Synonyms
Definition
Biological monitoring (i.e., biomonitoring) has conventionally been defined as “the periodic measurement of xenobiotic(s) or their metabolite(s) in accessible biological media for the comparison with an appropriate reference.” At present, a broader definition could be used that included effect biomarkers and biologically relevant dose, as well as biomarkers of susceptibility.
Characteristics
Biomonitoring is mainly aimed at:
Defining the existence of an occupational or environmental exposure
Quantifying the internal dose
Verifying that exposure limits are respected
The most commonly used matrices for biomonitoring are blood (and its components, e.g., serum and plasma) and urine.
Biological monitoring is complementary to the two other monitoring programs that are carried out to evaluate the health risk associated with exposure to pollutants, i.e., ambient monitoring and health surveillance. The basis of these monitoring programs is defined by...
References
Bonassi S, Znaor A, Ceppi M et al (2007) An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 28:625–631
Hirvonen A (2005) Gene-environment interaction and biological monitoring of environmental exposures. Toxicol Appl Pharmacol 207:329–335
Hirvonen A, Pelkonen O (2001) Measurement of drug metabolizing enzyme polymorphisms as indicators of susceptibility. In: Aitio A, Hayashi Y (eds) Biomarkers in risk assessment: validity and validation, Environmental health criteria, 222. World Health Organization, Geneva, pp 146–201
National Research Council (NRC) (1987) Biological markers in environmental health research. Environ Health Perspect 74:3–9
Shatzkin A, Freedman LS, Dorgan J (1997) Using and interpreting surrogate end-points in cancer research. In: Toniolo P, Boffetta P, Shuker DEG, Rothman N, Hulka B, Pearce N (eds) Application of biomarkers in cancer epidemiology. International Agency for Research on Cancer, Lyon, pp 265–271
Van Damme K, Casteleyn L (2003) Current scientific, ethical and social issues of biomonitoring in the European Union. Toxicol Lett 144:117–126
See Also
(2012) Adduct. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 43. doi:10.1007/978-3-642-16483-5_80
(2012) Biomarkers. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 408–409. doi:10.1007/978-3-642-16483-5_6601
(2012) Biotransformation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 415. doi:10.1007/978-3-642-16483-5_651
(2012) Cytogenetics. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 1050–1051. doi:10.1007/978-3-642-16483-5_1470
(2012) Genotype. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1540. doi:10.1007/978-3-642-16483-5_2396
(2012) Internal dose. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1897. doi:10.1007/978-3-642-16483-5_3105
(2012) Kinetic parameters. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1943. doi:10.1007/978-3-642-16483-5_3223
(2012) Metabolic capability. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2255. doi:10.1007/978-3-642-16483-5_3653
(2012) Metabolite. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2258. doi:10.1007/978-3-642-16483-5_3661
(2012) Phenotype. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2856. doi:10.1007/978-3-642-16483-5_4514
(2012) Standardization. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3501. doi:10.1007/978-3-642-16483-5_5480
(2012) Toxicology. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3734. doi:10.1007/978-3-642-16483-5_5873
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Hirvonen, A. (2014). Biomonitoring. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_643-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_643-2
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