Abstract
There have been at least two major concerns with use of HBOCs as resuscitation fluids for traumatic hemorrhage: potential coagulopathy and interference with conventional clinical laboratory coagulation measurements.
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Abe H, Fujihara M, Azuma H, Ikeda H, Ikebuchi K, Takeoka S, Tsuchida E, Harashima H (2006) Interaction of hemoglobin vesicles, a cellular-type artificial oxygen carrier with human plasma: effects on coagulation, kallikrein-kinin, and complement systems. Artif Cell Blood Substit Immobil Biotecnol 34(1):1–10
Arnaud F, Handrigan M (2006) Coagulation patterns following hemoglobin-based oxygen carrier resuscitation in severe uncontrolled hemorrhagic shock in swine. Transfusion Med 16:290–302
Arnaud F, Hammett M, Asher L, Philbin N, Rice J, Dong F, Pearce B, Flournoy WS, Nicholson C, McCarron R, Freilich D (2005) Effects of bovine polymerized hemoglobin on coagulation in controlled hemorrhagic shock in swine. Shock 24(2):145–152
Arnaud F, Fasipe D, Philbin N, Rice J, Flournoy WS, Ahlers A, James MF (2007) Hele′t E, Potgieter, Ellis P, McCarron R, Freilich D. Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care. Transfusion 47:2098–2109
Belgrave RL, Hines MT, Keegan RD, Wardrop KJ, Bayly WM, Sellon DC (2002) Effects of a polymerized ultrapurified bovine hemoglobin blood substitute administered to ponies with normovolemic anemia. J Vet Intern Med 16(4):396–403
Browdie D, Smith H (1975) Stroma-free hemoglobin. Simplied preparation and in vivo and in vitro effects on coagulation in rabbits. Am J Surg 129(4):365–368
Cabrales P, Sun G, Zhou Y, Harris DR, Tsai AG, Intaglietta M, Palmer AF (2009) Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction. J Appl Phys 107:1548–1558
Chen J-Y, Scerbo M, Kramer G (2009) A review of blood substitutes: examing the history, clinical trial results, and ethics of hemoglobin-based oxygen carriers. Clinics (São Paulo) 64:803–813
Dade PFA-100 Reagents Package Insert. Newark, DE: Dade Behring Inc; 2005
Darlington DN, Delgado AV, Kheirabadi BS, Fedyk CG, Scherer MR, Pusateri AE, Wade CE, Cap AP, Holcomb JB, Dubick MA (2011) Effect of hemodilution on coagulation and recombinant factor VIIa efficacy in human blood in vitro. J Trauma-injury Infect Crit Care 71:1152–1163
Deusch E, Gamsjager T, Kress HG et al (2003) Binding of hydroxyethyl starch molecules to the platelet surface. Anesth Analg 97:680–683
Ekseth K, Abildgaard L, Vegfors M, Berg-Johnsen J, Engdahl O (2002) The in vitro effects of crystalloids and colloids on coagulation. Anaesthesia 57:1102–1108
Favaloro EJ (2002) Clinical application of the PFA-100. Curr Opin Haematol 9:407–415
Feola M, Simoni J, Canizaro PT, Tran R. Raschbaum G, Behal FJ, Lubbock (1988) Texas. Toxicity of polymerized hemoglobin solutions. Surg Gynecol Obstet 166:211–222
Harrison P, Robinson M, Liesner R et al (2002) The PFA-100: a potential rapid screening tool for the assessment of platelet dysfunction. Clin Lab Haematol 4:225–232
Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB et al (2010) Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma 69(3):489–500
Huang Y, Komatsu T, Nakagawa A, Tsuchida E, Kobayashi S (2003) Compatibility in vitro of albumin-heme oxygen carrier with blood cell components. J Biomed Mater Res A 66(2):292–297
Huraux C, Ankri A, Eyraud D et al (2001) Hemostatic changes in patients receiving hydroxyethyl starch: The influence of ABO blood group. Anesth Analg 92:1396–1401
Iwasaki K, Iwashita Y, Ikeda K, Uematsu T (1986) Efficacy and saftey of hemoglobin-polyethlene glycol conjugate (pyridoxalated polyethylene glycol hemoglobin) as an oxygen-carrying resuscitation fluid. Artif Organs 10(6):470–474
Jahr JS, Lurie F, Gosselin R, Lin JS, Wong L, Owings JT, Larkin E (2002) Effects of hemoglobin glutamer-250 (bovine) (HBOC-201, Hemopure) on coagulation testing. Am J Ther 9:431–436
Jahr JS, Weeks DL, Desai P, Lim JC, Butch AW, Gunther RA, Driessen B (2008a) Does OxyVita, a new-generation hemoglobin-based oxygen carrier, or oxyglobin, acutely interfere with coagulation compared with normal saline or 6% hetastarch? An ex vivo thrombelastography study. J Cardiothorac Vasc Anesth 22:34–39
Jahr JS, Mackenzie C, Pearce B, Pitman A, Greenburg AG (2008b) HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. J Trauma-Injury Infect Crit Care 64(6):1484–1497
Jahr JS, Liu H, Albert O, Gull A, Moallempour M, Lim J, Gosselin R (2010) Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study? Am J Ther 17:140–147
Jahr JS, Sadighi A, Doherty L, Li A, Kim HW (2011) In chemistry and biochemistry of oxygen therapeutics: from transfusion to artificial blood. Mozzarelli A, Bettati S (eds) (2011) John Wiley and Sons, Ltd., pp 301–316
Jahr JS, Sadighi Akha A, Holtby R (2012) Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products. publ Curr Drug Discov Technol 9:158–65
James MF (2004) Hele′t E, Potgieter, Ellis P. The effect of hemopure on coagulation in clinically relevant concentrations. Anesth Analg 99(6):1593–1597
Jamnicki M, Bombeli T, Seifert B, Zollinger A, Camenzind V, Pasch T, Spahn DR (2000) Low- and medium-molecular-weight hydroxyethyl starches: comparison of their effect on blood coagulation. Anesthesiology 93(5):1231–1237
Johnson VV, Swiatkowski SA (2007) Scientific aspects of supplying blood to distant military theaters. Transfus Med 14:694–699
Kim HW, Greenburg AG (2006) Toward 21st century blood component replacement therapeutics: artificial oxygen carriers, platelet substitutes, recombinant clotting factors, and others. Artif blood Substit Immobil Biotechnol 34:537–550
Kim HW, Stubdal H, Greenburg AG (1992) Coagulation dynamics after hemodilution with polyhemoglobin. Surg Gynecol Obstet 175(219–26):22
Lee DH, Bardossy L, Peterson N, Blajchman MA (2000) O-raffinose cross-linked hemoglobin improves the hemostatic defect associated with anemia and thrombocytopenia in rabbits. Blood 96(10):3630–3636
Lefkowitz JB (2008) Coagulation pathway and physiology. In: Kottke-Marchant K (ed) An Algorithmic Approach to hemostasis testing. College of American Pathologists, Northfield, pp 3–12
Leytin V, Mazer D, Mody M, Garvey B, Freedman J (2003) Hemolink, an o-raffinose cross link haemoglobin-based oxygen carrier, does not affect activation and function of human platelets in whole blood. Br J Haematol 120(3):535–541
Mammen EF (1998) PFA-100 system: a new method for assesment of platelet dysfunction. Semin Thromb Haemost 24:195–202
Moallempour M, Jahr JS, Lim JC, Weeks D, Butch A, Driessen B (2009) Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model. J Cardiothorac Vasc Anesth 23(1):41–47
Ning J, Chang TM (1990) In vivo effects of stroma-free hemoglobin and polyhemoglobin on coagulation factors in rats. Int J Artif Organs 13(8):509–516
Reid TE (2003) Hb-based oxygen carriers: are we there yet? Transfusion 43:280–287
Sakai H, Hara H, Yuasa M, Tsai AG, Takeoka S, Tsuchida E, Intaglietta M (2002) Am J Phys-Heart Circ Phys 279:H908– H915
Savitsky JP, Doczi J, Black J, Arnold JD (1978) A clinical safety trial of stroma-free hemoglobin. Clin Pharmacol Ther 23(1):73–80
Saxena R, Wijnhoud AD, Carton H, Hacke W, Kaste M, Przybelski RJ, Stern KN, Koudstaa PJ (1999) Stroke 30:993–996
Squires JE (2002) Artificial Blood. Science 295:1002–1005
Standl T, Burmeister MA, Horn EP, Wilhelm S, Knoefel WT (1998) Schulte am Esch J. Bovine haemoglobin-based oxygen carrier for patients undergoing haemodilution before liver resection. Br J Anaesth 80(2):189–194
Strauss RG, Pennell BJ, Stump DC (2002) A randomized, blinded trial comparing the hemostatic effects of pentastarch versus hetastarch. Transfusion 42:27–36
TEG (2005) 5000 User’s manual. Niles, IL, Haemoscope Inc, P 178
Uszynski L, Schier J, Rudowski W, Daszynski J (1976) Effects of stroma-free haemoglobin solution on the blood-clotting system in dogs. Eur Surg Res 8(3):201–210
Weeks DL, Jahr JS, Lim JC, Butch AW, Driessen D (2008) Does Hextend® impair coagulation compared to 6% hetastarch: an ex vivo TEG study. Am J Ther 15:225–230
Williams JP, Tseuda K, Vandermeersch E, Bourke DL, Jahr JS (2002) Transfusion requirements in Phase III study of HBOC-201 (Hemopure®, Hemoglobin gutamer-250, bovine), a bovine hemoglobin based blood substitute. Transfusion 42:S49–030I
Winslow RM (2000) Blood Substitutes. Adv Drug Deliv Rev 40:131–142
Winslow RM (2003) Current status of blood substitute research: towards a new paradigm. J Intern Med 253:508–517
Wong NS, Chan TM (2007) Polyhemoglobin-fibrinogen: a novel oxygen carrier with platelet-like properties in a hemodiluted setting. Artif Cell Blood Substit Immobil Biotecnol 35(5):481–489
Zhang N, Jia Y, Chen G, Cabrales P, Palmer AF (2011) Tissue Eng Part A 17:927–940
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Jahr, J.S., Chung, M., Anvarhosseini, A., Kim, H.W. (2013). Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation. In: Kim, H., Greenburg, A. (eds) Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40717-8_34
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