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Efflux: How Bacteria Use Pumps to Control Their Microenvironment

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Antibiotic Resistance

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 211))

Abstract

Efflux pumps are a potent and clinically important cause of antibiotic resistance. The particular focus of this chapter is on the efflux pump as a target for antimicrobial therapy and the development of new antibacterials to address the efflux problem.

Tigecycline is an example of how old antibiotics, in this case tetracyclines, which have become substrates for efflux pumps, can be extensively modified to restore antimicrobial activity and clinical efficacy.

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Authors and Affiliations

  1. Faculty of Medicine, Imperial College, London, SW7 2AZ, UK

    E. David G. McIntosh

  2. Scientific Center for Children’s Health, Russian Academy of Medical Science, Moscow, Russia

    E. David G. McIntosh

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  1. E. David G. McIntosh
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Correspondence to E. David G. McIntosh .

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Editors and Affiliations

  1. , Div of Cellular and Molecular Medicine, St. George's, University of London, Cranmer Terrace, London, SW17 0RE, United Kingdom

    Anthony R.M. Coates

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McIntosh, E.D.G. (2012). Efflux: How Bacteria Use Pumps to Control Their Microenvironment. In: Coates, A. (eds) Antibiotic Resistance. Handbook of Experimental Pharmacology, vol 211. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28951-4_10

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