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TRPM4

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Mammalian Transient Receptor Potential (TRP) Cation Channels

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 222))

Abstract

TRPM4 is a Ca2+-activated nonselective cation channel. The channel is activated by an increase of intracellular Ca2+ and is regulated by several factors including temperature and Pi(4,5)P2. TRPM4 allows Na+ entry into the cell upon activation, but is completely impermeable to Ca2+. Unlike TRPM5, its closest relative in the transient receptor potential family, TRPM4 proteins are widely expressed in the body. Currents with properties that are reminiscent of TRPM4 have been described in a variety of tissues since the advent of the patch clamp technology, but their physiological role is only beginning to be clarified with the increasing characterization of knockout mouse models for TRPM4. Furthermore, mutations in the TRPM4 gene have been associated with cardiac conduction disorders in human patients. This review aims to overview the currently available data on the functional properties of TRPM4 and the current understanding of its physiological role in healthy and diseased tissue.

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Acknowledgments

The author wishes to thank all members of the Laboratory of Ion Channel Research, and especially Prof. Emeritus Bernd Nilius, for stimulating discussions. This work is supported by the FWO Vlaanderen, the Bijzonder Onderzoeksfonds from the KU Leuven, and the Interuniversity Attraction Poles program from the federal Belgian government.

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Authors and Affiliations

  1. Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, bus 802, 3000, Leuven, Belgium

    Ilka Mathar, Griet Jacobs, Miklos Kecskes, Aurelie Menigoz, Koenraad Philippaert & Rudi Vennekens

  2. Pharmakologisches Institut, Im Neuenheimer Feld 366, 69120, Heidelberg, Germany

    Ilka Mathar

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  1. Ilka Mathar
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  2. Griet Jacobs
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  3. Miklos Kecskes
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  4. Aurelie Menigoz
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  5. Koenraad Philippaert
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  6. Rudi Vennekens
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Correspondence to Rudi Vennekens .

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  1. Laboratory Ion Channel Research Campus Gasthuisberg, KU Leuven Department Cell Mol Medicin, Leuven, Belgium

    Bernd Nilius

  2. Institut für Experimentelle u. Klinische, Pharmakologie und Toxikologie, Universität des Saarlandes, Homburg, Saarland, Germany

    Veit Flockerzi

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Mathar, I., Jacobs, G., Kecskes, M., Menigoz, A., Philippaert, K., Vennekens, R. (2014). TRPM4. In: Nilius, B., Flockerzi, V. (eds) Mammalian Transient Receptor Potential (TRP) Cation Channels. Handbook of Experimental Pharmacology, vol 222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54215-2_18

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