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Chemically Induced Cell Transformation

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  • First Online:
Encyclopedia of Cancer

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Definition

Chemically induced cell transformation is the series of sequential steps that occur when mammalian cells are treated with Chemical Carcinogenesis and converted into tumor cells.

The intermediate cell phenotypes (cell properties) are acquired one at a time, including first cellular immortality, then morphological transformation (change in cell shape, leading to crisscrossing of cells in abnormal patterns), then anchorage independence (growth of cells as colonies or balls of cells in three-dimensional suspension of agar, without attachment to the plastic dishes cells are usually grown on), and finally neoplastic transformation (neoplastic cell transformation), or the ability of cells to form tumors when injected into nude (athymic) mice.

Characteristics

Normal Growth of Normal Cells

In the mammalian organism (warm-blooded animal), there are many types of cells. In general, these cell types are divided into (i) epithelial cells, which form the coverings of organs; (ii)...

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References

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See Also

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Author information

Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, and Department of Pathology, Cancer Research Laboratory, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Joseph R. Landolph Jr.

  2. Department of Molecular Pharmacology and Pharmaceutical Sciences, School of Pharmacy, Health Sciences Campus, University of Southern California, Los Angeles, CA, USA

    Joseph R. Landolph Jr.

Authors
  1. Joseph R. Landolph Jr.
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Correspondence to Joseph R. Landolph Jr. .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Landolph, J.R. (2015). Chemically Induced Cell Transformation. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1061-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1061-2

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  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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