Abstract
Although we don’t see how the recent data on multiple drug resistance is related to the mechanism of action of the penicillin-cephalosporin drugs, we feel that certain aspects of resistance development should be noted at this time. Ochiai et al. (1959) and Akiba (1959) independently reported the hereditary character of multiple drug resistance in strains of Enterobacteriaceae. The medical importance of the extrachromosomal episomal infective drug resistance transfer factors has only recently been emphasized (Walton, 1966; Kabins and Cohen, 1966). Penicillinase synthesis has been adequately demonstrated to be mediated via R-factor episomes in E. coli by Datta and Richmond (1966). How these infective transfer factors (R-factors) relate to the plasmids described in staphylococci is not clear but there are similarities in the conceptual status of these factors (Poston, 1966; Asheshov, 1966). The character of infectious drug resistance transfer in complex environments and during chemotherapeutic regimens between various bacterial species and their morphological variants appears to be a most vital area for intensive future research. For further consideration of these “current events” we refer the reader to Petrovskaya et al. (1964), Anderson (1965), Anderson and Lewis (1965), and De Courcy and Sevag (1966).
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Flynn, E.H. et al. (1967). Addenda. In: Gottlieb, D., Shaw, P.D. (eds) Mechanism of Action. Antibiotics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46051-7_65
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