Skip to main content
SpringerLink
Log in

Parkinson-Syndrom, Chorea Huntington

  • Chapter
Funktionelle MRT in Psychiatrie und Neurologie

  • 10k Accesses

Zusammenfassung

Das Parkinson-Syndrom und die Chorea Huntington gehören zu den neurodegenerativen Bewegungsstörungen, die – ebenso wie die Dystonien (► Kap. 33) – traditionell den Basalganglienerkrankungen zugeordnet werden. Funktionelle magnetresonanztomographische Verfahren leisten einen wichtigen Beitrag zum Verständnis sowohl der motorischen, aber auch der nichtmotorischen Symptome (Kognition und psychische Auffälligkeiten) dieser Erkrankungsbilder. Insbesondere die nichtmotorischen Symptome als auch genetische Aspekte sind zunehmend in den Interessenfokus gerückt, was sich auch in den nachfolgend vorgestellten funktionellen Bildgebungsstudien widerspiegelt. Hierbei sind Studien in einem sehr frühen bzw. asymptomatischen Stadium von besonderem Interesse. Auch methodisch findet sich eine Erweiterung um interessante Bildgebungsstudien zur funktionellen Konnektivität.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

Literatur

  • Anders S, Sack B, Pohl A et al. (2012) Compensatory premotor activity during affective face processing in subclinical carriers of a single mutant Parkin allele. Brain 135: 1128–1140

    Article  PubMed  Google Scholar 

  • Baudrexel S, Witte T, Seifried C et al. (2011) Resting state fMRI reveals increased subthalamic nucleus-motor cortex connectivity in Parkinson’s disease. Neuroimage 55: 1728–1738

    Article  PubMed  Google Scholar 

  • Bartrés-Faz D, Martí MJ, Junqué C et al. (2007) Increased cerebral activity in Parkinson’s disease patients carrying the DRD2 TaqIA A1 allele during a demanding motor task: a compensatory mechanism? Genes Brain Behav 6: 588–592

    Article  PubMed  Google Scholar 

  • Bekris LM, Mata IF, Zabetian CP (2010) The genetics of Parkinson disease. J Geriatr Psychiatry Neurol 23: 228–242

    Article  PubMed  Google Scholar 

  • Bloem BR, Grimbergen YA, Cramer M, Valkenburg VV (2000) »Stops walking when talking« does not predict falls in Parkinson’s disease. Ann Neurol 48: 268

    Article  CAS  PubMed  Google Scholar 

  • Bohanna I, Georgiou-Karistianis N, Hannan AJ, Egan GF (2008) Magnetic resonance imaging as an approach towards identifying neuropathological biomarkers for Huntington’s disease. Brain Res Rev 58: 209–225

    Article  CAS  PubMed  Google Scholar 

  • Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K (2004) Stages in the development of Parkinson’s disease-related pathology. Cell Tissue Res 318: 121–134

    Article  PubMed  Google Scholar 

  • Braak H, Del Tredici K (2008) Invited Article: Nervous system pathology in sporadic Parkinson disease. Neurology 70: 1916–1925

    Article  PubMed  Google Scholar 

  • Buhmann C, Glauche V, Sturenburg HJ et al. (2003) Pharmacologically modulated fMRI – cortical responsiveness to levodopa in drugnaive hemiparkinsonian patients. Brain 126: 451–461

    Article  CAS  PubMed  Google Scholar 

  • Buhmann C, Binkofski F, Klein C, Buchel C, van Eimeren T, Erdmann C, Hedrich K, Kasten M, Hagenah J, Deuschl G, Pramstaller PP, Siebner HR (2005) Motor reorganization in asymptomatic carriers of a single mutant Parkin allele: a human model for presymptomatic parkinsonism. Brain 128: 2281–2290

