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Adenom-Karzinom-Sequenz in zystischen Pankreasneoplasien

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Erkrankungen des Pankreas

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Zusammenfassung

Die muzinös-zystischen Neoplasien und die intraduktalen papillär-muzinösen Neoplasien weisen eine morphologisch gut charakterisierte Adenom-Karzinom-Sequenz auf, welche dreistufig eingeteilt wird. Auf dem Boden der dysplastischen Veränderungen in MCN und IPMN entstehen meistens Karzinome vom duktalen Typ. Eine Ausnahme bildet die IPMN vom intestinalen Typ, die meistens mit einem muzinösen (kolloid) Karzinom assoziiert ist. Die meisten bekannten genetischen Veränderungen in MCN und IPMN sind identisch mit denen im duktalen Adenokarzinom, ausgenommen das GNAS-Gen, welches unter den Pankreastumoren ausschließlich in IPMN mutiert ist. Die vier IPMN-Subtypen unterscheiden sich histogenetisch und klinisch markant. Allerdings fehlt uns derzeit das Verständnis für die molekularen Mechanismen, die diesen phänotypischen Unterschieden zugrunde liegen.

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Authors and Affiliations

  1. Institut für Pathologie und Neuropathologie Abteilung für Allgemeine Pathologie und Pathologische Anatomie, Universitätsklinikum Tübingen, Liebermeisterstraße 8, 72076, Tübingen, Deutschland

    Bence Sipos

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  1. Bence Sipos
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Correspondence to Bence Sipos .

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Editors and Affiliations

  1. Abt. Allgemeine- und Visceralchirurgie, Universitätsklinikum Ulm, Germany

    Hans G. Beger

  2. Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Heidelberg, Germany

    Markus W. Büchler

  3. Allgemein-, Viszeral- und Gefäßchirurgie, Universitätsklinikum Halle, Sachsen-Anhalt, Germany

    Henning Dralle

  4. Klinik und Poliklinik für Innere Medizin, Universitätsmedizin Greifswald, Germany

    Markus M. Lerch

  5. und Hepatologie (KGHI), Universitätsklinikum Magdeburg, Germany

    Peter Malfertheiner

  6. FB Gastroenterologie und Hepatologie, Universitätsklinikum Leipzig, Sachsen, Germany

    Joachim Mössner

  7. ehemals Klinikum der Stadt Ludwigshafen gGmbH, Rheinland-Pfalz, Germany

    Jürgen F. Riemann

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Sipos, B. (2013). Adenom-Karzinom-Sequenz in zystischen Pankreasneoplasien. In: Beger, H., et al. Erkrankungen des Pankreas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37964-2_49

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  • DOI: https://doi.org/10.1007/978-3-642-37964-2_49

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