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A New Function for Adenosine: Protection of Vascular Endothelial Cells from Neutrophil-Mediated Injury

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Topics and Perspectives in Adenosine Research

Summary

Activated neutrophils adhere to and injure endothelial cells by generating toxic oxygen metabolites. We have previously demonstrated that adenosine and its analogues inhibit generation of oxygen metabolites by stimulated neutrophils. Our data demonstrate that 2-chloroadenosine, a poorly metabolized adenosine receptor agonist, inhibits adherence of stimulated neutrophils to endothelial cells. We also found that 2-chloroadenosine prevents stimulated neutrophils from injuring endothelial cells. Adenosine is present in the medium of endothelial cells cultured with neutrophils. The adenosine present in the medium prevents both unstimulated and stimulated neutrophils from injuring endothelial cells. The results of these experiments suggest that adenosine may be a potent, endogenously derived anti-inflammatory agent.

Dr. Cronstein is a fellow of the Arthritis Foundation and is the recipient of Clinical Investigator Award K11AM0149001 from the National Institutes of Health. Dr. Levin is the recipient of Clinical Investigator Award K08HL00748 from the National Institutes of Health. This work was supported by grants from the New York Arthritis Foundation, the S.L.E. Foundation, the American Lung Association, the Rosenbloom Foundation, Johnson & Johnson, the Dana Trust, the Evans Foundation and NIH grants AJ10343, AM11949, HL19721 and AI17365.

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Authors and Affiliations

  1. Department of Medicine, Divisions of Rheumatology, Cardiology, and Medical Genetics, New York University Medical Center, 550 First Ave., New York, NY, 10016, USA

    B. N. Cronstein, R. I. Levin, J. Belanoff, G. Weissmann & R. Hirschhorn

Authors
  1. B. N. Cronstein
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  2. R. I. Levin
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  3. J. Belanoff
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  4. G. Weissmann
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  5. R. Hirschhorn
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Editor information

Editors and Affiliations

  1. Physiologisches Institut, Universität München, Pettenkoferstraße 12, 8000, München 2, Federal Republic of Germany

    Eckehart Gerlach  & Bernhard Friedrich Becker  & 

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© 1987 Springer-Verlag Berlin Heidelberg

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Cronstein, B.N., Levin, R.I., Belanoff, J., Weissmann, G., Hirschhorn, R. (1987). A New Function for Adenosine: Protection of Vascular Endothelial Cells from Neutrophil-Mediated Injury. In: Gerlach, E., Becker, B.F. (eds) Topics and Perspectives in Adenosine Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45619-0_24

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  • DOI: https://doi.org/10.1007/978-3-642-45619-0_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-45621-3

  • Online ISBN: 978-3-642-45619-0

  • eBook Packages: Springer Book Archive

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