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Neue Virostatika: Acyclovir und Azidothymidin

  • Conference paper
Vorträge der XII. Fortbildungswoche der Dermatologischen Klinik und Poliklinik der Ludwig-Maximilians-Universität München in Verbindung mit dem Berufsverband der Deutschen Dermatologen e.V. vom 23. bis 28. Juli 1989

Part of the book series: Fortschritte der praktischen Dermatologie und Venerologie ((DERMATOLOGIE,volume 12))

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Zusammenfassung

Acyclovir, 9-(2-hydroxy-ethoxy-methyl)-guanin oder Acycloguanosin, zeichnet sich durch seine spezifische Wirkung auf Herpes simplex Virus (HSV) und Varizellen-Zoster-Virus (VZV) aus. Acyclovir (ACV) wird durch die HSV-spezifische Thymidinkinase über ACV-Mono- und -Diphosphat zum aktiven ACV-Triphosphat phosphoryliert, das in den virusbefallenen Zellen und nur dort akkumuliert. ACV-Triphosphat hemmt kompetitiv die HSV-spezifische DNA-Polymerase selektiv und führt als falscher Baustein in die Virus-DNA eingebaut zum Kettenabbruch. ACV ist weitgehend atoxisch.

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Literatur

  1. Anonymus (1989) Zidovudine in symptomless HIV infection. Lancet I: 415–416

    Google Scholar 

  2. Cobo LM, Foulks GN, Liesegang T (1986) Oral acyclovir in the treatment of acute herpes zoster ophthalmicus. Ophthalmology 93: 763–770

    PubMed  CAS  Google Scholar 

  3. Cooper DA (1989) Strategies to improve tolerance. Abstract, Retrovir (Zidovudine) and patient management, Montreal 4. Juni 1989

    Google Scholar 

  4. Dournon E, Rozenbaum W, Michon C et al. (1988) Effects of Zidovudine in 365 consecutive patients with AIDS or AIDS-related complex. Lancet II: 1297–1302

    Google Scholar 

  5. Fischl MA, Richman DD, Griego MH et al. (1987) The efficacy of Azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. N Engl J Med 317: 185–191

    Google Scholar 

  6. Fischl MA (1989) Survival of patients on long-term open Zidovudine. Abstract, Retrovir (Zidovudine) and patient management, Montreal 4. Juni 1989

    Google Scholar 

  7. Goldberg LH, Kaufman R, Conant MA et al. (1988) Episodic twice-daily treatment for recurrent genital herpes. Am J Med (Suppl 2A ) 85: 10–13

    Google Scholar 

  8. Horwitz JP, Chua J, Noel M (1964) Nucleosides. V. The monomesylates of 1-(2’ deoxy-B-Dlyxofuranosyl) thymidine. J Org Chem 29: 1076–2078

    Article  Google Scholar 

  9. Huff JC, Bean B, Balfour HH et al. (1988) Therapy of Herpes Zoster with oral Acyclovir. Am J Med 85 (Suppl 2A): 84–89

    PubMed  CAS  Google Scholar 

  10. Juel-Jensen BE (1983) High dose intravenous acyclovir in the treatment of zoster: A double-blind, placebo-controlled trial. J Infect 6 (Suppl 1): 31–36

    Article  PubMed  CAS  Google Scholar 

  11. Kinghorn GR, Turner EB, Barton IG et al. (1983) Efficacy of topical acyclovir cream in first and recurrent episodes of genital herpes. Antiviral Res 3: 291–301

    Article  PubMed  CAS  Google Scholar 

  12. Ledergerber B, Rufli Th (1988) Azidothymidin Swiss postmarketing surveillance study: Swiss study group for clinical studies on AIDS. Dermatologica 177: 255 (Abstract)

    Google Scholar 

  13. Leigh IM (1988) Management of non-genital herpes simplex virus infections in immunocompetent patients. Am J Med (Suppl 2A ) 85: 34–38

    Google Scholar 

  14. McKendrick MW, Care C, Burke C et al. (1984) Oral acyclovir in herpes zoster. J Antimicrob Chemother 14: 661–665

    Article  PubMed  CAS  Google Scholar 

  15. Mertz GJ, Critchlow CW, Benedetti J et al. (1984) Double blind placebo controlled trial of oral acyclovir in first-episode genital herpes simplex virus infection. JAMA 252: 1147–1151

    CAS  Google Scholar 

  16. Mertz GJ, Eron L, Kaufman R et al. (1988) Prolonged continuous versus intermittent oral acyclovir treatment in normal adults with frequently recurrent genital herpes simplex virus infection. Am J Med (Suppl 2A ) 85: 14–19

