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Assessment of Renal Function

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Drug Discovery and Evaluation: Pharmacological Assays

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Abstract

In the different parts of the kidney (proximal tubules, distal tubules, collecting ducts), fluid is reabsorbed and substances may be transported either from the tubule lumen to the blood side (reabsorption) or vice versa (secretion). Besides active transport and coupled transport systems, ion channels play an important role in the function of kidney cells. The various modes of the patch clamp technique (cell-attached, cell-excised, whole-cell mode) (Neher and Sakmann 1976; Hamill et al. 1981) allow the investigation of ion channels. In addition, the investigation of other electrogenic transport mechanisms, such as the sodium-coupled alanine transport, can be studied.

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  1. Non-Clinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc, 900 Ridgebury Road, 06877, Ridgefield, CT, USA

    Susan Emeigh Hart

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  1. Susan Emeigh Hart
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    Franz J. Hock

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Hart, S.E. (2015). Assessment of Renal Function. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27728-3_18-1

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