    Article  CAS  PubMed  Google Scholar 

  • Cardoso EF, Maia FM, Fregni F et al. (2009) Depression in Parkinson’s disease: convergence from voxel-based morphometry and functional magnetic resonance imaging in the limbic thalamus. Neuroimage 47: 467–472

    Article  PubMed  Google Scholar 

  • Ceballos-Baumann AO (2003) Functional imaging in Parkinson’s disease: activation studies with PET, fMRI and SPECT. J Neurol 250 Suppl 1: I15–123

    Article  Google Scholar 

  • Cerasa A, Hagberg GE, Peppe A et al. (2006) Functional changes in the activity of cerebellum and frontostriatal regions during externally and internally timed movement in Parkinson’s disease. Brain Res Bull 71: 259–269

    Article  PubMed  Google Scholar 

  • Clark VP, Lai S, Deckel AW (2002) Altered functional MRI responses in Huntington’s disease. Neuroreport 13: 703–706

    Article  PubMed  Google Scholar 

  • Clark US, Neargarder S, Cronin-Golomb A (2008) Specific impairments in the recognition of emotional facial expressions in Parkinson’s disease. Neuropsychologia 46: 2300–2309

    Article  PubMed  Google Scholar 

  • DeLong MR (1990) Primate models of movement disorders of basal ganglia origin. Trends Neurosci 13: 281–285

    Article  CAS  PubMed  Google Scholar 

  • Dierks T, Linden DE, Hertel A et al. (1999) Multimodal imaging of residual function and compensatory resource allocation in cortical atrophy: a case study of parietal lobe function in a patient with Huntington’s disease. Psychiatry Res 90: 67–75

    CAS  PubMed  Google Scholar 

  • Farrer MJ (2006) Genetics of Parkinson disease: paradigm shifts and future prospects. Nat Rev Genet 7: 306–318

    Article  CAS  PubMed  Google Scholar 

  • Frosini D, Pesaresi I, Cosottini M et al. (2010) Parkinson’s disease and pathological gambling: results from a functional MRI study. Mov Disord 25: 2449–2453

    Article  PubMed  Google Scholar 

  • Gavazzi C, Nave RD, Petralli R et al. (2007) Combining functional and structural brain magnetic resonance imaging in Huntington disease. J Comput Assist Tomogr 31: 574–580

    Article  PubMed  Google Scholar 

  • Georgiou-Karistianis N, Sritharan A, Farrow M et al. (2007) Increased cortical recruitment in Huntington’s disease using a Simon task. Neuropsychologia 45: 1791–1800

    Article  PubMed  Google Scholar 

  • Glickstein M, Stein J (1991) Paradoxical movement in Parkinson’s disease. Trends Neurosci 14: 480–482

    Article  CAS  PubMed  Google Scholar 

  • Haslinger B, Erhard P, Kampfe N et al. (2001) Event-related functional magnetic resonance imaging in Parkinson’s disease before and after levodopa. Brain 124: 558–570

    Article  CAS  PubMed  Google Scholar 

  • Helmich RC, Derikx LC, Bakker M et al. (2010) Spatial remapping of cortico-striatal connectivity in Parkinson’s disease. Cereb Cortex 20: 1175–1186

    Article  PubMed  Google Scholar 

  • Hennenlotter A, Schroeder U, Erhard P et al. (2004) Neural correlates associated with impaired disgust processing in pre-symptomatic Huntington’s disease. Brain 127: 1446–1453

    Article  CAS  PubMed  Google Scholar 

  • Hilker R, Klein C, Ghaemi M, Kis B, Strotmann T, Ozelius LJ et al. (2001) Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene. Ann Neurol 49: 367–376

    Article  CAS  PubMed  Google Scholar 

  • Hughes LE, Barker RA, Owen AM, Rowe JB (2010) Parkinson’s disease and healthy aging: independent and interacting effects on action selection. Hum Brain Mapp 31: 1886–1899

