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Hypothesis and Practice: Are There Several Types of Treatment for Ductal Carcinoma In Situ of the Breast?

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 152))

Abstract

The question is straightforward: Are there several types of treatment for ductal carcinoma in situ (DCIS) of the breast? If that question had been asked 15 or 20 years ago, the answer would have been a simple “no”. At that time, the heterogeneity of the disease was not widely appreciated and most patients with DCIS were treated with mastectomy. The answer today is just as simple, but it is now “yes” rather than no.

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References

  • Aasmundstad TA, Haugen OA (1992) DNA ploidy in intraductal breast carcinomas. Eur J Cancer 26:956–959

    Google Scholar 

  • Albertini JJ, Lyman GH, Cox C et al (1996) Lymphatic mapping and sentinel node biopsy in the patient with breast cancer. JAMA 276:1818–1822

    Article  PubMed  CAS  Google Scholar 

  • Ashikari R, Hadju SI, Robbins GF (1971) Intraductal carcinoma of the breast. Cancer 28:1182–1187

    Article  PubMed  CAS  Google Scholar 

  • Barnes DM, Meyer JS, Gonzalez JG, Gullick WJ, Millis RR (1991) Relationship between c-erbB-2 immunoreactivity and thymidine labelling index in breast carcinoma in situ. Breast Cancer Res Treat 18:11–17

    Article  PubMed  CAS  Google Scholar 

  • Bartkova J, Barnes DM, Millis RR, Gullick WJ (1990) Immunohistochemical demonstration of c-erbB-2 protein in mammary ductal carcinoma in situ. Hum Pathol 21:1164–1167

    Article  PubMed  CAS  Google Scholar 

  • Bellamy COC, McDonald C, Salter DM, Chetty U, Anderson TJ (1993) Noninvasive ductal carcinoma of the breast. The relevance of histologic categorization. Hum Pathol 24:16–23

    Article  PubMed  CAS  Google Scholar 

  • Dickson RB, Lippman ME (1995) Growth factors in breast cancer. Endocr Rev 16(5):559–589

    PubMed  CAS  Google Scholar 

  • Douglas-Jones AG, Gupta SK, Attanoos RL, Morgan JM, Mansel RE (1996) A critical appraisal of six modern classifications of ductal carcinoma in situ of the breast (DCIS): correlation with grade of associated invasive disease. Histopathology 29:397–409

    Article  PubMed  CAS  Google Scholar 

  • Ernster VL, Barclay J, Kerlikowske K et al (1996) Incidence of and treatment for ductal carcinoma in situ of the breast. JAMA 275:913–918

    Article  PubMed  CAS  Google Scholar 

  • Faverly DRG, Burgers L, Bult P, Holland R (1995) Three dimensional imaging of mammary ductal carcinoma in situ: clinical implications. Semin Diagn Pathol 11(3):193–198

    Google Scholar 

  • Fisher B, Costantino J, Redmond C et al (1993) Lumpectomy compared with lumpectomy and radiation therapy for the treatment of intraductal breast cancer. N Engl J Med 328:1581–1586

    Article  PubMed  CAS  Google Scholar 

  • Fisher B, Dignam J, Wolmark N et al (1998) Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17. J Clin Oncol 16:441–452

    PubMed  CAS  Google Scholar 

  • Fisher ER, Costantino J, Fisher B et al (1995) Pathologic finding from the National Surgical Adjuvant Breast Project (NSABP), protocol B-17: intraductal carcinoma (ductal carcinoma in situ). Cancer 75:1310–1319

    Article  PubMed  CAS  Google Scholar 

  • Fujii H, Marsh C, Cairns P et al (1996) Genetic divergence in the clonal evolution of breast cancer. Cancer Res 56:1493–1497

    PubMed  CAS  Google Scholar 

  • Giuliano AE, Dale PS, Turner RR, Morton DL, Evans SW, Krasne DL (1995) Improved axillary staging of breast cancer with sentinel lymphadenectomy. Ann Surg 222:394–401

    Article  PubMed  CAS  Google Scholar 

  • Hansen N, Giuliano A (1997) Axillary dissection for ductal carcinoma in situ. In: Silverstein MJ (ed) Ductal carcinoma in situ of the breast. Williams and Wilkins, Baltimore, pp 577–584

    Google Scholar 

  • Holland R, Faverly DRG (1997) Whole organ studies. In: Silverstein MJ (ed) Ductal carcinoma in situ of the breast. Williams and Wilkins, Baltimore, pp 233–240

    Google Scholar 

  • Jensen JA, Handel N, Silverstein MJ (1996) Glandular replacement therapy: an argument for a combined surgical approach in the treatment of noninvasive breast cancer. Breast 2:121–123

    Article  Google Scholar 

  • Krag DN, Weaver DL, Alex JC, Fairbank JT (1993) Surgical resection and radiolocalization of sentinel lymph node in breast cancer using a gamma probe. Surg Oncol 2:335–340

    Article  PubMed  CAS  Google Scholar 

  • Kroll SS, Ames F, Singletary SE et al (1991) The oncologic risks of skin preservation at mastectomy when combined with immediate reconstruction of the breast. Surg Gynecol Obstet 172:17–20

    PubMed  CAS  Google Scholar 

  • Lagios MD, Page DL (1993) Radiation therapy for in situ or localized breast cancer (Letter). N Engl J Med 21:1577–1578

    Google Scholar 

  • Lagios NM, Margolin FR, Westdahl PR, Rose NM (1989) Mammographically detected duct carcinoma in situ. Frequency of local recurrence following tylectomy and prognostic effect of nuclear grade on local recurrence. Cancer 63:619–624

    Article  Google Scholar 

  • Lakhani SR, Collins N, Stratton MR, Sloane JP (1995) Atypical ductal hyperplasia: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p. J Clin Pathol 48:611–615

    Article  PubMed  CAS  Google Scholar 

  • Lennington WJ, Jensen RA, Dalton LW, Page DL (1994) Ductal carcinoma in situ of the breast. Heterogeneity of individual lesions. Cancer 73:118–124

    Article  PubMed  CAS  Google Scholar 

  • Lippman ME (1993) The rational development of biological therapies for breast cancer. Science 259:631–632

    Article  PubMed  CAS  Google Scholar 

  • Meyer J (1986) Cell kinetics of histologic variants of in situ breast carcinoma. Breast Cancer Res Treat 7:171–180

    Article  PubMed  CAS  Google Scholar 

  • Nemoto T, Vana J, Bedwani RN, Baker HW, McGregor FH, Murphy GP (1980) Management and survival of female breast cancer: results of a national survey by the American College of Surgeons. Cancer 45:2917–2924

    Article  PubMed  CAS  Google Scholar 

  • Page DL, Lagios MD (1995) Pathologic analysis of the NSABP-B17 trial. Unanswered questions remaining unanswered considering current concepts of ductal carcinoma in situ. Cancer 75:1219–1222

    Article  PubMed  CAS  Google Scholar 

  • Page DL, Dupont WD, Rogers LW, Jensen RA, Schuyler PA (1995) Continued local recurrence of carcinoma 15–25 years after a diagnosis of low grade ductal carcinoma in situ of the breast treated only by biopsy. Cancer 76:1197–1200

    Article  PubMed  CAS  Google Scholar 

  • Parker SL, Tong T, Bolden S, Wingo PA (1997) Cancer statistics, 1997. CA Cancer J Clin 47:5–27

    Article  PubMed  CAS  Google Scholar 

  • Patchefsky AS, Schwartz GF, Finkelstein SD et al (1989) Heterogeneity of intraductal carcinoma of the breast. Cancer 63:731–741

    Article  PubMed  CAS  Google Scholar 

  • Radford DM, Phillips NJ, Fair KL et al (1995) Allelic loss and the progression of breast cancer. Cancer Res 55:5180–5183

    PubMed  CAS  Google Scholar 

  • Recht A (1997 a) Randomized trial overview. In: Silverstein MJ (ed) Ductal carcinoma in situ of the breast. Williams and Wilkins, Baltimore, pp 463–467

    Google Scholar 

  • Recht A (1997 b) Side effects of radiation therapy. In: Silverstein MJ (ed) Ductal carcinoma in situ of the breast. Williams and Wilkins, Baltimore, pp 347–352

    Google Scholar 

  • Schwartz GF (1994) The role of excision and surveillance alone in subclinical DCIS of the breast. Oncology 8(2):21–26

    PubMed  CAS  Google Scholar 

  • Schwartz GF, Lagios MD, Carter D et al (1998) Consensus conference on the classification of ductal carcinoma in situ. Cancer 80:1798–1802

    Google Scholar 

  • Silverstein MJ (ed) (1997 a) Ductal carcinoma in situ of the breast. Williams and Wilkins, Baltimore

    Google Scholar 

  • Silverstein MJ (1997 b) Predicting local recurrence in patients with ductal carcinoma in situ. In: Silverstein MJ (ed) Ductal carcinoma in situ of the breast. Williams and Wilkins, Baltimore, pp 271–284

