Skip to main content

Intracranial Arterial Aneurysmal Disease in Childhood

  • Reference work entry
  • First Online:
PanVascular Medicine

Abstract

Epidemiological studies have revealed that intracranial arterial aneurysms (IAAs) are responsible for 10–15 % of hemorrhagic stroke in children and young adults. If one differentiates the pattern and location of intracranial hemorrhage, the importance of IAAs as a cause of hemorrhagic stroke in children is even more apparent. For example, IAAs account for as much as 57 % of pure spontaneous SAH in the pediatric population. In the non-adult population, the incidence of hemorrhagic stroke due to IAAs is highest in patients 15–19 years of age. This is more than five times that observed in younger age groups. It has been proposed that conventional vascular risk factors, such as tobacco use and cocaine abuse, are introduced in late adolescence and likely account for the sharp increase in aneurysmal disease in the latter half of the second decade (Jordan et al. 2009).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 649.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 549.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Abruzzo TA, DiNapoli V, Rahme R, Patel B, O’Brien K, Jimenez L, Shivashankar R, Leach J, Bissler JJ, Jones B (2013) Intracranial arterial aneurysms in children and young adults. J Pediatr Neuroradiol 2(3):203–235

    Google Scholar 

  • Aeron G, Abruzzo TA, Jones BV (2012) Clinical and imaging features of intracranial arterial aneurysms in the pediatric population. Radiographics 32:667–681

    Article  PubMed  Google Scholar 

  • Agid R, Lee SK, Willinsky RA, Farb RI, terBrugge KG (2005) The role of endovascular treatment for pediatric aneurysms. Childs Nerv Syst 21(12):1030–1036

    Article  PubMed  Google Scholar 

  • Agid R, Jonas Kimchi T, Lee SK, Ter Brugge KG (2007) Diagnostic characteristics and management of intracranial aneurysms in children. Neuroimag Clin N Am 17:153–156

    Article  Google Scholar 

  • Allen LM, Fowler AM, Walker C, et al (2012) Retrospective review of cerebral mycotic aneurysms in 26 patients: Focus on treatment in strongly immunocompromised patients with a brief literature review. AJNR Am J Neuroradiol 34(4):823–827

    Article  PubMed  Google Scholar 

  • Anderson RC, McDowell MM, Kellner CP et al (2012) Arteriovenous malformation-associated aneurysms in the pediatric population. J Neurosurg Pediatr 9:11–16

    Article  PubMed  Google Scholar 

  • Appelboom G, Kadri K, Hassan F, Leclerc X (2010) Infectious aneurysm of the cavernous carotid artery in a child treated with a new-generation of flow-diverting stent graft: case report. Neurosurgery 66:E623–E624

    Article  PubMed  Google Scholar 

  • Arambepola PK, McEvoy SD, Bulsara KR (2010) De novo aneurysm formation after carotid artery occlusion for cerebral aneurysms. Skull Base 20:405–408

    Article  PubMed  PubMed Central  Google Scholar 

  • Augoustides JG, Andritsos M (2010) Innovations in aortic disease: the ascending aorta and aortic arch. J Cardiothorac Vasc Anesth 24:198–207

    Article  PubMed  Google Scholar 

  • Bederson JB, Awad IA, Wiebers DO et al (2000) Recommendations for the management of patients with unruptured intracranial aneurysms: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke 31:2742–2750

    Article  CAS  PubMed  Google Scholar 

  • Berge J, Tourdias T, Moreau JF, Barreau X, Dousset V (2011) Perianeurysmal brain inflammation after flow-diversion treatment. AJNR Am J Neuroradiol 32:1930–1934

    Article  CAS  PubMed  Google Scholar 

  • Bonkowsky JL, Christenson JC, Nixon GW, Pavia AT (2002) Cerebral aneurysms in a child with acquired immune deficiency syndrome during rapid immune reconstitution. J Child Neurol 17:457–460

    Article  PubMed  Google Scholar 

  • Broderick JP, Sauerbeck LR, Foroud T et al (2005) The familial intracranial aneurysm (FIA) study protocol. BMC Med Genet 6:17

    Article  PubMed  PubMed Central  Google Scholar 

  • Bromberg JE, Rinkel GJ, Algra A et al (1995) Subarachnoid haemorrhage in first and second degree relatives of patients with subarachnoid haemorrhage. BMJ 311:288–289

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brown RD Jr, Wiebers DO, Forbes GS (1990) Unruptured intracranial aneurysms and arteriovenous malformations: frequency of intracranial hemorrhage and relationship of lesions. J Neurosurg 73:859–863

    Article  PubMed  Google Scholar 

  • Brown RD Jr, Huston J, Hornung R et al (2008) Screening for brain aneurysm in the familial intracranial aneurysm study: frequency and predictors of lesion detection. J Neurosurg 108:1132–1138

    Article  PubMed  PubMed Central  Google Scholar 

  • Buis DR, van Ouwerkerk WJ, Takahata H, Vandertop WP (2006) Intracranial aneurysms in children under 1 year of age: a systematic review of the literature. Childs Nerv Syst 22:1395–1409

    Article  CAS  PubMed  Google Scholar 

  • Burger IM, Murphy KJ, Jordan LC, Tamargo RJ, Gailloud P (2006) Safety of cerebral digital subtraction angiography in children: complication rate analysis in 241 consecutive diagnostic angiograms. Stroke 37:2535–2539

    Article  PubMed  Google Scholar 

  • Chang IB, Cho BM, Park SH, Yoon DY, Oh SM (2008) Metastatic choriocarcinoma with multiple neoplastic intracranial microaneurysms: case report. J Neurosurg 108:1014–1017

    Article  PubMed  Google Scholar 

  • Ducruet AF, Hickman ZL, Zacharia BE et al (2010) Intracranial infectious aneurysms: a comprehensive review. Neurosurg Rev 33:37–46

