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Prognostische Bedeutung von Apoptose-Induktoren/Inhibitoren in Magenkarzinom mit/ohne adjuvanter intraoperativer Radiotherapie (IORT)

Prognostic Implications of Apoptosis Inducers/Inhibitors in Gastric Cancer Patients Following Curative Resection With or Without Adjuvant Intraoperative Radiotherapy

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Vielfalt und Einheit der Chirurgie Humanität und Wissenschaft

Part of the book series: Langenbecks Archiv für Chirurgie ((KONGRESSBAND,volume 1998))

  • 19 Accesses

Summary

Several studies have tried to improve the surgical results after resection for gastric cancer by different adjuvant therapy protocols, including intraoperative radiotherapy (IORT). Since 1990 we have performed a randomized, prospective trial comparing surgery alone and surgery plus adjuvant IORT to evaluate the role of adjuvant intraoperative radiotherapy in the treatment of curative resected gastric carcinomas. In the present study, p53, bcl-2 immunoreactivity and DNA fragmentation as a typical marker of apoptosis were determined to investigate the predictive value of apoptosis-related factors and the observed response to radiotherapy. Preliminary data indicate that patients with tumors containing increased numbers of apoptotic tumor cells might derive benefit from adjuvant IORT.

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Literatur

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Authors and Affiliations

  1. Chirurgische Klinik, LMU München, Marchioninistraße 15, D-81377, München, Deutschland

    R. Kopp, H. J. Krämling & C. Cramer

  2. Klinikum Großhadern und Pathologisches Institut, LMU München, Marchioninistraße 15, D-81377, München, Deutschland

    J. Diebold, G. Baretton & F. W. Schildberg

Authors
  1. R. Kopp
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  2. H. J. Krämling
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  3. C. Cramer
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  4. J. Diebold
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  5. G. Baretton
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  6. F. W. Schildberg
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Editor information

Editors and Affiliations

  1. Deutschen Gesellschaft für Chirurgie, Steinhölzle 16, D-89197, Westerstetten-Vorderdenkental, Deutschland

    W. Hartel (Generalsekretär) (Generalsekretär)

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© 1998 Springer-Verlag Berlin Heidelberg

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Kopp, R., Krämling, H.J., Cramer, C., Diebold, J., Baretton, G., Schildberg, F.W. (1998). Prognostische Bedeutung von Apoptose-Induktoren/Inhibitoren in Magenkarzinom mit/ohne adjuvanter intraoperativer Radiotherapie (IORT). In: Hartel, W. (eds) Vielfalt und Einheit der Chirurgie Humanität und Wissenschaft. Langenbecks Archiv für Chirurgie, vol 1998. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45774-6_327

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  • DOI: https://doi.org/10.1007/978-3-642-45774-6_327

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65144-4

  • Online ISBN: 978-3-642-45774-6

  • eBook Packages: Springer Book Archive

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