    Google Scholar 

  • Silverstein MJ (1997 c) Van Nuys prognostic index for DCIS. In: Silverstein MJ (ed) Ductal carcinoma in situ of the breast. Williams and Wilkins, Baltimore, pp 491–504

    Google Scholar 

  • Silverstein MJ, Rosser RJ, Gierson ED et al (1987) Axillary dissection for intraductal breast carcinoma — is it indicated? Cancer 59:1819–1824

    Article  PubMed  CAS  Google Scholar 

  • Silverstein MJ, Poller DN, Waisman JR et al (1995 a) Prognostic classification of breast ductal carcinoma in situ. Lancet 345:1154–1157

    Article  PubMed  CAS  Google Scholar 

  • Silverstein MJ, Barth A, Poller DN et al (1995b) Ten-year results comparing mastectomy to excision and radiation therapy for ductal carcinoma in situ of the breast. Eur J Cancer 31:1425–1427

    Article  Google Scholar 

  • Silverstein MJ, Lagios MD, Craig PH et al (1996) A prognostic index for ductal carcinoma in situ of the breast. Cancer 77:2267–2274

    Article  PubMed  CAS  Google Scholar 

  • Silverstein MJ, Gamagami P, Colburn WJ (1997 a) Coordinated biopsy team: surgical, pathologic and radiologic issues. In: Silverstein MJ (ed) Ductal carcinoma in situ of the breast. Williams and Wilkins, Baltimore, pp 333–342

    Google Scholar 

  • Silverstein MJ, Lagios MD, Waisman JR et al (1997 b) Outcome after local recurrence for patients with ductal carcinoma in situ (DCIS) of the breast. Proc Am Soc Clin Oncol 16:129a

    Google Scholar 

  • Silverstein MJ, Lagios MD, Lewinsky BS et al (1997 c) Breast irradiation is unnecessary for widely excised ductal carcinoma in situ (DCIS) of the breast. Breast Cancer Res Treat 46:23

    Article  Google Scholar 

  • Silverstein MJ, Lagios MD, Waisman JR et al (1998 a) Margin width: a critical determinant of local control in patients with ductal carcinoma in situ (DCIS) of the breast. Proc Am Soc Clin Oncol 17:120a

    Google Scholar 

  • Silverstein MJ, Lagios MD, Martino S et al (1998 b) Outcome after local recurrence in patients with ductal carcinoma in situ of the breast. J Clin Oncol 16:1367–1373

    PubMed  CAS  Google Scholar 

  • Singletary ES (1995) Skin-sparing mastectomy with immediate breast reconstruction: is it safe? Breast Dis Yearbook Q 6:259–260

    Google Scholar 

  • Solin LJ, Yet I-T, Kurtz J et al (1993) Ductal carcinoma in situ (intraductal carcinoma) of the breast treated with breast-conserving surgery and definitive irradiation. Correlation of pathologic parameters with outcome of treatment. Cancer 71:2532–2542

    Article  PubMed  CAS  Google Scholar 

  • Solin LJ, Fourquet A, McCormick B et al (1994) Salvage treatment for local recurrence following breast conserving surgery and definitive irradiation for ductal carcinoma in situ (intraductal carcinoma) of the breast. Int J Radiat Oncol Biol Phys 30:3–9

    PubMed  CAS  Google Scholar 

  • Solin LJ, Kurtz J, Fourquet A et al (1996) Fifteen year results of breast conserving surgery and definitive breast irradiation for treatment of ductal carcinoma in situ of the breast. J Clin Oncol 14:754–763

    PubMed  CAS  Google Scholar 

  • Stratton MR, Collins N, Lakhani SR, Sloane JP (1995) Loss of heterozygosity in ductal carcinoma in situ of the breast. J Pathol 175:195–201

    Article  PubMed  CAS  Google Scholar 

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© 1998 Springer-Verlag Berlin · Heidelberg

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Silverstein, M.J., Masetti, R. (1998). Hypothesis and Practice: Are There Several Types of Treatment for Ductal Carcinoma In Situ of the Breast?. In: Senn, HJ., Gelber, R.D., Goldhirsch, A., Thürlimann, B. (eds) Adjuvant Therapy of Primary Breast Cancer VI. Recent Results in Cancer Research, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45769-2_10

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  • DOI: https://doi.org/10.1007/978-3-642-45769-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-45771-5

  • Online ISBN: 978-3-642-45769-2

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