    Article  PubMed  Google Scholar 

  • Kehagia AA, Barker RA, Robbins TW (2010) Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson’s disease. Lancet Neurol 9: 1200–1213

    Article  PubMed  Google Scholar 

  • Kim JS, Reading SA, Brashers-Krug T et al. (2004) Functional MRI study of a serial reaction time task in Huntington’s disease. Psychiatry Res 131: 23–30

    Article  PubMed  Google Scholar 

  • Klein C, Schlossmacher MG (2006) The genetics of Parkinson disease: Implications for neurological care. Nat Clin Pract Neurol 2: 136–146

    Article  CAS  PubMed  Google Scholar 

  • Kloppel S, Draganski B, Siebner HR et al. (2009) Functional compensation of motor function in pre-symptomatic Huntington’s disease. Brain 132: 1624–1632

    Article  PubMed  Google Scholar 

  • Kloppel S, Stonnington CM, Petrovic P et al. (2010) Irritability in preclinical Huntington’s disease. Neuropsychologia 48: 549–557

    Article  PubMed  Google Scholar 

  • Kwak Y, Peltier S, Bohnen NI et al. (2010) Altered resting state corticostriatal connectivity in mild to moderate stage Parkinson’s disease. Front Syst Neurosci 4: 143

    Article  CAS  PubMed  Google Scholar 

  • Lang AE (2003) Subthalamic stimulation for Parkinson’s disease – living better electrically? N Engl J Med 349: 1888–1891

    Article  PubMed  Google Scholar 

  • Lewis SJ, Cools R, Robbins TW et al. (2003) Using executive heterogeneity to explore the nature of working memory deficits in Parkinson’s disease. Neuropsychologia 41: 645–654

    Article  PubMed  Google Scholar 

  • Mattay VS, Tessitore A, Callicott JH et al. (2002) Dopaminergic modulation of cortical function in patients with Parkinson’s disease. Ann Neurol 51: 156–164

    Article  CAS  PubMed  Google Scholar 

  • Meppelink AM, de Jong BM, Renken R et al. (2009) Impaired visual processing preceding image recognition in Parkinson’s disease patients with visual hallucinations. Brain 132: 2980–2993

    Article  PubMed  Google Scholar 

  • Moessnang C, Frank G, Bogdahn U et al. (2011) Altered activation patterns within the olfactory network in Parkinson’s disease. Cereb Cortex 21: 1246–1253

    Article  PubMed  Google Scholar 

  • Monchi O, Petrides M, Doyon J et al. (2004) Neural bases of set-shifting deficits in Parkinson’s disease. J Neurosci 24: 702–710

    Article  CAS  PubMed  Google Scholar 

  • Palmer SJ, Li J, Wang ZJ, McKeown MJ (2010) Joint amplitude and connectivity compensatory mechanisms in Parkinson’s disease. Neuroscience 166: 1110–1118

    Article  CAS  PubMed  Google Scholar 

  • Pankratz N, Nichols WC, Uniacke SK et al. (2003) Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families. Hum Mol Genet 12: 2599–2608

    Article  CAS  PubMed  Google Scholar 

  • Paulsen JS, Zimbelman JL, Hinton SC et al. (2004) fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington’s Disease. AJNR Am J Neuroradiol 25: 1715–1721

    PubMed  Google Scholar 

  • Pinto S, Mancini L, Jahanshahi M et al. (2011) Functional magnetic resonance imaging exploration of combined hand and speech movements in Parkinson’s disease. Mov Disord 26: 2212–2219

    Article  PubMed  Google Scholar 

  • Ramirez-Ruiz B, Marti MJ, Tolosa E et al. C (2008) Brain response to complex visual stimuli in Parkinson’s patients with hallucinations: a functional magnetic resonance imaging study. Mov Disord 23: 2335–2343

    Article  PubMed  Google Scholar 

  • Rao H, Mamikonyan E, Detre JA et al. (2010) Decreased ventral striatal activity with impulse control disorders in Parkinson’s disease. Mov Disord 25: 1660–1669

    Article  PubMed  Google Scholar 

  • Reading SA, Dziorny AC, Peroutka LA et al. (2004) Functional brain changes in presymptomatic Huntington’s disease. Ann Neurol 55: 879–883

    Article  PubMed  Google Scholar 

  • Rowe J, Stephan KE, Friston K et al. (2002) Attention to action in Parkinson’s disease: impaired effective connectivity among frontal cortical regions. Brain 125: 276–289

    Article  PubMed  Google Scholar 

  • Rupp J, Dzemidzic M, Blekher T et al. (2011) Abnormal error-related antisaccade activation in premanifest and early manifest Huntington disease. Neuropsychology 25: 306–318

    Article  PubMed  Google Scholar 

  • Sabatini U, Boulanouar K, Fabre N et al. (2000) Cortical motor reorganization in akinetic patients with Parkinson’s disease: a functional MRI study. Brain 123 (Pt 2): 394–403

    Article  PubMed  Google Scholar 

  • Saft C, Schuttke A, Beste C et al. (2008) fMRI reveals altered auditory processing in manifest and premanifest Huntington’s disease. Neuropsychologia 46: 1279–1289

    Article  PubMed  Google Scholar 

  • Schonberg T, O’Doherty JP, Joel D et al. (2010) Selective impairment of prediction error signaling in human dorsolateral but not ventral striatum in Parkinson’s disease patients: evidence from a modelbased fMRI study. Neuroimage 49: 772–781

    Article  PubMed  Google Scholar 

  • Snijders AH, van de Warrenburg BP, Giladi N, Bloem BR (2007) Neurological gait disorders in elderly people: clinical approach and classification. Lancet Neurol 6: 63–64

    Article  PubMed  Google Scholar 

  • Snijders AH, Leunissen I, Bakker M et al. (2010) Gait-related cerebral alterations in patients with Parkinson’s disease with freezing of gait. Brain 134: 59–72

    Article  PubMed  Google Scholar 

  • Sprengelmeyer R, Young AW, Mahn K et al. (2003) Facial expression recognition in people with medicated and unmedicated Parkinson’s disease. Neuropsychologia 41: 1047–1057

    Article  CAS  PubMed  Google Scholar 

  • Tessitore A, Hariri AR, Fera F et al. (2002) Dopamine modulates the response of the human amygdala: a study in Parkinson’s disease. J Neurosci 22: 9099–9103

    CAS  PubMed  Google Scholar 

  • Thiruvady DR, Georgiou-Karistianis N, Egan GF et al. (2007) Functional connectivity of the prefrontal cortex in Huntington’s disease. J Neurol Neurosurg Psychiatry 78: 127–133

    Article  CAS  PubMed  Google Scholar 

  • van Eimeren T, Ballanger B, Pellecchia G et al. (2009a) Dopamine agonists diminish value sensitivity of the orbitofrontal cortex: a trigger for pathological gambling in Parkinson’s disease? Neuropsychopharmacology 34: 2758–2766

    Article  CAS  Google Scholar 

  • van Eimeren T, Monchi O, Ballanger B, Strafella AP (2009b) Dysfunction of the default mode network in Parkinson disease: a functional magnetic resonance imaging study. Arch Neurol 66: 877–883

    Article  Google Scholar 

  • van Eimeren T, Binkofski F, Buhmann C, Hagenah J, Strafella AP, Pramstaller PP et al. (2010) Imaging movement-related activity in medicated Parkin-associated and sporadic Parkinson’s disease. Parkinsonism Relat Disord 16: 384-387

    Article  PubMed  Google Scholar 

  • van Nuenen BF, Weiss MM, Bloem BR et al. (2009) Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype. Neurology 72: 1041–1047

    Article  PubMed  Google Scholar 

  • Voermans NC, Petersson KM, Daudey L et al. (2004) Interaction between the human hippocampus and the caudate nucleus during route recognition. Neuron 43: 427–435

    Article  CAS  PubMed  Google Scholar 

  • Werheid K, Zysset S, Muller A, Reuter M, von Cramon DY (2003) Rule learning in a serial reaction time task: an fMRI study on patients with early Parkinson’s disease. Brain Res Cogn Brain Res 16: 273–284

    Article  PubMed  Google Scholar 

  • Westermann B, Wattendorf E, Schwerdtfeger U et al. (2008) Functional imaging of the cerebral olfactory system in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry 79: 19–24

    Article  CAS  PubMed  Google Scholar 

  • Wolf RC, Vasic N, Schonfeldt-Lecuona C et al. (2007) Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington’s disease: evidence from event-related fMRI. Brain 130: 2845–2857

    Article  PubMed  Google Scholar 

  • Wolf RC, Sambataro F, Vasic N et al. (2008a) Aberrant connectivity of lateral prefrontal networks in presymptomatic Huntington’s disease. Exp Neurol 213: 137–144

    Article  CAS  Google Scholar 

  • Wolf RC, Sambataro F, Vasic N et al. (2008b) Altered frontostriatal coupling in pre-manifest Huntington’s disease: effects of increasing cognitive load. Eur J Neurol 15: 1180–1190

    Article  CAS  Google Scholar 

  • Wolf RC, Vasic N, Schonfeldt-Lecuona C et al. (2008c) [Functional imaging of cognitive processes in Huntington’s disease and its presymptomatic mutation carriers]. Nervenarzt 79: 408–420

    Article  CAS  Google Scholar 

  • Wu T, Long X, Zang Y et al. (2009) Regional homogeneity changes in patients with Parkinson’s disease. Hum Brain Mapp 30: 1502–1510

    Article  PubMed  Google Scholar 

  • Wu T, Long X, Wang L et al. (2010) Functional connectivity of cortical motor areas in the resting state in Parkinson’s disease. Hum Brain Mapp 32: 1443–1457

    Article  PubMed  Google Scholar 

  • Yu H, Sternad D, Corcos DM, Vaillancourt DE (2007) Role of hyperactive cerebellum and motor cortex in Parkinson’s disease. Neuroimage 35: 222–233

    Article  PubMed  Google Scholar 

  • Zimbelman JL, Paulsen JS, Mikos A et al. (2007) fMRI detection of early neural dysfunction in preclinical Huntington’s disease. J Int Neuropsychol Soc 13: 758–769

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurologische Klinik, Universitätsklinikum Aachen, Pauwelsstraße 30, 52074, Aachen

    Prof. Dr. Kathrin Reetz & Prof. Dr. Ferdinand C. Binkofski

  2. Institut für Neurowissenschaften und Medizin (INM-4), Forschungszentrum Jülich, 52425, Jülich

    Prof. Dr. Kathrin Reetz & Prof. Dr. Ferdinand C. Binkofski

  3. Klinik und Poliklinik für Neurologie, Klinikum der Universität zu Köln, Kerpener Straße 62, 50937, Köln

    Dr. Carsten Eggers

Authors
  1. Prof. Dr. Kathrin Reetz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prof. Dr. Ferdinand C. Binkofski
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dr. Carsten Eggers
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Universitätsklinikum Aachen, Aachen

    Frank Schneider

  2. Forschungszentrum Jülich, Jülich

    Gereon R. Fink

  3. Uniklinik Köln, Köln

    Gereon R. Fink

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Reetz, K., Binkofski, F., Eggers, C. (2013). Parkinson-Syndrom, Chorea Huntington. In: Schneider, F., Fink, G.R. (eds) Funktionelle MRT in Psychiatrie und Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29800-4_34

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-29800-4_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-29799-1

  • Online ISBN: 978-3-642-29800-4

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation