Skip to main content
SpringerLink
Log in

Rotator Cuff Repair Augmentation with Platelet-Rich Plasma

  • Reference work entry
  • First Online:
Sports Injuries

  • 232 Accesses

Abstract

Rotator cuff tendon tears are a common source of shoulder pain and combine both traumatic and degenerative issues. Despite multiple surgical techniques to improve bone to tendon healing, recurrent tearing of the rotator cuff is still a significant postoperative issue.

Platelet-rich plasma (PRP) is a fraction of whole blood containing powerful growth factors and cytokines. Basic science and preclinical studies suggest PRP may be useful for tendon repair or regeneration. Rotator cuff studies, however, have produced conflicting results based on PRP formulation, surgical technique, and size of the tendon tear.

This chapter explores and summarizes the available evidence to determine the efficacy of arthroscopic rotator cuff repair in patients with full-thickness rotator cuff tears who were concomitantly treated with PRP.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 699.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 999.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Arnoczky SP (2011) Platelet-rich plasma augmentation of rotator cuff repair: letter. Am J Sports Med 39(6):NP8–NP9

    Article  Google Scholar 

  • Barber FA, Hrnack SA, Snyder SJ et al (2011) Rotator cuff repair healing influenced by platelet-rich plasma construct augmentation. Arthroscopy 27:1029–1035

    Article  Google Scholar 

  • Bergeson AG, Tashjian RZ, Greis PE et al (2012) Effects of platelet-rich fibrin matrix on repair integrity of at-risk rotator cuff tears. Am J Sports Med 40(2):286–293

    Article  Google Scholar 

  • Boileau P, Brassart N, Watkinson DJ et al (2005) Arthroscopic repair of full-thickness tears of the supraspinatus: does the tendon really heal? J Bone Joint Surg Am 87:1229–1240

    Google Scholar 

  • Burkhart SS, Danaceau SM, Pearce CE Jr (2001) Arthroscopic rotator cuff repair: analysis of results by tear size and by repair technique-margin convergence versus direct tendon-to-bone repair. Arthroscopy 17:905–912

    Article  CAS  Google Scholar 

  • Castricini R, Longo UG, M DB et al (2011) Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: a randomized controlled trial. Am J Sports Med 39(2):258–265

    Article  Google Scholar 

  • Cheung EV, Silverio L, Sperling JW (2010) Strategies in biologic augmentation of rotator cuff repair: a review. Clin Orthop Relat Res 468:1476–1484

    Article  Google Scholar 

  • Cole BJ, McCarty LP 3rd, Kang RW et al (2007) Arthroscopic rotator cuff repair: prospective functional outcome and repair integrity at minimum 2-year follow-up. J Should Elb Surg 16(5):579–585

    Article  Google Scholar 

  • Dohan Ehrenfest DM, Bielecki T, Mishra A et al (2012) In search of a consensus terminology in the field of platelet concentrates for surgical use: Platelet-Rich Plasma (PRP), Platelet-Rich Fibrin (PRF), fibrin gel polymerization and leukocytes. Curr Pharm Biotechnol 13(7):1131–1137

    Article  Google Scholar 

  • Eppley BL, Woodell JE, Higgins J (2004) Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 114:1502–1508

    Article  Google Scholar 

  • Everts PA, Knape JT, Weibrich G et al (2006) Platelet-rich plasma and platelet gel: a review. J Extra Corp Technol 38:174–187

    Google Scholar 

  • Galatz LM, Ball CM, Teefey SA et al (2004) The outcome and repair integrity of completely arthroscopically repaired large and massive rotator cuff tears. J Bone Joint Surg Am 86:219–224

    Article  Google Scholar 

  • Galatz LM, Sandell LJ, Rothermich SY et al (2006) Characteristics of the rat supraspinatus tendon during tendon-to-bone healing after acute injury. J Orthop Res 24:541–550

    Article  CAS  Google Scholar 

  • Gumina S, Campagna V, Ferrazza G et al (2012) Use of platelet-leukocyte membrane in arthroscopic repair of large rotator cuff tears: a prospective randomized study. J Bone Joint Surg Am 94(15):1345–1352

    Article  Google Scholar 

  • Hoppe S, Alini M, Benneker LM et al (2013) Tenocytes of chronic rotator cuff tendon tears can be stimulated by platelet-released growth factors. J Should Elb Surg 22(3):340–349

    Article  Google Scholar 

  • Jo CH, Kim JE, Yoon KS et al (2011) Does platelet-rich plasma accelerate recovery after rotator cuff repair? a prospective cohort study. Am J Sports Med 39(10):2082–2090

    Article  Google Scholar 

  • Jo CH, Kim JE, Yoon KS et al (2012) Platelet-rich plasma stimulates cell proliferation and enhances matrix gene expression and synthesis in tenocytes from human rotator cuff tendons with degenerative tears. Am J Sports Med 40(5):1035–1045

    Article  Google Scholar 

  • Kakudo N, Minakata T, Mitsui T et al (2008) Proliferation-promoting effect of platelet-rich plasma on human adipose-derived stem cells and human dermal fibroblasts. Plast Reconstr Surg 122:1352–1360

    Article  CAS  Google Scholar 

  • Lafosse L, Jost B, Reiland Y et al (2007) Structural integrity and clinical outcomes after arthroscopic repair of isolated subscapularis tears. J Bone Joint Surg Am 89(6):1184–1193

    Article  Google Scholar 

  • Lafosse L, Brzoska R, Toussaint B et al (2008) The outcome and structural integrity of arthroscopic rotator cuff repair with use of the double-row suture anchor technique. J Bone Joint Surg Am 90:275–286

    Article  Google Scholar 

  • Levy O, Venkateswaran B, Even T et al (2008) Mid-term clinical and sonographic outcome of arthroscopic repair of the rotator cuff. J Bone Joint Surg (Br) 90:1341–1347

    Article  CAS  Google Scholar 

  • Lichtenberg S, Liem D, Magosch P et al (2006) Influence of tendon healing after arthroscopic rotator cuff repair on clinical outcome using single-row Mason-Allen suture technique: a prospective, MRI controlled study. Knee Surg Sports Traumatol Arthrosc 14(11):1200–1206

    Article  Google Scholar 

  • Mishra A, Harmon K, Woodall J et al (2012) Sports medicine applications of platelet rich plasma. Curr Pharm Biotechnol 13(7):1185–1195

    Article  CAS  Google Scholar 

  • Namazi H (2012) Letter to the editor. Curr Med Res Opin 28(11):1755

    Article  Google Scholar 

  • Randelli P, Arrigoni P, Ragone V et al (2011) Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up. J Should Elb Surg 20:518–528

    Article  Google Scholar 

  • Rodeo SA, Arnoczky SP, Torzilli PA et al (1993) Tendon-healing in a bone tunnel: a biomechanical and histological study in the dog. J Bone Joint Surg Am 75:1795–1803

    Article  CAS  Google Scholar 

  • Rodeo SA, Delos D, Williams RJ et al (2012) The effect of platelet-rich fibrin matrix on rotator cuff tendon healing: a prospective, randomized clinical study. Am J Sports Med 40(6):1234–1241

    Article  Google Scholar 

  • Savitskaya YA, Izaguirre A, Sierra L et al (2011) Effect of angiogenesis-related cytokines on rotator cuff disease: the search for sensitive biomarkers of early tendon degeneration. Clin Med Insights Arthritis Musculoskelet Disord 4:43–53

    Article  CAS  Google Scholar 

  • Sher JS, Uribe JW, Posada A et al (1995) Abnormal findings on magnetic resonance images of asymptomatic shoulders. J Bone Joint Surg Am 77:10–15

    Article  CAS  Google Scholar 

  • Sundman EA, Cole BJ, Fortier LA (2011) Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasma. Am J Sports Med 39(10):2135–2140

    Article  Google Scholar 

  • Weber SC, Kauffman JI, Parise C et al (2013) Platelet-rich fibrin matrix in the management of arthroscopic repair of the rotator cuff: a prospective, randomized, double-blinded study. Am J Sports Med 41(2):263–270

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Surgical Sciences, University of Milano, IRCCS Policlinico San Donato, Milan, Italy

    Pietro Randelli

  2. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, IRCCS Policlinico San Donato, San Donato Milanese, Milano, Italy

    Vincenza Ragone, Silvio Carminati, Marco Pisaniello, Filippo Randelli & Paolo Cabitza

Authors
  1. Pietro Randelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vincenza Ragone
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Silvio Carminati
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Marco Pisaniello
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Filippo Randelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Paolo Cabitza
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pietro Randelli .

Editor information

Editors and Affiliations

  1. Department of Orthopaedics and Traumatology and Department of Sports Medicine, Hacettepe University, Istanbul, Turkey

    Mahmut Nedim Doral

  2. Department of Orthopaedic Surgery, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

    Jon Karlsson

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Randelli, P., Ragone, V., Carminati, S., Pisaniello, M., Randelli, F., Cabitza, P. (2015). Rotator Cuff Repair Augmentation with Platelet-Rich Plasma. In: Doral, M.N., Karlsson, J. (eds) Sports Injuries. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36569-0_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-36569-0_16

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-36568-3

  • Online ISBN: 978-3-642-36569-0

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation