Synonyms
Aging-associated gene 4 protein (AAG4); Apolipoprotein J (APO-J); Clu; Complement cytolysis inhibitor (CLI); Complement-associated protein SP-40 (SP-40); Ionizing radiation (IR)-induced protein-8 (XIP-8); Ku70-binding protein 1; NA1/NA2; Sulfated glycoprotein-2 (SGP-2); Testosterone-repressed prostate message 2 (TRPM-2)
Definition
Clusterin (CLU) is a heterodimeric glycoprotein with nearly ubiquitous tissue distribution which is involved in many biological processes such as sperm maturation, cell adhesion, tissue differentiation, membrane recycling, cell proliferation, lipid transportation, DNA repair, and cell death. CLU also plays important roles in many human diseases, among which are aging, neurodegenerative diseases, and cancer.
CLU was first described in 1983, but our understanding of its biological functions is still sketchy, mostly because of the contradictory results presented in the literature.
A general consensus concerning different functions of CLU inside and...
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References
Bettuzzi S, Pucci S (eds) (2009) Clusterin, part A and part B. Adv Cancer Res 104–105. http://www.sciencedirect.com/science/bookseries/0065230X/104, http://www.sciencedirect.com/science/bookseries/0065230X/105
Bonacini M, Coletta M, Ramazzina I, Naponelli V, Modernelli A, Davalli P, Bettuzzi S, Rizzi F (2015) Distinct promoters, subjected to epigenetic regulation, drive the expression of two clusterin mRNAs in prostate cancer cells. Biochim Biophys Acta 1849(1):44–54.
Jenne DE, Tschopp J (1989) Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. Proc Natl Acad Sci U S A 86(18):7123–7127. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298007/?tool=pubmed
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Trougakos IP, Djeu JY, Gonos ES, Boothman DA (2009) Advances and challenges in basic and translational research on clusterin. Cancer Res 69(2):403–406. http://cancerres.aacrjournals.org/content/69/2/403.long
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© 2014 Springer-Verlag Berlin Heidelberg
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Bettuzzi, S. (2014). Clusterin. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7128-6
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DOI: https://doi.org/10.1007/978-3-642-27841-9_7128-6
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
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