Definition
The tail nerve transection model is produced by partial injury of the nerve innervating the rodent tail. The model displays chronic neuropathic signs like mechanical allodynia, cold allodynia, and warm allodynia in the tail.
Characteristics
The tail nerve transection model is one of the peripheral neuropathic pain animal models. Peripheral nerve injury sometimes results in neuropathic pain. This type of pain is characterized by spontaneous burning pain accompanied by hyperalgesia and allodynia lasting variable times. Several experimental animal models for neuropathic pain, produced by a partial injury of the nerves supplying the rat hind paw, were developed by Bennett and Xie (1988), Seltzer et al. (1990), and Kim and Chung (1992), respectively. Although these models display clear signs of neuropathic pain, there are some inherent problems in...
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References
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Back, S.K., Kim, H.J., Na, H.S. (2013). Neuropathic Pain Model, Tail Nerve Transection Model. In: Gebhart, G.F., Schmidt, R.F. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28753-4_2684
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DOI: https://doi.org/10.1007/978-3-642-28753-4_2684
Publisher Name: Springer, Berlin, Heidelberg
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Online ISBN: 978-3-642-28753-4
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