    Article  PubMed  Google Scholar 

  • Fiorella D, Woo HH, Albuquerque FC, Nelson PK (2008) Definitive reconstruction of circumferential, fusiform intracranial aneurysms with the pipeline embolization device. Neurosurgery 62:1115–1121

    Article  PubMed  Google Scholar 

  • Fischer BR, Palkovic S, Holling M, Niederstadt T, Jeibmann A, Wassmann H (2009) Coexistence of cerebral aneurysm and meningioma–pure accident? Clin Neurol Neurosurg 111:647–654

    Article  CAS  PubMed  Google Scholar 

  • Friefeld SJ, Westmacott R, Macgregor D, Deveber GA (2011) Predictors of quality of life in pediatric survivors of arterial ischemic stroke and cerebral sinovenous thrombosis. J Child Neurol 26:1186–1192

    Article  PubMed  Google Scholar 

  • Greeley A, Abruzzo T, Jones B, Zumberge N (2007) Intracranial arterial aneurysms in the pediatric population. Presented at the annual meeting of the American Society of Neuroradiology, Chicago, June 2007

    Google Scholar 

  • Harrod CG, Batjer HH, Bendok BR (2006) Deficiencies in estrogen-mediated regulation of cerebrovascular homeostasis may contribute to an increased risk of cerebral aneurysm pathogenesis and rupture in menopausal and postmenopausal women. Med Hypotheses 66:736–756

    Article  CAS  PubMed  Google Scholar 

  • Hetts SW, Narvid J, Sanai N et al (2009) Intracranial aneurysms in childhood: 27-year single-institution experience. AJNR Am J Neuroradiol 30:1315–1324

    Article  CAS  PubMed  Google Scholar 

  • Hetts SW, English JD, Dowd CF, Higashida RT, Scanlon JT, Halbach VV (2011) Pediatric intracranial aneurysms: new and enlarging aneurysms after index aneurysm treatment or observation. AJNR Am J Neuroradiol 32:2017–2022

    Article  CAS  PubMed  Google Scholar 

  • Housepian EM, Pool JL (1958) A systematic analysis of intracranial aneurysms from the autopsy file of the Presbyterian Hospital, 1914 to 1956. J Neuropathol Exp Neurol 17:409–423

    Article  CAS  PubMed  Google Scholar 

  • Huang J, McGirt MJ, Gailloud P, Tamargo RJ (2005) Intracranial aneurysms in the pediatric population: case series and literature review. Surg Neurol 63:424–3

    Article  PubMed  Google Scholar 

  • Husson RN, Saini R, Lewis LL, Butler KM, Patronas N, Pizzo PA (1992) Cerebral artery aneurysms in children infected with human immunodeficiency virus. J Pediatr 121:927–930

    Article  CAS  PubMed  Google Scholar 

  • Imamura J, Okuzono T, Okuzono Y (1998) Fatal epistaxis caused by rupture of an intratumoral aneurysm enclosed by a large prolactinoma–case report. Neurol Med Chir 38:654–656

    Article  CAS  Google Scholar 

  • Jakubowski J, Kendall B (1978) Coincidental aneurysms with tumours of pituitary origin. J Neurol Neurosurg Psychiatry 41:972–979

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jean WC, Walski-Easton SM, Nussbaum ES (2001) Multiple intracranial aneurysms as delayed complications of an atrial myxoma: case report. Neurosurgery 49:200–202, discussion 2–3

    CAS  PubMed  Google Scholar 

  • Jian BJ, Hetts SW, Lawton MT, Gupta N (2010) Pediatric intracranial aneurysms. Neurosurg Clin N Am 21(3):491–501

    Article  PubMed  Google Scholar 

  • Jordan LC, Johnston SC, Wu YW, Sidney S, Fullerton HJ (2009) The importance of cerebral aneurysms in childhood hemorrhagic stroke: a population-based study. Stroke 40:400–405

    Article  PubMed  Google Scholar 

  • Kadkhodayan Y, Shetty VS, Blackburn SL, Reynolds MR, Cross DT 3rd, Moran CJ (2012) Pipeline embolization device and subsequent vessel sacrifice for treatment of a bleeding carotid pseudoaneurysm at the skull base: a case report. J Neurointerven Surg 4(5):368–374

    Article  Google Scholar 

  • Kakarla UK, Beres EJ, Ponce FA, Chang SW, Deshmukh VR, Bambakidis NC, Zabramski JM, Spetzler RF (2010) Microsurgical treatment of pediatric intracranial aneurysms: long-term angiographic and clinic outcomes. Neurosurgery 67(2):237–249

    Article  PubMed  Google Scholar 

  • Kannoth S, Thomas SV (2009) Intracranial microbial aneurysm (infectious aneurysm): current options for diagnosis and management. Neurocrit Care 11:120–129

    Article  PubMed  Google Scholar 

  • Kannoth S, Iyer R, Thomas SV et al (2007) Intracranial infectious aneurysm: presentation, management and outcome. J Neurol Sci 256:3–9

    Article  PubMed  Google Scholar 

  • Kassell NF, Torner JC, Haley EC Jr, Jane JA, Adams HP, Kongable GL (1990a) The international cooperative study on the timing of aneurysm surgery. Part 1: overall management results. J Neurosurg 73:18–36

    Article  CAS  PubMed  Google Scholar 

  • Kassell NF, Torner JC, Jane JA, Haley EC Jr, Adams HP (1990b) The international cooperative study on the timing of aneurysm surgery. Part 2: surgical results. J Neurosurg 73:37–47

    Article  CAS  PubMed  Google Scholar 

  • Kissela BM, Sauerbeck L, Woo D et al (2002) Subarachnoid hemorrhage: a preventable disease with a heritable component. Stroke 33:1321–1326

    Article  PubMed  Google Scholar 

  • Koroknay-Pal P, Lehto H, Niemela M, Kivisaari R, Hernesniemi J (2012a) Long-term outcome of 114 children with cerebral aneurysms. J Neurosurg Pediatr 9:636–645

    Article  PubMed  Google Scholar 

  • Koroknay-Pal P, Laakso A, Lehto H et al (2012b) Long-term excess mortality in pediatric patients with cerebral aneurysms. Stroke 43:2091–2096

    Article  PubMed  Google Scholar 

  • Krings T, Geibprasert S, terBrugge KG (2010) Pathomechanisms and treatment of pediatric aneurysms. Childs Nerv Syst 26:1309–1318

    Article  PubMed  Google Scholar 

  • Lasjaunias P, Wuppalapati S, Alvarez H, Rodesch G, Ozanne A (2005) Intracranial aneurysms in children aged under 15 years: review of 59 consecutive children with 75 aneurysms. Childs Nerv Syst 21:437–450

    Article  PubMed  Google Scholar 

  • Levitt MR, Morton RP, Mai JC, Ghodke B, Hallam DK (2012) Endovascular treatment of intracranial aneurysms in Loeys-Dietz syndrome. J Neurointerv Surg 4:e37

    Article  PubMed  Google Scholar 

  • Liang J, Bao Y, Zhang H et al (2009) The clinical features and treatment of pediatric intracranial aneurysm. Childs Nerv Syst 25:317–324

    Article  PubMed  Google Scholar 

  • Liaquat I, Murphy M, Bassi S, Bullock PR (2010) Paediatric and adult vascular intracranial complications of sickle-cell disease. Acta Neurochir 152:1175–1179

    Article  PubMed  Google Scholar 

  • Lv X, Jiang C, Li Y, Yang X, Wu Z (2009) Endovascular treatment for pediatric intracranial aneurysms. Neuroradiology 51(11):749–754

    PubMed  Google Scholar 

  • McDougall CG, Spetzler RF, Zabramski JM et al (2012) The barrow ruptured aneurysm trial. J Neurosurg 116:135–144

    Article  PubMed  Google Scholar 

  • McQuaker IG, Jaspan T, McConachie NS, Dolan G (1999) Coil embolization of cerebral aneurysms in patients with sickling disorders. Br J Haematol 106:388–390

    Article  CAS  PubMed  Google Scholar 

  • Meisel HJ, Mansmann U, Alvarez H, Rodesch G, Brock M, Lasjaunias P (2000) Cerebral arteriovenous malformations and associated aneurysms: analysis of 305 cases from a series of 662 patients. Neurosurgery 46:793–802

    CAS  PubMed  Google Scholar 

  • Mizutani T, Kojima H (2000) Clinicopathological features of non-atherosclerotic cerebral arterial trunk aneurysms. Neuropathology 20:91–97

    Article  CAS  PubMed  Google Scholar 

  • Molyneux A, Kerr R, Stratton I et al (2002) International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet 360:1267–1274

    Article  PubMed  Google Scholar 

  • Nahed BV, Bydon M, Ozturk AK, Bilguvar K, Bayrakli F, Gunel M (2007) Genetics of intracranial aneurysms. Neurosurgery 60:213–226

    Article  PubMed  Google Scholar 

  • Nakagawa T, Onozuka S, Mayanagi K (2001) Two cases of hemorrhage in benign brain tumors during systemic heparinization. Interv Neuroradiol 7:127–130

    CAS  PubMed  PubMed Central  Google Scholar 

  • O’Brien K, Leach J, Jones B, Bissler J, Zuccarello M, Abruzzo T (2013) Calcifications associated with pediatric intracranial arterial aneurysms: incidence and correlation with pathogenetic subtypes. Childs Nerv Syst 29(4):643–649

    Article  PubMed  Google Scholar 

  • Ostergaard JR, Boldby B (1983) Intracranial aneurysms in children and adolescents. J Neurosurg 48:832–837

    Article  Google Scholar 

  • Ostergaard JR, Voldby B (1983) Intracranial arterial aneurysms in children and adolescents. J Neurosurg 58:832–837

    Article  CAS  PubMed  Google Scholar 

  • Patsalides AD, Wood LV, Atac GK, Sandifer E, Butman JA, Patronas NJ (2002) Cerebrovascular disease in HIV-infected pediatric patients: neuroimaging findings. AJR Am J Roentgenol 179:999–1003

    Article  PubMed  Google Scholar 

  • Peerless SJ, Nemoto S, Drake CG (1983) Giant intracranial aneurysms in children and adolescents. In: Edwards MSB, Hoffman HJ (eds) Cerebral vascular disease in children and adolescents. Williams and Wilkins, Baltimore

    Google Scholar 

  • Pia HW, Obrador S, Martin JG (1972) Association of brain tumours and arterial intracranial aneurysms. Acta Neurochir 27:189–204

    Article  CAS  PubMed  Google Scholar 

  • Proust F, Toussaint P, Garnieri J, Hannequin D, Legars D, Houtteville JP, Freger P (2001) Pediatric cerebral aneurysms. J Neurosurg 94(5):733–739

    CAS  PubMed  Google Scholar 

  • Pumar JM, Garcia-Dorrego R, Nieto A, Vazquez-Herrero F, Blanco-Ulla M, Vazquez-Martin A (2010) Vascular reconstruction of a fusiform basilar aneurysm with the silk embolization system. J Neurointerv Surg 2:242–244

    Article  CAS  PubMed  Google Scholar 

  • Racadio JM, Kashinkunti SR, Nachabe RA, Racadio JM, Johnson ND, Kukreja KU, Patel MN, Privitera MB, Hales JE, Abruzzo TA (2013) Clinically useful dilution factors for iodine and gadolinium contrast material: an animal model of pediatric digital subtraction angiography using state-of-the-art flat-panel detectors. Pediatr Radiol 43(11):1491–1501. doi:10.1007/s00247-013-2723-0. (Epub 2013 Jun 5)

    Article  PubMed  Google Scholar 

  • Rahme RJ, Adel JG, Bendok BR, Bebawy JF, Gupta DK, Batjer HH (2011) Association of intracranial aneurysm and Loeys-Dietz syndrome: case illustration, management, and literature review. Neurosurgery 69:E488–E493

    Article  PubMed  Google Scholar 

  • Ray WZ, Diringer MN, Moran CJ, Zipfel GJ (2010) Early endovascular coiling of posterior communicating artery saccular aneurysm in the setting of Staphylococcus bacteremia: case report and review of the literature. Neurosurgery 66:E847

    Article  PubMed  Google Scholar 

  • Redekop G, TerBrugge K, Montanera W, Willinsky R (1998) Arterial aneurysms associated with cerebral arteriovenous malformations: classification, incidence, and risk of hemorrhage. J Neurosurg 89:539–546

    Article  CAS  PubMed  Google Scholar 

  • Rinne JK, Hernesniemi JA (1993) De novo aneurysms: special multiple intracranial aneurysms. Neurosurgery 33:981–985

    Article  CAS  PubMed  Google Scholar 

  • Ross AC, Rizk N, O’Riordan MA et al (2009) Relationship between inflammatory markers, endothelial activation markers, and carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy. Clin Infect Dis 49:1119–1127

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Saraf R, Shrivastava M, Siddhartha W, Limaye U (2012) Intracranial pediatric aneurysms: endovascular treatment and its outcome. J Neurosurg Pediatr 10:230–240

    Article  PubMed  Google Scholar 

  • Shah SS, Zimmerman RA, Rorke LB, Vezina LG (1996) Cerebrovascular complications of HIV in children. AJNR Am J Neuroradiol 17:1913–1917

    CAS  PubMed  Google Scholar 

  • Shih TY, Kuo YL (2002) Development of intracranial complications following transoral stab wounds in children. Pediatr Neurosurg 37:35–37

    Article  PubMed  Google Scholar 

  • Siddiqui AH, Kan P, Abla AA, Hopkins LN, Levy EI (2012) Complications after treatment with pipeline embolization for giant distal intracranial aneurysms with or without coil embolization. Neurosurgery 71:E509–E513

    Article  PubMed  Google Scholar 

  • Soni A, De Silva SR, Allen K, Byrne JV, Cudlip S, Wass JA (2008) A case of macroprolactinoma encasing an internal carotid artery aneurysm, presenting as pituitary apoplexy. Pituitary 11:307–311

    Article  PubMed  Google Scholar 

  • Sprengers ME, van Rooij WJ, Sluzewski M et al (2009) MR angiography follow-up 5 years after coiling: frequency of new aneurysms and enlargement of untreated aneurysms. AJNR Am J Neuroradiol 30:303–307

    Article  CAS  PubMed  Google Scholar 

  • Stehbens WB (1963) Aneurysms and anatomical variations of cerebral arteries. Arch Pathol 75:45–64

    CAS  PubMed  Google Scholar 

  • Takao H, Nojo T, Ohtomo K (2008) Screening for familial intracranial aneurysms: decision and cost-effectiveness analysis. Acad Radiol 15:462–471

    Article  PubMed  Google Scholar 

  • Tanaka S, Sagiuchi T, Kobayashi I (2007) Ruptured pediatric posterior cerebral artery aneurysm 9 years after the onset of Kawasaki disease: a case report. Childs Nerv Syst 23:701–706

    Article  PubMed  Google Scholar 

  • Tawk RG, Villalobos HJ, Levy EI, Hopkins LN (2006) Surgical decompression and coil removal for the recovery of vision after coiling and proximal occlusion of a clinoidal segment aneurysm: technical case report. Neurosurgery 58:E1217

    Article  PubMed  Google Scholar 

  • Turner RD, Byrne JV, Kelly ME et al (2008) Delayed visual deficits and monocular blindness after endovascular treatment of large and giant paraophthalmic aneurysms. Neurosurgery 63:469–475

    Article  PubMed  Google Scholar 

  • Van der Born IMJ, Hou SY, Puri AS, Spilberg G, Ruijters D, van de Haar P, Carelesen B, Vedantham S, Gounis MJ, Wakhloo AK (2013) Reduction of coil mass artifacts in high-resolution flat panel detector conebeam CT of cerebral stent assisted coiling. AJNR Am J Neuroradiol 34(11):2163–2170

    Article  Google Scholar 

  • van Doormaal TP, van der Zwan A, Verweij BH, Han KS, Langer DJ, Tulleken CA (2008) Treatment of giant middle cerebral artery aneurysms with a flow replacement bypass using the excimer laser-assisted nonocclusive anastomosis technique. Neurosurgery 63:12–20, discussion −2

    Article  PubMed  Google Scholar 

  • Ventureyra EC, Higgins MJ (1994) Traumatic intracranial aneurysms in childhood and adolescence. Case reports and review of the literature. Childs Nerv Syst 10:361–379

    Article  CAS  PubMed  Google Scholar 

  • Wakai S, Fukushima T, Furihata T, Sano K (1979) Association of cerebral aneurysm with pituitary adenoma. Surg Neurol 12:503–507

    CAS  PubMed  Google Scholar 

  • Wehman JC, Hanel RA, Levy EI, Hopkins LN (2006) Giant cerebral aneurysms: endovascular challenges. Neurosurgery 59:S125–S138, discussion S3–13

    Article  PubMed  Google Scholar 

  • Weir B (1992) Pituitary tumors and aneurysms: case report and review of the literature. Neurosurgery 30:585–591

    Article  CAS  PubMed  Google Scholar 

  • Wermer MJH, van der Schaaf IC, Velthuis BK, Algra A, Buskens E, Rinkel GJE (2005) Follow-up screening after subarachnoid hemorrhage: frequency and determinants of new aneurysms and enlargement of existing aneurysms. Brain 128:2421–2429

    Article  CAS  PubMed  Google Scholar 

  • Wiebers DO, Whisnant JP, Huston J 3rd et al (2003) Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 362:103–110

    Article  PubMed  Google Scholar 

Further Reading

  • Amin-Hanjani S, Ogilvy CS, Buonanno FS, Choi IS, Metz LN (1997) Treatment of dissecting basilar artery aneurysm by flow reversal. Acta Neurochir 139:44–51

    Article  CAS  PubMed  Google Scholar 

  • Anson JA, Koshy M, Ferguson L, Crowell RM (1991) Subarachnoid hemorrhage in sickle-cell disease. J Neurosurg 75:552–558

    Article  CAS  PubMed  Google Scholar 

  • Aoun SG, Soltanolkotabi M, Ansari SA, Marden FA, Batjer HH, Bendok BR (2012) Ruptured spinal artery aneurysm associated with coarctation of the aorta: case report and literature review. World Neurosurg 2014 81(2):441e17–22

    Article  Google Scholar 

  • Aviv RI, Benseler SM, Silverman ED et al (2006) MR imaging and angiography of primary CNS vasculitis of childhood. AJNR Am J Neuroradiol 27:192–199

    CAS  PubMed  Google Scholar 

  • Barbalho JC, Santos ES, Menezes JM Jr, Goncalves FR, Chagas OL Jr (2010) Treatment of pseudoaneurysm of internal maxillary artery: a case report. Craniomaxillofac Trauma Reconstr 3:87–89

    Article  PubMed  PubMed Central  Google Scholar 

  • Baskaya MK, Uluc K (2012) Application of a new fenestrated clip (Yasargil T-bar clip) for the treatment of fusiform M1 aneurysm: case illustration and technical report. Neurosurgery 70:339–342

    PubMed  Google Scholar 

  • Belcher JD, Beckman JD, Balla G, Balla J, Vercellotti G (2010) Heme degradation and vascular injury. Antioxid Redox Signal 12:233–248

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Beltramello A, Puppini G, Bricolo A et al (1999) Does the tuberous sclerosis complex include intracranial aneurysms? A case report with a review of the literature. Pediatr Radiol 29:206–211

    Article  CAS  PubMed  Google Scholar 

  • Berger JR, Dillon DA, Young BA, Goldstein SJ, Nelson P (2009) Cystinosis of the brain and spinal cord with associated vasculopathy. J Neurol Sci 284:182–185

    Article  PubMed  Google Scholar 

  • Berkun Y, Elami A, Meir K, Mevorach D, Naparstek Y (2004) Increased morbidity and mortality in patients with antiphospholipid syndrome undergoing valve replacement surgery. J Thorac Cardiovasc Surg 127:414–420

    Article  PubMed  Google Scholar 

  • Brandao RA, de Carvalho GT, Reis BL, Bahia E, de Souza AA (2009) Intracranial aneurysms in sickle cell patients: report of 2 cases and review of the literature. Surg Neurol 72:296–299

    Article  PubMed  Google Scholar 

  • Broderick JP, Viscoli CM, Brott T et al (2003) Major risk factors for aneurysmal subarachnoid hemorrhage in the young are modifiable. Stroke 34:1375–1381

    Article  PubMed  Google Scholar 

  • Cantez S, Benseler SM (2008) Childhood CNS vasculitis: a treatable cause of new neurological deficit in children. Nat Clin Pract Rheumatol 4:460–461

    Article  PubMed  Google Scholar 

  • Capaldo B, Guardasole V, Pardo F et al (2001) Abnormal vascular reactivity in growth hormone deficiency. Circulation 103:520–524

    Article  CAS  PubMed  Google Scholar 

  • Cebral JR, Mut F, Raschi M et al (2011) Aneurysm rupture following treatment with flow-diverting stents: computational hemodynamics analysis of treatment. AJNR Am J Neuroradiol 32:27–33

    Article  CAS  PubMed  Google Scholar 

  • Chakrabortty S, Tamaki N, Kondoh T, Kojima N, Kamikawa H, Matsumoto S (1991) Maffucci’s syndrome associated with intracranial enchondroma and aneurysm: case report. Surg Neurol 36:216–220

    Article  CAS  PubMed  Google Scholar 

  • Chun JY, Smith W, Halbach VV, Higashida RT, Wilson CB, Lawton MT (2001) Current multimodality management of infectious intracranial aneurysms. Neurosurgery 48:1203–1214

    CAS  PubMed  Google Scholar 

  • Coutard M, Osborne-Pellegrin M (1991) Rupture of the internal elastic lamina and vascular fragility in stroke-prone spontaneously hypertensive rats. Stroke 22:510–515

    Article  CAS  PubMed  Google Scholar 

  • Crosnier C, Attie-Bitach T, Encha-Razavi F et al (2000) JAGGED1 gene expression during human embryogenesis elucidates the wide phenotypic spectrum of Alagille syndrome. Hepatology 32:574–581

    Article  CAS  PubMed  Google Scholar 

  • Csiszar A, Labinskyy N, Perez V et al (2008) Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice. Am J Physiol Heart Circ Physiol 295:H1882–H1894

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Curtis SL, Bradley M, Wilde P et al (2012) Results of screening for intracranial aneurysms in patients with coarctation of the aorta. AJNR Am J Neuroradiol 33:1182–1186

    Article  CAS  PubMed  Google Scholar 

  • Day AL (1981) Extracranial-intracranial bypass grafting in the surgical treatment of bacterial aneurysms: report of two cases. Neurosurgery 9:583–588

    Article  CAS  PubMed  Google Scholar 

  • de Barros FM, Castro RN, Lundquist J et al (2011) The role of the pipeline embolization device for the treatment of dissecting intracranial aneurysms. AJNR Am J Neuroradiol 32:2192–2195

    Article  Google Scholar 

  • de Gast AN, Sprengers ME, van Rooij WJ, Lavini C, Sluzewski M, Majoie CB (2007) Long-term 3 T MR angiography follow-up after therapeutic occlusion of the internal carotid artery to detect possible de novo aneurysm formation. AJNR Am J Neuroradiol 28:508–510

    PubMed  Google Scholar 

  • Dell KM (2011) The spectrum of polycystic kidney disease in children. Adv Chronic Kidney Dis 18:339–347

    Article  PubMed  PubMed Central  Google Scholar 

  • Deshmukh VR, Kakarla UK, Figueiredo EG, Zabramski JM, Spetzler RF (2006) Long-term clinical and angiographic follow-up of unclippable wrapped intracranial aneurysms. Neurosurgery 58:434–442

    Article  PubMed  Google Scholar 

  • Drummond IA (2011) Polycystins, focal adhesions and extracellular matrix interactions. Biochim Biophys Acta 1812:1322–1326

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eddleman CS, Surdell D, DiPatri A Jr, Tomita T, Shaibani A (2008) Infectious intracranial aneurysms in the pediatric population: endovascular treatment with Onyx. Childs Nerv Syst 24:909–915

    Article  PubMed  Google Scholar 

  • Ehtuish EF, Mishra A (2008) Multiple visceral aneurysms in antiphospholipid antibody syndrome - an unusual presentation. Br J Radiol 81:e184–e187

    Article  CAS  PubMed  Google Scholar 

  • Fiorella D, Kelly ME, Albuquerque FC, Nelson PK (2009) Curative reconstruction of a giant midbasilar trunk aneurysm with the pipeline embolization device. Neurosurgery 64:212–217

    Article  PubMed  Google Scholar 

  • Fiorella D, Hsu D, Woo HH, Tarr RW, Nelson PK (2010) Very late thrombosis of a pipeline embolization device construct: case report. Neurosurgery 67:onsE313-4

    Google Scholar 

  • Fujitsu K, Ishiwata Y, Gondo G, Fujii S, Feng DD (1994) Wrap-clipping with a Dacron mesh silastic sheet. Technical note. J Neurosurg 80:336–337

    Article  CAS  PubMed  Google Scholar 

  • Futami K, Kimura A, Yamashita J (1992) Intracranial lipoma associated with cerebral saccular aneurysm. J Neurosurg 77:640–642

    Article  CAS  PubMed  Google Scholar 

  • Gao E, Young WL, Pile-Spellman J et al (1997) Cerebral arteriovenous malformation feeding artery aneurysms: a theoretical model of intravascular pressure changes after treatment. Neurosurgery 41:1345–1358

    Article  CAS  PubMed  Google Scholar 

  • Gatscher S, Brew S, Banks T, Simcock C, Sullivan Y, Crockett J (2007) Multislice spiral computed tomography for pediatric intracranial vascular pathophysiologies. J Neurosurg 107:203–208

    PubMed  Google Scholar 

  • Gordillo M, Vega H, Trainer AH et al (2008) The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity. Hum Mol Genet 17:2172–2180

    Article  CAS  PubMed  Google Scholar 

  • Hampton T, Walsh D, Tolias C, Fiorella D (2011) Mural destabilization after aneurysm treatment with a flow-diverting device: a report of two cases. J Neurointerv Surg 3:167–171

    Article  PubMed  Google Scholar 

  • Heiskanen O, Vilkki J (1981) Intracranial arterial aneurysms in children and adolescents. Acta Neurochir (Wien) 59:55–63

    Article  CAS  Google Scholar 

  • Hinek A, Jain S, Taylor G, Nykanen D, Chitayat D (2008) High copper levels and increased elastolysis in a patient with cutis marmorata telangiectasia congenita. Am J Med Genet A 146A:2520–2527

    Article  CAS  PubMed  Google Scholar 

  • Hung PC, Wang HS, Chou ML, Wong AM (2008) Tuberous sclerosis complex with multiple intracranial aneurysms in an infant. Pediatr Neurol 39:365–367

    Article  PubMed  Google Scholar 

  • Osborne-Pellegrin MJ (1978) Some ultrastructural characteristics of the renal artery and abdominal aorta in the rat. J Anat 125:641–652

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hutchinson C, Elbers J, Halliday W et al (2010) Treatment of small vessel primary CNS vasculitis in children: an open-label cohort study. Lancet Neurol 9:1078–1084

    Article  PubMed  Google Scholar 

  • Javadpour M, Khan AD, Jenkinson MD, Foy PM, Nahser HC (2004) Cerebral aneurysm associated with an intracranial tumour: staged endovascular and surgical treatment in two cases. Br J Neurosurg 18:280–284

    Article  CAS  PubMed  Google Scholar 

  • Jones GT, Stehbens WE, Martin BJ (1994) Ultrastructural changes in arteries proximal to short-term experimental carotid-jugular arteriovenous fistulae in rabbits. Int J Exp Pathol 75:225–232

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jost CJ, Gloviczki P, Edwards WD, Stanson AW, Joyce JW, Pairolero PC (2001) Aortic aneurysms in children and young adults with tuberous sclerosis: report of two cases and review of the literature. J Vasc Surg 33:639–642

    Article  CAS  PubMed  Google Scholar 

  • Jurkiewicz E, Jozwiak S (2006) Giant intracranial aneurysm in a 9-year-old boy with tuberous sclerosis. Pediatr Radiol 36:463

