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Anatomical Aspects of the Neurovascular Bundle in Prostate Surgery

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Abstract

Over recent years, widespread prostate-specific antigen screening has resulted in a downwards stage migration of prostate cancer in developed nations, with most patients being diagnosed nowadays at a younger age with early organ-confined disease [1–3]. Radical prostatectomy has a proven survival benefit over conservative treatment [4, 5], and thus is the gold standard for the management of clinically localized prostate cancer. Hence, with more patients undergoing surgery, minimizing functional loss is of utmost importance. However, despite recent advances in surgical technique and technologies, return of erectile function sufficient for sexual intercourse at 1 year after surgery varies from 15 to 87 %, respectively, in contemporary series of radical prostatectomy [6–8]. For younger men, postprostatectomy erectile dysfunction (PPED) significantly affects their sense of masculinity and their daily interactions with women [9, 10]. Patient age, clinical and pathological stage of cancer, preoperative potency status, and aggressiveness of nerve-sparing are the most significant factors for recovery of potency after surgery [11–13]. Surgeon experience and surgical volume, penile ischemia and subsequent fibrosis, and veno-occlusive disease are also important for successful return of sexual function following surgery [14, 15].

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References

  1. Schröder FH, Hugosson J, Roobol MJ et al (2009) Screening and prostate-cancer mortality in a randomized European study. N Engl J Med 360:1320–1328

    Article  PubMed  Google Scholar 

  2. Jemal A, Siegel R, Ward E et al (2009) Cancer statistics, 2009. CA Cancer J Clin 59:225–249

    Article  PubMed  Google Scholar 

  3. Quinn M, Babb P (2002) Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part 1: international comparisons. BJU Int 90:162–173

    Article  PubMed  CAS  Google Scholar 

  4. Bill-Axelson A, Holmberg L, Ruutu M et al (2005) Radical prostatectomy versus watchful waiting in early prostate cancer. N Engl J Med 352(19):1977–1984

    Article  PubMed  CAS  Google Scholar 

  5. Tewari A, Johnsson CC, Devine G, Crawford ED, Gamito EJ, Demers R, Menon M (2004) Long-term survival probability in men with clinically localized prostate cancer: a case–control, propensity modeling study stratified by race, age, treatment and co-­morbidities. J Urol 171:1513–1519

    Article  PubMed  Google Scholar 

  6. Zippe C, Nandipati K, Agarwal A, Raina R (2006) Sexual dysfunction after pelvic surgery. Int J Impot Res 18:1–18

    Article  PubMed  CAS  Google Scholar 

  7. Berryhill R Jr, Jhaveri J, Yadav R et al (2008) Robotic prostatectomy: a review of outcomes compared with laparoscopic and open approaches. Urology 72:15–23

    Article  PubMed  Google Scholar 

  8. Ficarra V, Novara G, Artibani W et al (2009) Retropubic, laparoscopic and robot-assisted radical prostatectomy: a systematic review and cumulative analysis of comparative studies. Eur Urol 55:1037–1063

    Article  PubMed  Google Scholar 

  9. Penson DF, Feng Z, Kuniyuki A, McClerran D, Albertsen PC, Deapen D et al (2003) General quality of life 2 years following treatment for prostate cancer: what influences outcomes? Results from the prostate cancer outcomes study. J Clin Oncol 21:1147–1154

    Article  PubMed  Google Scholar 

  10. Kirschner-Hermanns R, Jakse G (2002) Quality of life following radical prostatectomy. Crit Rev Oncol Hematol 43:141–151

    Article  PubMed  Google Scholar 

  11. Quinlan DM, Epstein JI, Carter BS, Walsh PC (1991) Sexual function following radical prostatectomy: influence of preservation of neurovascular bundles. J Urol 145:998–1002

