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Part of the book series: Annual Update in Intensive Care and Emergency Medicine ((AUICEM))

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Abstract

In recent years there has been an increasing interest in the use of partial ventilatory support modes not only as weaning techniques but also in the acute phases of respiratory failure. During assisted spontaneous breathing, a variable proportion of the work of breathing is provided by the ventilator, to unload the patient’s respiratory muscles [1]. Multiple ventilator modes are currently available for assisted spontaneous breathing: among these, neurally-adjusted ventilator assist (NAVA) is undergoing extensive clinical evaluation. NAVA is conceptually different from any other mode of ventilation, since the ventilator is not controlled by the ‘pneumatic’ output of respiratory muscles (i. e., a change in airway pressure or flow) but directly by the neural activity of respiratory centers, expressed by the diaphragm electromyogram (EAdi) [2].

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References

  1. Putensen C, Muders T, Varelmann D, Wrigge H (2006) The impact of spontaneous breathing during mechanical ventilation. Curr Opin Crit Care 12:160–165

    Article  PubMed  Google Scholar 

  2. Sinderby C, Navalesi P, Beck J et al (1999) Neural control of mechanical ventilation in respiratory failure. Nat Med 5:1433–1436

    Article  PubMed  CAS  Google Scholar 

  3. Parthasarathy S, Jubran A, Tobin MJ (2000) Assessment of neural inspiratory time in ventilator-supported patients. Am J Respir Crit Care Med 162:546–552

    Article  PubMed  CAS  Google Scholar 

  4. Lourenco RV, Cherniack NS, Malm JR et al (1966) Nervous output from the respiratory centers during obstructed breathing. J Appl Physiol 21:527–533

    PubMed  CAS  Google Scholar 

  5. Beck J, Sinderby C, Lindstrom L et al (1998) Effects of lung volume on diaphragm EMG signal strength during voluntary contractions. J Appl Physiol 85:1123–1134

    PubMed  CAS  Google Scholar 

  6. Beck J, Sinderby C, Lindstrom L et al (1998) Crural diaphragm activation during dynamic contractions at various inspiratory flow rates. J Appl Physiol 85:451–458

    PubMed  CAS  Google Scholar 

  7. Beck J, Gottfried SB, Navalesi P et al (2001) Electrical activity of the diaphragm during pressure support ventilation in acute respiratory failure. Am J Respir Crit Care Med 164:419–424

    Article  PubMed  CAS  Google Scholar 

  8. Sinderby C, Beck J, Spahija J et al (1998) Voluntary activation of the human diaphragm in health and disease. J Appl Physiol 85:2146–2158

    PubMed  CAS  Google Scholar 

  9. Brander L, Sinderby C, Lecomte F et al (2009) Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury. Intensive Care Med 35:1979–1989

    Article  PubMed  Google Scholar 

  10. de Wit M, Miller KB, Green DA et al (2009) Ineffective triggering predicts increased duration of mechanical ventilation. Crit Care Med 37:2740–2745

    Article  PubMed  Google Scholar 

  11. Thille AW, Rodriguez P, Cabello B et al (2006) Patient-ventilator asynchrony during assisted mechanical ventilation. Intensive Care Med 32:1515–1522

    Article  PubMed  Google Scholar 

  12. Beck J, Campoccia F, Allo JC et al (2007) Improved synchrony and respiratory unloading by neurally adjusted ventilatory assist (NAVA) in lung-injured rabbits. Pediatr Res 61:289–294

    Article  PubMed  Google Scholar 

  13. Colombo D, Cammarota G, Bergamaschi V et al (2008) Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute respiratory failure. Intensive Care Med 34:2010–2018

    Article  PubMed  Google Scholar 

  14. Schmidt M, Demoule A, Cracco C et al (2010) Neurally adjusted ventilatory assist increases respiratory variability and complexity in acute respiratory failure. Anesthesiology 112:670–681

    Article  PubMed  Google Scholar 

  15. Terzi N, Pelieu I, Guittet L et al (2010) Neurally adjusted ventilatory assist in patients recovering spontaneous breathing after acute respiratory distress syndrome: physiological evaluation. Crit Care Med 38:1830–1837

    Article  PubMed  Google Scholar 

  16. Spahija J, de Marchie M, Albert M et al (2010) Patient-ventilator interaction during pressure support ventilation and neurally adjusted ventilatory assist. Crit Care Med 38:518–526

    Article  PubMed  Google Scholar 

  17. Patroniti N, Bellani G, Saccavino E et al (2012) Respiratory pattern during neurally adjusted ventilator assist in acute respiratory failure patients. Intensive Care Med 38:230–239

    Article  PubMed  Google Scholar 

  18. Sinderby C, Beck J (2008) Proportional assist ventilation and Neurally Adjusted Ventilatory Assist: better approaches to patient-ventilator synchrony? Clin Chest Med 29:329–342

    Article  PubMed  Google Scholar 

  19. Sinderby C, Beck J, Spahija J et al (2007) Inspiratory muscle unloading by neurally adjusted ventilatory assist during maximal inspiratory efforts in healthy subjects. Chest 131:711–717

    Article  PubMed  Google Scholar 

  20. Wysocki M, Fiamma MN, Straus C et al (2006) Chaotic dynamics of resting ventilatory flow in humans assessed through noise titration. Respir Physiol Neurobiol 153:54–65

    Article  PubMed  Google Scholar 

  21. Suki B, Alencar AM, Sujeer MK et al (1998) Life-support system benefits from noise. Nature 393:127–128

    Article  PubMed  CAS  Google Scholar 

  22. Bien MY, Hseu SS, Yien HW et al (2004) Breathing pattern variability: a weaning predictor in postoperative patients recovering from systemic inflammatory response syndrome. Intensive Care Med 30:241–247

    Article  PubMed  Google Scholar 

  23. Wysocki M, Cracco C, Teixeira A et al (2006) Reduced breathing variability as a predictor of unsuccessful patient separation from mechanical ventilation. Crit Care Med 34:2076–2083

    Article  PubMed  Google Scholar 

  24. Brochard L, Harf A, Lorino H, Lemaire F (1989) Inspiratory pressure support prevents diaphragmatic fatigue during weaning from mechanical ventilation. Am Rev Respir Dis 139:513–521

    Article  PubMed  CAS  Google Scholar 

  25. Tokioka H, Saito S, Kosaka F (1989) Effects of pressure support ventilation on breathing pattern and respiratory work. Intensive Care Med 15:491–494

    Article  PubMed  CAS  Google Scholar 

  26. Barwing J, Linden N, Ambold M, Quintel M, Moerer O (2011) Neurally adjusted ventilatory assist vs. pressure support ventilation in critically ill patients: an observational study. Acta Anaesthesiol Scand 55:1261–1271

    Article  PubMed  CAS  Google Scholar 

  27. Coisel Y, Chanques G, Jung B et al (2010) Neurally adjusted ventilatory assist in critically ill postoperative patients: a crossover randomized study. Anesthesiology 113:925–935

    Article  PubMed  Google Scholar 

  28. Rozé H, Lafrikh A, Perrier V et al (2011) Daily titration of neurally adjusted ventilatory assist using the diaphragm electrical activity. Intensive Care Med 37:1087–1094

    Article  PubMed  Google Scholar 

  29. Piquilloud L, Vignaux L, Bialais E et al (2011) Neurally adjusted ventilatory assist improves patient-ventilator interaction. Intensive Care Med 37:263–271

    Article  PubMed  Google Scholar 

  30. Thille AW, Cabello B, Galia F, Lyazidi A, Brochard L (2008) Reduction of patient-ventilator asynchrony by reducing tidal volume during pressure-support ventilation. Intensive Care Med 34:1477–1486

    Article  PubMed  Google Scholar 

  31. Tuchscherer D, Z’graggen WJ et al (2011) Neurally adjusted ventilatory assist in patients with critical illness-associated polyneuromyopathy. Intensive Care Med 37:1951–1961

    Article  PubMed  Google Scholar 

  32. Nava S, Hill N (2009) Non-invasive ventilation in acute respiratory failure. Lancet 374:250–259

    Article  PubMed  Google Scholar 

  33. Schmidt M, Dres M, Raux M et al (2012) Neurally adjusted ventilatory assist improves patient-ventilator interaction during postextubation prophylactic noninvasive ventilation. Crit Care Med 40:1738–1744

    Article  PubMed  Google Scholar 

  34. Piquilloud L, Tassaux D, Bialais E (2012) Neurally adjusted ventilatory assist (NAVA) improves patient-ventilator interaction during non-invasive ventilation delivered by face mask. Intensive Care Med 38:1624–1631

    Google Scholar 

  35. Bellani G, Patroniti N, Greco M, Foti G, Pesenti A (2008) The use of helmets to deliver non-invasive continuous positive airway pressure in hypoxemic acute respiratory failure. Minerva Anestesiol 74:651–656

    PubMed  CAS  Google Scholar 

  36. Racca F, Appendini L, Gregoretti C et al (2005) Effectiveness of mask and helmet interfaces to deliver noninvasive ventilation in a human model of resistive breathing. J Appl Physiol 99:1262–1271

    Article  PubMed  Google Scholar 

  37. Moerer O, Beck J, Brander L et al (2008) Subject-ventilator synchrony during neural versus pneumatically triggered non-invasive helmet ventilation. Intensive Care Med 34:1615–1623

    Article  PubMed  Google Scholar 

  38. Cammarota G, Olivieri C, Costa R et al (2011) Noninvasive ventilation through a helmet in postextubation hypoxemic patients: physiologic comparison between neutrally adjusted ventilatory assist and pressure support ventilation. Intensive Care Med 37:1943–1950

    Article  PubMed  Google Scholar 

  39. Pesenti A, Zanella A, Patroniti N (2009) Extracorporeal gas exchange. Curr Opin Crit Care 15:52–58

    Article  PubMed  Google Scholar 

  40. Peek GJ, Mugford M, Tiruvoipati R et al (2009) Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet 374:1351–1363

    Article  PubMed  Google Scholar 

  41. Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators (2009) Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) acute respiratory distress syndrome. JAMA 302:1888–1895

    Article  Google Scholar 

  42. Patroniti N, Zangrillo A, Pappalardo F et al (2011) The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks. Intensive Care Med 37:1447–1457

    Article  PubMed  Google Scholar 

  43. Karagiannidis C, Lubnow M, Philipp A et al (2010) Autoregulation of ventilation with neurally adjusted ventilatory assist on extracorporeal lung support. Intensive Care Med 36:2038–2044

    Article  PubMed  Google Scholar 

  44. Mauri T, Bellani G, Foti G et al (2011) Successful use of neurally adjusted ventilatory assist in a patient with extremely low respiratory system compliance undergoing ECMO. Intensive Care Med 37:166–167

    Article  PubMed  Google Scholar 

  45. Rozé H, Ouattara A (2012) Use of neural trigger during neurally adjusted ventilatory assist in a patient with a large broncho-pleural fistula and air leakage. Intensive Care Med 38:922–923

    Article  PubMed  Google Scholar 

  46. Brander L, Leong-Poi H, Beck J et al (2009) Titration and implementation of neurally adjusted ventilatory assist in critically ill patients. Chest 135:695–703

    Article  PubMed  Google Scholar 

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Patroniti, N., Grasselli, G., Bellani, G. (2013). NAVA: Applications and Limitations. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2013. Annual Update in Intensive Care and Emergency Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35109-9_48

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  • DOI: https://doi.org/10.1007/978-3-642-35109-9_48

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