Definition
Adoptive T cell transfer is an approach to treat various types of diseases, particularly malignant tumors by intravenous injection of autologous T cells modified with or without a gene encoding a specific antigen receptor. T cells are usually isolated from the tumor tissues or peripheral blood mononuclear cells (PBMCs) of cancer patients, stimulated with tumor antigens or modified with a gene encoding a specific antigen receptor, then expanded in vitro to a large quantity before infusion back into the patient for treatment.
Characteristics
Adoptive T cell transfer is an approach of cancer immunotherapy, which has emerged as a novel and promising approach for treatment of cancer patients with advanced or refractory diseases, since traditional cancer treatments, including surgery, chemotherapy, and radiation therapy, have demonstrated very limited efficacy for patients with late-stage diseases. In...
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References
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© 2014 Springer-Verlag Berlin Heidelberg
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Wang, M. (2014). Adoptive T Cell Transfer. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7111-1
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DOI: https://doi.org/10.1007/978-3-642-27841-9_7111-1
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
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