    PubMed  CAS  Google Scholar 

  12. Rabbani F, Stapleton AM, Kattan MW, Wheeler TM, Scardino PT (2000) Factors predicting recovery of erections after radical prostatectomy. J Urol 164(6):1929–1934

    Article  PubMed  CAS  Google Scholar 

  13. Dubbelman YD, Dohle GR, Schroder FH (2006) Sexual function before and after radical retropubic prostatectomy: a systematic review of prognostic indicators for a successful outcome. Eur Urol 50:711–720

    Article  PubMed  Google Scholar 

  14. McCullough AR (2008) Rehabilitation of erectile function following radical prostatectomy. Asian J Androl 10(1):61–74

    Article  PubMed  Google Scholar 

  15. Bianco F, Kattan M, Eastham J, Scardino P, Mulhall JP (2004) Surgeon and surgical volume as predictors of erectile function outcomes following radical prostatectomy. J Sex Med 1:33

    Google Scholar 

  16. Kim ED, Blackburn D, McVary KT (1994) Post-radical prostatectomy penile blood flow: assessment with color Doppler ultrasound. J Urol 152:2276–2279

    PubMed  CAS  Google Scholar 

  17. Mulhall JP, Slovick R, Hotaling J et al (2002) Erectile dysfunction after radical prostatectomy: haemodynamic profiles and their correlation with the recovery of erectile function. J Urol 167:1371–1375

    Article  PubMed  Google Scholar 

  18. Kawanishi Y, Lee KS, Kimura K, Kojima K, Yamamoto A, Numata A (2001) Effect of radical retropubic prostatectomy on erectile function, evaluated before and after surgery using color Doppler ultrasonography and nocturnal penile tumescence monitoring. BJU Int 88:244–247

    Article  PubMed  CAS  Google Scholar 

  19. Walz J, Graefen M, Huland H (2007) Basic principles of anatomy for optimal surgical management of prostate cancer. World J Urol 25:31–38

    Article  PubMed  Google Scholar 

  20. Walsh PC, Donker PJ (1982) Impotence following radical prostatectomy: insight into etiology and prevention. J Urol 128:492–497

    PubMed  CAS  Google Scholar 

  21. Lepor H, Gregerman M, Crosby R, Mostofi FK, Walsh PC (1985) Precise localization of the autonomic nerves from the pelvic plexus to the corpora cavernosa: a detailed anatomical study of the adult male ­pelvis. J Urol 133:207–12

    PubMed  CAS  Google Scholar 

  22. Walsh PC (1998) Anatomic radical prostatectomy: evolution of surgical technique. J Urol 160:2418–2424

    Article  PubMed  CAS  Google Scholar 

  23. Costello AJ, Brooks M, Cole OJ (2004) Anatomical studies of the neurovascular bundle and cavernosal nerves. BJU Int 94:1071–1076

    Article  PubMed  Google Scholar 

  24. Takenaka A, Murakami G, Matsubara A et al (2005) Variation in course of cavernous nerve with special reference to details of topographic relationships near prostatic apex: histologic study using male cadavers. Urology 65:136–142

    Article  PubMed  Google Scholar 

  25. Kiyoshima K, Yokomizo A, Yoshida T et al (2004) Anatomic features of periprostatic tissue and its surroundings: a histological analysis of 79 radical retropubic prostatectomy specimens. Jpn J Clin Oncol 34:463–468

    Article  PubMed  Google Scholar 

  26. Eichelberg C, Erbersdobler A, Michl U, Schlomm T, Salomon G, Graefen M et al (2007) Nerve distribution along the prostatic capsule. Eur Urol 51(1):105–111

    Article  PubMed  Google Scholar 

  27. Tewari A, Takenaka A, Mtui E, Horninger W, Peschel R, Bartsch G, Vaughan ED (2006) The proximal neurovascular plate and the tri-zonal neural architecture around the prostate gland: importance in the athermal robotic technique of nerve-sparing prostatectomy. BJU Int 98:318–323

    Google Scholar 

  28. Tewari A, Tan GY, Dorsey PJ Jr, Yadav R, Ramanathan R, Patel N, Takenaka A (2008) Optimizing erectogenic outcomes during athermal robotic prostatectomy: a risk-stratified tri-zonal approach. Urol Times Clinical Edition 3:s4–s12

    Google Scholar 

  29. Tewari A, Peabody JO, Fischer M et al (2003) An operative and anatomic study to help in nerve-sparing during laparoscopic and robotic radical prostatectomy. Eur Urol 43:444–454

    Article  PubMed  Google Scholar 

  30. Chuang MS, O-Connor RC, Laven BA, Orvieto MA, Brendler CB (2005) Early release of the neurovascular bundles and optical loupe magnification lead to improved and earlier return of potency following radical retropubic prostatectomy. J Urol 173:537–539

    Article  PubMed  Google Scholar 

  31. Magera JS, Inman BA, Slezak JM, Bagniewski SM, Sebo TJ, Myers RP (2008) Increased optical magnification from 2.5x to 4.3x with technical modification lowers the positive margin rate in open radical retropubic prostatectomy. J Urol 179:130–135

    Article  PubMed  Google Scholar 

  32. Klotz L, Herschorn S (1998) Early experience with intraoperative cavernous nerve stimulation with penile tumescence monitoring to improve nerve sparing during radical prostatectomy. Urology 52:537–542

    Article  PubMed  CAS  Google Scholar 

  33. Walsh PC, Marschke P, Catalona WJ, Lepor H, Martin S, Myers RP et al (2001) Efficacy of first-generation CaverMap to verify location and function of ­cavernous nerves during radical prostatectomy: a multi-­institutional evaluation by experienced surgeons. Urology 57:491–494

    Article  PubMed  CAS  Google Scholar 

  34. Holzbeierlein J, Peterson M, Smith JA Jr (2001) Variability of results of cavernous nerve stimulation during radical prostatectomy. J Urol 165:108–110

    Article  PubMed  CAS  Google Scholar 

  35. Ukimura O, Gill IS, Desai MM et al (2004) Real-time transrectal ultrasonography during laparoscopic radical prostatectomy. J Urol 172:112–118

    Article  PubMed  Google Scholar 

  36. Huang D, Swanson EA, Lin CP et al (1991) Optical coherence tomography. Science 254:1178–1181

    Article  PubMed  CAS  Google Scholar 

  37. Mourant JR, Bigio IJ, Boyer J et al (1995) Spectroscopic diagnosis of bladder cancer with elastic light scattering. Lasers Surg Med 17:350–357

    Article  PubMed  CAS  Google Scholar 

  38. Crow P, Molckovsky A, Stone J et al (2005) Assessment of fibreoptic near-infrared Raman spectroscopy for diagnosis of bladder and prostate cancer. Urology 65:1126–1130

    Article  PubMed  CAS  Google Scholar 

  39. Davila HH, Mamcarz M, Nadelhaft I et al (2007) Visualization of the neurovascular bundles and major pelvic ganglion with fluorescent tracers after penile injection in the rat. BJU Int 101:1048–1051

    Article  PubMed  Google Scholar 

  40. Yadav R, Mukherjee S, Hermen M et al (2009) Multiphoton microscopy of prostate and periprostatic neural tissue: a promising imaging technique for improving nerve-sparing prostatectomy. J Endourol 23:861–867

    Article  PubMed  Google Scholar 

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Correspondence to Ashutosh K. Tewari .

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Sooriakumaran, P., Tan, G.Y., Grover, S., Takenaka, A., Tewari, A.K. (2013). Anatomical Aspects of the Neurovascular Bundle in Prostate Surgery. In: John, H., Wiklund, P. (eds) Robotic Urology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33215-9_17

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  • DOI: https://doi.org/10.1007/978-3-642-33215-9_17

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