    Article  PubMed  Google Scholar 

  • Kamath BM, Spinner NB, Emerick KM et al (2004) Vascular anomalies in Alagille syndrome: a significant cause of morbidity and mortality. Circulation 109:1354–1358

    Article  PubMed  Google Scholar 

  • Khayata MH, Aymard A, Casasco A, Herbreteau D, Woimant F, Merland JJ (1993) Selective endovascular techniques in the treatment of cerebral mycotic aneurysms. Report of three cases. J Neurosurg 78:661–665

    Article  CAS  PubMed  Google Scholar 

  • Kubo S, Nakajima M, Fukuda K et al (2004) A 4-year-old girl with autosomal dominant polycystic kidney disease complicated by a ruptured intracranial aneurysm. Eur J Pediatr 163:675–677

    PubMed  Google Scholar 

  • Kulcsar Z, Ernemann U, Wetzel SG et al (2010) High-profile flow diverter (silk) implantation in the basilar artery: efficacy in the treatment of aneurysms and the role of the perforators. Stroke 41:1690–1696

    Article  PubMed  Google Scholar 

  • Kulcsar Z, Houdart E, Bonafe A et al (2011) Intra-aneurysmal thrombosis as a possible cause of delayed aneurysm rupture after flow-diversion treatment. AJNR Am J Neuroradiol 32:20–25

    Article  CAS  PubMed  Google Scholar 

  • Lanes R, Gunczler P, Lopez E, Esaa S, Villaroel O, Revel-Chion R (2001) Cardiac mass and function, carotid artery intima-media thickness, and lipoprotein levels in growth hormone-deficient adolescents. J Clin Endocrinol Metab 86:1061–1065

    Article  CAS  PubMed  Google Scholar 

  • Lasater EA, Bessler WK, Mead LE et al (2008) Nf1+/− mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathway. Hum Mol Genet 17:2336–2344

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Locksley HB (1966) Natural history of subarachnoid hemorrhage, intracranial aneurysms and arteriovenous malformations. Based on 6368 cases in the cooperative study. J Neurosurg 25:219–239

    Article  CAS  PubMed  Google Scholar 

  • Loeys BL, Schwarze U, Holm T et al (2006) Aneurysm syndromes caused by mutations in the TGF-beta receptor. N Engl J Med 355:788–798

    Article  CAS  PubMed  Google Scholar 

  • Lubicz B, Collignon L, Raphaeli G et al (2010) Flow-diverter stent for the endovascular treatment of intracranial aneurysms: a prospective study in 29 patients with 34 aneurysms. Stroke 41:2247–2253

    Article  PubMed  Google Scholar 

  • Lylyk P, Miranda C, Ceratto R et al (2009) Curative endovascular reconstruction of cerebral aneurysms with the pipeline embolization device: the Buenos Aires experience. Neurosurgery 64:632–643

    Article  PubMed  Google Scholar 

  • Mawad ME, Cekirge S, Ciceri E, Saatci I (2002) Endovascular treatment of giant and large intracranial aneurysms by using a combination of stent placement and liquid polymer injection. J Neurosurg 96:474–482

    Article  PubMed  Google Scholar 

  • McCallum RW, Petrie JR, Dominiczak AF, Connell JM (2002) Growth hormone deficiency and vascular risk. Clin Endocrinol (Oxf) 57:11–24

    Article  CAS  Google Scholar 

  • Medel R, Crowley RW, Hamilton DK, Dumont AS (2009) Endovascular obliteration of an intracranial pseudoaneurysm: the utility of Onyx. J Neurosurg Pediatr 4:445–448

    Article  PubMed  Google Scholar 

  • Meyer WWWS, Lind J (1980) Functional morphology of arteries during fetal and post-natal development. Structure Func Circ 1:95–379

    Article  Google Scholar 

  • Napolioni V, Curatolo P (2008) Genetics and molecular biology of tuberous sclerosis complex. Curr Genomics 9:475–487

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Osborne-Pellegrin MJ (1979) “Spontaneous” lesions of the intima in the rat caudal artery. Principal morphologic characteristic and occurrence as a function of age and sex. Lab Invest 40:668–677

    CAS  PubMed  Google Scholar 

  • Osborne-Pellegrin MJ, Coutard M (1985) Effect of contralateral nephrectomy alone or in association with hypertension on rat renal artery lesions. Atherosclerosis 57:267–280

    Article  CAS  PubMed  Google Scholar 

  • Pamuk AG, Saatci I, Cekirge HS, Aypar U (2005) A contribution to the controversy over dimethyl sulfoxide toxicity: anesthesia monitoring results in patients treated with Onyx embolization for intracranial aneurysms. Neuroradiology 47:380–386

    Article  CAS  PubMed  Google Scholar 

  • Pfeifer M, Verhovec R, Zizek B (1999) Growth hormone (GH) and atherosclerosis: changes in morphology and function of major arteries during GH treatment. Growth Horm IGF Res 9(Suppl A):25–30

    Article  PubMed  Google Scholar 

  • Phillips TJ, Wenderoth JD, Phatouros CC et al (2012) Safety of the pipeline embolization device in treatment of posterior circulation aneurysms. AJNR Am J Neuroradiol 33:1225–1231

    Article  CAS  PubMed  Google Scholar 

  • Piske RL, Kanashiro LH, Paschoal E, Agner C, Lima SS, Aguiar PH (2009) Evaluation of Onyx HD-500 embolic system in the treatment of 84 wide-neck intracranial aneurysms. Neurosurgery 64:E865–E875

    Article  PubMed  Google Scholar 

  • Pistocchi S, Blanc R, Bartolini B, Piotin M (2012) Flow diverters at and beyond the level of the circle of Willis for the treatment of intracranial aneurysms. Stroke 43:1032–1038

    Article  PubMed  Google Scholar 

  • Preul MC, Cendes F, Just N, Mohr G (1998) Intracranial aneurysms and sickle cell anemia: multiplicity and propensity for the vertebrobasilar territory. Neurosurgery 42:971–978

    Article  CAS  PubMed  Google Scholar 

  • Pyeritz RE (2008) A small molecule for a large disease. N Engl J Med 358:2829–2831

    Article  CAS  PubMed  Google Scholar 

  • Radaelli AG, Augsburger L, Cebral JR et al (2008) Reproducibility of haemodynamical simulations in a subject-specific stented aneurysm model–a report on the Virtual Intracranial Stenting Challenge 2007. J Biomech 41:2069–2081

    Article  CAS  PubMed  Google Scholar 

  • Reig AS, Simon S, Mericle RA (2009) Embolization of a giant pediatric, posttraumatic, skull base internal carotid artery aneurysm with a liquid embolic agent. J Neurosurg Pediatr 4:449–452

    Article  PubMed  Google Scholar 

  • Rosser TL, Vezina G, Packer RJ (2005) Cerebrovascular abnormalities in a population of children with neurofibromatosis type 1. Neurology 64:553–555

    Article  PubMed  Google Scholar 

  • Saatci I, Yavuz K, Ozer C, Geyik S, Cekirge HS (2012) Treatment of intracranial aneurysms using the pipeline flow-diverter embolization device: a single-center experience with long-term follow-up results. AJNR Am J Neuroradiol 33:1436–1446

    Article  CAS  PubMed  Google Scholar 

  • Salih MA, Murshid WR, Zahraa JN et al (2006) Congenital and genetic cerebrovascular anomalies as risk factors for stroke in Saudi children. Saudi Med J 27(Suppl 1):S53–S60

    PubMed  Google Scholar 

  • Sanai N, Auguste KI, Lawton MT (2010) Microsurgical management of pediatric intracranial aneurysms. Childs Nerv Syst 26:1319–1327

    Article  PubMed  Google Scholar 

  • Schievink WI, Michels VV, Piepgras DG (1994) Neurovascular manifestations of heritable connective tissue disorders. A review. Stroke 25:889–903

    Article  CAS  PubMed  Google Scholar 

  • Schule B, Oviedo A, Johnston K, Pai S, Francke U (2005) Inactivating mutations in ESCO2 cause SC phocomelia and Roberts syndrome: no phenotype-genotype correlation. Am J Hum Genet 77:1117–1128

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Simon SD, Eskioglu E, Reig A, Mericle RA (2010) Endovascular treatment of side wall aneurysms using a liquid embolic agent: a US single-center prospective trial. Neurosurgery 67:855–860

    Article  PubMed  Google Scholar 

  • Simpson A, Singh SR (1984) Aneurysm of the superior mesenteric artery–a case of Maffucci’s syndrome. Br J Surg 71:241–242

    Article  CAS  PubMed  Google Scholar 

  • Stehbens WE (1999) Evaluation of aneurysm models, particularly of the aorta and cerebral arteries. Exp Mol Pathol 67:1–14

    Article  CAS  PubMed  Google Scholar 

  • Storen EC, Wijdicks EF, Crum BA, Schultz G (2000) Moyamoya-like vasculopathy from cocaine dependency. AJNR Am J Neuroradiol 21:1008–1010

    CAS  PubMed  Google Scholar 

  • Takeshita M, Kagawa M, Izawa M, Kitamura K (1986) Hemorrhagic stroke in infancy, childhood, and adolescence. Surg Neurol 26:496–500

    Article  CAS  PubMed  Google Scholar 

  • Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J (2003) Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 13:1259–1268

    Article  CAS  PubMed  Google Scholar 

  • Tidyman WE, Rauen KA (2009) The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation. Curr Opin Genet Dev 19:230–236

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Touat Z, Ollivier V, Dai J et al (2006) Renewal of mural thrombus releases plasma markers and is involved in aortic abdominal aneurysm evolution. Am J Pathol 168:1022–1030

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Turowski B, Macht S, Kulcsar Z, Hanggi D, Stummer W (2011) Early fatal hemorrhage after endovascular cerebral aneurysm treatment with a flow diverter (SILK-Stent): do we need to rethink our concepts? Neuroradiology 53:37–41

    Article  PubMed  Google Scholar 

  • Vajro P, Lenta S, Socha P et al (2012) Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee. J Pediatr Gastroenterol Nutr 54:700–713

    Article  PubMed  Google Scholar 

  • Wang AC, Gemmete JJ, Keegan CE et al (2011) Spontaneous intracranial hemorrhage and multiple intracranial aneurysms in a patient with Roberts/SC phocomelia syndrome. J Neurosurg Pediatr 8:460–463

    Article  PubMed  Google Scholar 

  • Weber W, Siekmann R, Kis B, Kuehne D (2005) Treatment and follow-up of 22 unruptured wide-necked intracranial aneurysms of the internal carotid artery with Onyx HD 500. AJNR Am J Neuroradiol 26:1909–1915

    PubMed  Google Scholar 

  • Younger DS (2004) Vasculitis of the nervous system. Curr Opinion Neurol 17:317–336

    Article  Google Scholar 

  • Zee CS, Segall HD, McComb JG et al (1986) Intracranial arterial aneurysms in childhood: more recent considerations. J Child Neurol 1:99–114

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sudhakar Vadivelu .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Vadivelu, S., Boyd, J., Abruzzo, T.A. (2015). Intracranial Arterial Aneurysmal Disease in Childhood . In: Lanzer, P. (eds) PanVascular Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37078-6_101

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-37078-6_101

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37077-9

  • Online ISBN: 978-3-642-37078-6

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics