Skip to main content

Meniscus Reconstruction Using a New Collagen Meniscus Implant

  • Reference work entry
  • First Online:
Sports Injuries

Abstract

Meniscal tears are the most common knee injuries, and for years meniscectomy has been considered the gold-standard treatment. As it is now well-known that even partial deficiency of the meniscus could be destructive for the knee joint in the long-term, meniscal substitution has gained popularity. The collagen meniscus implant (CMI) is a resorbable collagen template that supports ingrowth of new tissue and finally regeneration of lost meniscus tissue. The surgical technique is arthroscopic and the post-operative care following CMI resembles that of meniscal suture, with restricted weight-bearing and cautious joint mobilization. Often, complex cases involve a combined procedure such as anterior cruciate ligament (ACL) reconstruction, corrective osteotomy or cartilage treatment, as demonstrated by the high rate of concurrent procedures reported in the literature. The results for both lateral and medial meniscal substitution are generally good in most patients, with evidence of scaffold resorption and in-growth of meniscus-like tissue. The chondroprotective effect of the CMI has not been completely demonstrated, despite encouraging evidence suggesting a reduction of the degenerative changes in the articular cartilage.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 699.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 999.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Baker BE, Peckham AC, Pupparo F et al (1985) Review of meniscal injury and associated sports. Am J Sports Med 13(1):1–4

    Article  CAS  Google Scholar 

  • Bulgheroni P, Murena L, Ratti C et al (2010) Follow-up of collagen meniscus implant patients: clinical, radiological, and magnetic resonance imaging results at 5 years. Knee 17(3):224–229

    Article  Google Scholar 

  • Chatain F, Adeleine P, Chambat P et al (2003) A comparative study of medial versus lateral arthroscopic partial meniscectomy on stable knees: 10-year minimum follow-up. Arthroscopy 19(8):842–849

    Article  CAS  Google Scholar 

  • Ducat A, Sariali E, Lebel B et al (2012) Posterior tibial slope changes after opening- and closing-wedge high tibial osteotomy: a comparative prospective multicenter study. Orthop Traumatol Surg Res 98(1):68–74

    Article  CAS  Google Scholar 

  • Feucht MJ, Mauro CS, Brucker PU et al (2013) The role of the tibial slope in sustaining and treating anterior cruciate ligament injuries. Knee Surg Sports Traumatol Arthrosc 21(1):134–145

    Article  Google Scholar 

  • Genovese E, Angeretti MG, Ronga M et al (2007) Follow-up of collagen meniscus implants by MRI. Radiol Med 112(7):1036–1048

    Article  CAS  Google Scholar 

  • Harston A, Nyland J, Brand E et al (2011) Collagen meniscus implantation: a systematic review including rehabilitation and return to sports activity. Knee Surg Sports Traumatol Arthrosc 20(1):135–146

    Article  Google Scholar 

  • Hirschmann MT, Keller L, Hirschmann A et al (2013) One-year clinical and MR imaging outcome after partial meniscal replacement in stabilized knees using a collagen meniscus implant. Knee Surg Sports Traumatol Arthrosc 21(3):740–747

    Article  CAS  Google Scholar 

  • Koski JA, Ibarra C, Rodeo SA et al (2000) Meniscal injury and repair: clinical status. Orthop Clin North Am 31(3):419–436

    Article  CAS  Google Scholar 

  • Li S-T, Rodkey WG, Yuen D et al (2002) Type I collagen-based template for meniscus regeneration. In: Lewandrowski K-U, Wise DL, Trantolo DJ, Gresser JD, Yaszemski MJ, Altobelli DE (eds) Tissue engineering and biodegradable equivalents. Scientific and clinical applications. Marcel Dekker, New York, pp 237–266

    Google Scholar 

  • Linke RD, Ulmer M, Imhoff AB (2006) Replacement of the meniscus with a collagen implant (CMI)]. Oper Orthop Traumatol 18(5–6):453–62

    Article  Google Scholar 

  • Marcacci M, Zaffagnini S, Giordano G et al (2007) High tibial osteotomy: the Italian experience. Op Tech Orthop 17(1):1–86

    Article  Google Scholar 

  • McBride ID, Reid JG (1988) Biomechanical considerations of the menisci of the knee. Can J Sport Sci 13(4):175–187

    CAS  Google Scholar 

  • McDevitt CA, Webber RJ (1990) The ultrastructure and biochemistry of meniscal cartilage. Clin Orthop Relat Res 1990(252):8–18

    Google Scholar 

  • Monllau JC, Gelber PE, Abat F et al (2011) Outcome after partial medial meniscus substitution with the collagen meniscal implant at a minimum of 10 years’ follow-up. Arthroscopy 27(7):933–943

    Article  Google Scholar 

  • Rodkey WG, Steadman JR, Li ST (1999) A clinical study of collagen meniscus implants to restore the injured meniscus. Clin Orthop Relat Res (367 Suppl):S281–S292

    Google Scholar 

  • Rodkey WG, DeHaven KE, Montgomery WH 3rd et al (2008) Comparison of the collagen meniscus implant with partial meniscectomy. A prospective randomized trial. J Bone Joint Surg Am 90(7):1413–1426

    Article  Google Scholar 

  • Ronga M, Grassi FA, Manelli A et al (2006) Tissue engineering techniques for the treatment of a complex knee injury. Arthroscopy 22(5):576.e1–576.e3

    Article  Google Scholar 

  • Stone KR, Rodkey WG, Webber RJ et al (1990) Future directions. Collagen-based prostheses for meniscal regeneration. Clin Orthop Relat Res 1990(252):129–135

    Google Scholar 

  • Stone KR, Rodkey WG, Webber R et al (1992) Meniscal regeneration with copolymeric collagen scaffolds. In vitro and in vivo studies evaluated clinically, histologically, and biochemically. Am J Sports Med 20(2):104–111

    Article  CAS  Google Scholar 

  • Stone KR, Steadman JR, Rodkey WG et al (1997) Regeneration of meniscal cartilage with use of a collagen scaffold. Analysis of preliminary data. J Bone Joint Surg Am 79(12):1770–1777

    Article  CAS  Google Scholar 

  • Zaffagnini S, Giordano G, Vascellari A et al (2007) Arthroscopic collagen meniscus implant results at 6 to 8 years follow up. Knee Surg Sports Traumatol Arthrosc 15(2):175–183

    Article  Google Scholar 

  • Zaffagnini S, Marcheggiani Muccioli GM, Lopomo N et al (2011a) Prospective long-term outcomes of the medial collagen meniscus implant versus partial medial meniscectomy: a minimum 10-year follow-up study. Am J Sports Med 39(5):977–985

    Article  Google Scholar 

  • Zaffagnini S, Marcheggiani Muccioli GM, Grassi A et al (2011b) Arthroscopic lateral collagen meniscus implant in a professional soccer player. Knee Surg Sports Traumatol Arthrosc 19(10):1740–1743

    Article  Google Scholar 

  • Zaffagnini S, Marcheggiani Muccioli GM, Bulgheroni P et al (2012) Arthroscopic collagen meniscus implantation for partial lateral meniscal defects: a 2-year minimum follow-up study. Am J Sports Med 40(10):2281–2288

    Article  Google Scholar 

  • Zaffagnini S, Bonanzinga T, Grassi A et al (2013) Combined ACL reconstruction and closing-wedge HTO for varus angulated ACL-deficient knees. Knee Surg Sports Traumatol Arthrosc 21(4):934–941

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Maurilio Marcacci .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Marcacci, M., Grassi, A., Muccioli, G.M.M., Nitri, M., Zaffagnini, S. (2015). Meniscus Reconstruction Using a New Collagen Meniscus Implant. In: Doral, M.N., Karlsson, J. (eds) Sports Injuries. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36569-0_76

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-36569-0_76

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-36568-3

  • Online ISBN: 978-3-642-36569-0

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics