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The Essential Role of Calcium Phosphate Bioceramics in Bone Regeneration

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Advances in Calcium Phosphate Biomaterials

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 2))

Abstract

Various bioceramics or xenograft has been used to avoid autograft. However, there are large differences in the chemistry, the micro- and macrostructure, and consequently the performance in terms of resorption, absorption, and regeneration of physiological bone. The differences in such available bioceramics were reported and critical data presented. Recent developments related to CaP scaffolds including improvements in terms of engineering chemistry, surface properties, microstructure, and porosities, which lead them to be considered as being bioinstructive rather than osteoconductive scaffolds, have opened up new opportunities for bone regenerative technologies. Not only are some of these CaP bioceramics scaffolds osteoinductive in their own right, but evidence also supports the hypothesis that specific engineering bioceramics have a direct influence on the differentiation and proliferation of human mesenchymal stem cells (hMSCs). Tissue engineering, new bioactive molecules, and new surgical technologies increase the potential application of CaP bioceramics as carriers of these cells and also as scaffolds capable of guiding the behavior of these cells and the efficiency of bone regeneration. If the smart bioinstructive CaP scaffold technology led to a higher efficacy of CaP scaffolds, it would allow further surgical applications in bone tissue regeneration. The mechanical properties required for bone ingrowth and bone remodeling and mechanotransduction must be explored to allow for development of new generation scaffolds.

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Acknowledgments

We would like to thank the 7th framework program HEALTH-2009-1.4.2 of the European Commission on Regenerative Bone defects using New biomedical Engineering approaches (REBORNE project).

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Authors and Affiliations

  1. Faculté de Chirurgie Dentaire Pl A. Ricordeau, Inserm U791, University of Nantes and Inserm CIC-IT 802, Hospital of Bordeaux LIOAD Inserm Université de Nantes UMR U791, 44042, Nantes cedex, France

    Guy Daculsi

  2. Oniris, National Veterinary School, Nantes, France

    Borhane Hakim Fellah

  3. Faculté de Chirurgie Dentaire Pl A. Ricordeau, LIOAD Inserm Université de Nantes UMR U791, 44042, Nantes cedex, France

    Thomas Miramond

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  1. Guy Daculsi
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  2. Borhane Hakim Fellah
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  3. Thomas Miramond
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Correspondence to Guy Daculsi .

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Editors and Affiliations

  1. Chemistry and Forensic Science, University of Technology, Sydney, New South Wales, Australia

    Besim Ben-Nissan

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Daculsi, G., Fellah, B.H., Miramond, T. (2014). The Essential Role of Calcium Phosphate Bioceramics in Bone Regeneration. In: Ben-Nissan, B. (eds) Advances in Calcium Phosphate Biomaterials. Springer Series in Biomaterials Science and Engineering, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-53980-0_4

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