, Denmark

    Jesper Reibel PhD

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  1. Anne Marie Lynge Pedersen PhD, DDS
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  2. Jesper Reibel PhD
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Correspondence to Anne Marie Lynge Pedersen PhD, DDS .

Editor information

Editors and Affiliations

  1. Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

    Jacob P. Thyssen

  2. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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© 2014 Springer-Verlag Berlin Heidelberg

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Pedersen, A.M.L., Reibel, J. (2014). Filaggrin and the Oral Mucosa. In: Thyssen, J., Maibach, H. (eds) Filaggrin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54379-1_35

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  • DOI: https://doi.org/10.1007/978-3-642-54379-1_35

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54378-4

  • Online ISBN: 978-3-642-54379-1

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