Synonyms
Arborols; Cascade molecules; Dendritic polymers; Dendron
Definition
Dendrimers are synthetically manufactured, three-dimensional macromolecules built up from a monomer, with new branches added in steps until a treelike structure is created. Dendrimers are technically polymers and are being investigated for possible uses in nanotechnology and other fields.
Introduction and Historical Background
The application of nanotechnology in medicine and pharmaceuticals is a rapidly advancing field that is swiftly gaining recognition as an autonomous area of research called “nanomedicine.” Critical needs in this field, however, are biocompatible and bioactive materials for in vivo and in vitro diagnostics as well as therapy including targeted delivery and regenerative medicine. Therefore, extensive attention has been given to the design and development of new macromolecular systems. Among the various polymeric architectures, dendritic (“treelike”) polymers have experienced an exponential...
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References
Buhleier E, Wehner W, Vögtle F (1978) “Cascade”- and “Nonskid-Chain-like” syntheses of molecular cavity topologies. Synthesis 2:155–158
Tomalia DA et al (1985) A new class of polymers: starburst-dendritic macromolecules. Poly Jr 17:117–132
Newkome GR, Moorefield CN, Vögtle F (2001) Dendrimers and dendrons: concepts, syntheses, applications. Wiley-VCH, Weinheim
Hawker CJ, Fréchet JMJ (1990) Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules. J Am Chem Soc 112:7638–7647
For detailed information: Scifinder (2012)
Cheng Y, Tomalia DA (2012) Dendrimer-based drug delivery systems: from theory to practice. Wiley-VCH, Hoboken
Matsumura Y, Maeda HA (1986) New concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 46:6387–6392
Neerman MF et al (2004) Reduction of drug toxicity using dendrimers based on melamine. Mol Pharm 1:390–393
Agarwal A et al (2009) Dextran conjugated dendritic nanoconstructs as potential vectors for anti-cancer agent. Biomaterials 30:3588–3596
Calderon M et al (2010) Dendritic polyglycerols for biomedical applications. Adv Mater 22:190–218
Fleige E, Quadir MA, Haag R (2012) Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications. Adv Drug Deliv Rev 64:866–884
Lee CC et al (2006) A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas. Proc Natl Acad Sci 103:16649–16654
Calderón M et al (2011) Development of efficient acid cleavable multifunctional prodrugs derived from dendritic polyglycerol with a poly(ethylene glycol) shell. J Control Rel 151:295–301
Matyjaszewski K et al (2007) Macromolecular engineering: from precise macromolecular synthesis to macroscopic material properties and application. Wiley-VCH, Weinheim
Khandare J et al (2012) Multifunctional dendritic polymers in nanomedicine: opportunities and challenges. Chem Soc Rev 41:2824–2848
Wang JY, Casero RA Jr (2006) Polyamine cell signaling physiology, pharmacology, and cancer research. Humana Press, Totowa
Haensler J, Szoka FC Jr (1993) Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug Chem 4:372–379
Gebhart CL, Kabanov AV (2001) Evaluation of polyplexes as gene transfer agents. J Control Rel 73:401–416
Fischer W et al (2010) Dendritic polyglycerols with oligoamine shells show low toxicity and high transfection efficiency in vitro. Bioconjug Chem 21:1744–1752
Ofek P et al (2010) In vivo delivery of siRNA to tumors and their vasculature by novel dendritic nanocarriers. FASEB J 24:3122–3134
Wang B et al (2009) Anti-inflammatory and anti-oxidant activity of anionic dendrimer-N-acetyl cysteine conjugates in activated microglial cells. Int J Pharm 377:159–168
Papp J et al (2008) Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior. Chem Commun 44:5851–5853
Dernedde J et al (2010) Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation. Proc Natl Acad Sci U S A 107:19679–19684
Kensinger RD et al (2004) Synthesis of novel, multivalent glycodendrimers as ligands for HIV-1gp120. Bioconjug Chem 15:349–358
For detailed information. http://www.starpharma.com
Papp I et al (2011) Inhibition of influenza virus activity by multivalent glycoarchitectures with matched sizes. ChemBioChem 12:887–895
Nishiyama N et al (2009) Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanine. J Control Rel 133:245–251
Kobayashi H et al (2004) Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation. Clin Cancer Res 10:7712–7720
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Malhotra, S., Haag, R. (2015). Dendrimers and Hyperbranched Polymers in Medicine. In: Kobayashi, S., Müllen, K. (eds) Encyclopedia of Polymeric Nanomaterials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29648-2_17
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DOI: https://doi.org/10.1007/978-3-642-29648-2_17
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