    Google Scholar 

  17. Mitsuya H, Weinhold KJ, Furman PA et al. (1985) 3’-Azido-3’-deoxythymidine (BW A509U) an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/Lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci USA 71: 4980–4985

    Google Scholar 

  18. Mostow SR, Mayfield JL, Marr JJ et al. (1988) Suppression of recurrent genital herpes by single daily dosages of acyclovir. Am J Med (Suppl 2A ) 85: 30–33

    Google Scholar 

  19. Niimura M (1988) Treatment of eczema herpeticum with oral acyclovir. Am J Med (Suppl 2A ) 86: 49–52

    Google Scholar 

  20. Nyerges G, Meszner Z (1988) Treatment of chickenpox in immunocompromised children. Am J Med (Suppl 2A ) 85: 94–95

    Google Scholar 

  21. Price RW (1989) Role of Zidovudine in the management of neurological complications of HIV-disease. Abstract, Retrovir (Zidovudine) and patient management. Montreal, 4. Juni 1989

    Google Scholar 

  22. Reichman RC, Badger GJ, Mertz GJ et al. (1984) Treatment of recurrent genital herpes simplex infections with oral acyclovir: a controlled trial. JAMA 251: 2103–2107

    CAS  Google Scholar 

  23. Rompalo AM, Mertz GJ, Davis G et al. (1988) Oral acyclovir for treatment of first-episode herpes simplex virus proctitis. JAMA 259: 2879–2881

    CAS  Google Scholar 

  24. Sarai R (1988) Management of mucocutaneous herpes simplex virus infections in immunocompromised patients. Am J Med (Suppl 2A ) 85: 57–60

    Google Scholar 

  25. Schmitt FA, Bigley JW, McKinnis R et al. (1988) Neuropsychological outcome of Zidovudine ( AZT) treatment of patients with AIDS and AIDS-related complex. N Engl J Med 319: 1573–1578

    Google Scholar 

  26. Schwab IR (1988) Oral acyclovir in the management of herpes simplex ocular infections. Ophthalmology 95: 423–430

    PubMed  CAS  Google Scholar 

  27. Spruance SL, Hamill ML, Hoge WS et al. (1988) Acyclovir perevents reactivation of herpes simplex labialis in skiers. JAMA 260: 1597–1599

    CAS  Google Scholar 

  28. The Swiss Group for Clinical Studies on the Acquired Immunodefficiency Syndrome (AIDS) (1988) Zidovudine for the treatment of Thrombocytopenia associated with human immunodeficiency virus (HIV). Ann Intern Med 109: 718–719

    Google Scholar 

  29. Wainberg MA, Falutz J, Fanning M et al. (1989) Cessation of Zidovudine therapy may lead to increases replication of HIV-1. JAMA 261: 865–866

    CAS  Google Scholar 

  30. Whitley RJ (1988) Herpes simplex virus infections of the central nervous system: A review. Am J Med (Suppl 2 A) 85: 61–67

    CAS  Google Scholar 

  31. Wood MJ, Ogan PH, McKendrick MW et al. (1988) Efficacy of oral acyclovir treatment of acute herpes zoster. Am J Med (Suppl 2A ) 85: 79–83

    Google Scholar 

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Authors
  1. Theo Rufli
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Editors and Affiliations

  1. Dermatologischen Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Frauenlobstraße 9-11, D-8000, München 2, Deutschland

    Otto Braun-Falco (o. ö. Professor für Dermatologie und Venerologie, Direktor) (o. ö. Professor für Dermatologie und Venerologie, Direktor)

  2. Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Frauenlobstraße 9-11, D-8000, München 2, Deutschland

    Johannes Ring

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© 1990 Springer-Verlag Berlin Heidelberg

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Rufli, T. (1990). Neue Virostatika: Acyclovir und Azidothymidin. In: Braun-Falco, O., Ring, J. (eds) Vorträge der XII. Fortbildungswoche der Dermatologischen Klinik und Poliklinik der Ludwig-Maximilians-Universität München in Verbindung mit dem Berufsverband der Deutschen Dermatologen e.V. vom 23. bis 28. Juli 1989. Fortschritte der praktischen Dermatologie und Venerologie, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48223-6_58

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  • DOI: https://doi.org/10.1007/978-3-642-48223-6_58

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51962-1

  • Online ISBN: 978-3-642-48223-6

  • eBook Packages: Springer Book Archive

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