Skip to main content
SpringerLink
Log in

ATM Protein

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 118 Accesses

Synonyms

Ataxia-telangiectasia, mutated; ATM

Definition

ATM is a large, homeostatic protein kinase with roles in various branches of cellular metabolism. ATM’s best characterized function is mobilizing a highly complex network of signaling pathways in response to double-strand breaks (DSBs) in the DNA. DSBs markedly enhance the protein kinase activity of ATM, which subsequently phosphorylates a multitude of substrates, typically key players in the numerous branches of the DNA damage response. ATM is missing or inactive in patients with the multisystem genetic disorder, ataxia telangiectasia (A-T), characterized by neurodegeneration, immune deficiency, genomic instability, sensitivity to ionizing radiation, and cancer predisposition. The cellular phenotype of cells from A-T patients includes premature senescence, chromosomal instability, extreme sensitivity to DSB-inducing agents such as ionizing radiation and radiomimetic chemicals, and defective activation of the extensive DSB...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Paull TT (2015) Mechanisms of ATM activation. Ann Rev Biochem 84:711–738

    Google Scholar 

  • Shiloh Y (2014) ATM: expanding roles as a chief guardian of genome stability. Exp Cell Res 329:154–161

    Article  CAS  PubMed  Google Scholar 

  • Shiloh Y, Ziv Y (2013) The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Cel Mol Biol 14:197–210

    Article  CAS  Google Scholar 

  • Thompson LH (2012) Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography. Mutat Res 751:158–246

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    Yosef Shiloh

Authors
  1. Yosef Shiloh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yosef Shiloh .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Shiloh, Y. (2014). ATM Protein. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_435-3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-27841-9_435-3

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation