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Test on Salivary Glands

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Drug Discovery and Evaluation: Pharmacological Assays

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Abstract

Symptoms of several human diseases are manifested as increased salivation (e.g., Parkinson’s disease) or decreased salivation (e.g., xerosis). Studies to find and to evaluate sialagogues, such as substance P and its synthetic derivatives, as well as to search for salivation inhibitors are necessary. Saliva excretion is greatly influenced by anesthetics. Wagner et al. (1991) proposed a simple method to study saliva secretion in conscious rats and to evaluate sialagogues and sialagogue antagonists.

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Authors and Affiliations

  1. Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Building H 821, 65926, Frankfurt, Germany

    Andreas W. Herling

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  1. Andreas W. Herling
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Correspondence to Andreas W. Herling .

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  1. Dieburg, Germany

    Franz J. Hock

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© 2014 Springer-Verlag Berlin Heidelberg

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Herling, A.W. (2014). Test on Salivary Glands. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27728-3_54-1

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  • DOI: https://doi.org/10.1007/978-3-642-27728-3_54-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27728-3

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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