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Potential Allergens in Moisturizing Creams

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Treatment of Dry Skin Syndrome
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Abstract

Nowadays with the extensive use of cosmetics, allergic reactions are increasingly observed and a significant portion of them are due to moisturizers. Contact allergic reactions to cosmetics may be delayed-type reactions resulting in allergic and photoallergic contact dermatitis and more exceptionally immediate-type reactions, i.e., contact urticaria. Fragrances and preservatives are the most important contact allergens, but reactions may also occur to emulsifiers and other vehicle components, humectants, conditioning agents, plant extracts, antioxidants, sunscreens, and in fact, to any possible cosmetic ingredient. Patch testing remains the golden standard for diagnosing delayed-type reactions, although additional skin tests might be useful as well. Prick tests are generally used to diagnose allergic contact urticaria.

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References

  1. Goossens A (2011) Contact-allergic reactions to cosmetics. J Allergy 2011:467071. Epub 2011 Feb 21

    Google Scholar 

  2. Nardelli A, Drieghe J, Claes L, Boey L, Goossens A (2011) Fragrance allergens in ‘specific’ cosmetic products. Contact Dermatitis 64:212–219

    Article  PubMed  Google Scholar 

  3. Bruynzeel DP, Ferguson J, Andersen K, Gonçalo M, English J, Goossens A, Holzle E, Ibbotson SH, Lecha M, Lehmann P, Leonard F, Moseley H, Pigatto P, Tanew A, European Taskforce for Photopatch Testing (2004) Photopatch testing: a consensus methodology for Europe. J Eur Acad Dermatol Venereol 18:679–682

    Article  PubMed  CAS  Google Scholar 

  4. Goossens AE (2006) Sensitizing substances. In: Loden M, Maibach HI (eds) Dry skin and moisturizers: chemistry and function. CRC Press, Boca Raton, pp 515–522

    Google Scholar 

  5. de Groot AC, White IR, Flyvholm MA, Lensen G, Coenraads PJ (2010) Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics. Contact Dermatitis 62:2–17

    Article  PubMed  Google Scholar 

  6. de Groot A, White IR, Flyvholm MA, Lensen G, Coenraads PJ (2010) Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde. Contact Dermatitis 62:18–31

    Article  PubMed  Google Scholar 

  7. Yazar K, Johnsson S, Lind ML, Boman A, Lidén C (2011) Preservatives and fragrances in selected consumer-available cosmetics and detergents. Contact Dermatitis 64:265–272

    Article  PubMed  CAS  Google Scholar 

  8. Brown VL, Orton DI (2005) Two cases of facial dermatitis due to chlorphenesin in cosmetics. Contact Dermatitis 52:48–49

    Article  PubMed  CAS  Google Scholar 

  9. Wakelin SH, White IR (1997) Dermatitis from chlorphenesin in a facial cosmetic. Contact Dermatitis 37:138–139

    Article  PubMed  CAS  Google Scholar 

  10. Thormann H, Kollander M, Andersen KE (2009) Allergic contact dermatitis from dichlorobenzyl alcohol in a patient with multiple contact allergies. Contact Dermatitis 60:295–296

    Article  PubMed  CAS  Google Scholar 

  11. Katsuyama M, Kobayashi Y, Ichikawa H, Mizuno A, Miyachi Y, Matsunaga K, Kawashima M (2005) A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin. J Dermatol Sci 38:207–213

    Article  PubMed  Google Scholar 

  12. Gilpin S, Maibach H (2010) Allergic contact dermatitis caused by farnesol: clinical relevance. Cutan Ocul Toxicol 29:278–287

    Article  PubMed  CAS  Google Scholar 

  13. Schnuch A, Lessmann H, Geier J, Uter W (2011) Contact allergy to preservatives. Analysis of IVDK data 1996 – 2009. Br J Dermatol 164:1316–1325. doi:10.1111/j.1365-2133.2011.10253.x, Epub ahead of print

    Article  PubMed  CAS  Google Scholar 

  14. Tosti A, Guerra L, Bardazzi F, Gasparri F (1991) Euxyl K 400: a new sensitizer in cosmetics. Contact Dermatitis 25:89–93

    Article  PubMed  CAS  Google Scholar 

  15. García-Gavín J, Vansina S, Kerre S, Naert A, Goossens A (2010) Methylisothiazolinone, an emerging allergen in cosmetics? Contact Dermatitis 63:96–101

    Article  PubMed  Google Scholar 

  16. Ackermann L, Aalto-Korte K, Alanko K, Hasan T, Jolanki R, Lammintausta K, Lauerma A, Laukkanen A, Liippo J, Riekki R, Vuorela AM, Rantanen T (2011) Contact sensitization to methylisothiazolinone in Finland – a multicentre study. Contact Dermatitis 64:49–53

    Article  PubMed  CAS  Google Scholar 

  17. Cashman AL, Warshaw EM (2005) Parabens: a review of epidemiology, structure, allergenicity, and hormonal properties. Dermatitis 16:57–66

    Article  PubMed  Google Scholar 

  18. Lovell CR, White IR, Boyle J (1984) Contact dermatitis from phenoxyethanol in aqueous cream BP. Contact Dermatitis 11:187

    Article  PubMed  CAS  Google Scholar 

  19. Raison-Peyron N, Meynadier JM, Meynadier J (2000) Sorbic acid: an unusual cause of systemic contact dermatitis in an infant. Contact Dermatitis 43:247–248

    PubMed  CAS  Google Scholar 

  20. Patrizi A, Orlandi C, Vincenzi C, Bardazzi F (1999) Allergic contact dermatitis caused by sorbic acid: rare occurrence. Am J Contact Dermat 10:52

    Article  PubMed  CAS  Google Scholar 

  21. Goossens A, Decraene T, Platteaux N, Nardelli A, Rasschaert V (2003) Glucosides as unexpected allergens in cosmetics. Contact Dermatitis 48:164–166

    Article  PubMed  CAS  Google Scholar 

  22. Kiec-Swierczynska M, Krecisz B, Swierczynska-Machura D (2005) Photoallergic and allergic reaction to 2-hydroxy-4-methoxybenzophenone (sunscreen) and allergy to cetyl alcohol in cosmetic cream. Contact Dermatitis 53:170–171

    Article  PubMed  Google Scholar 

  23. Pascoe D, Moreau L, Sasseville D (2010) Emergent and unusual allergens in cosmetics. Dermatitis 21:127–137

    PubMed  CAS  Google Scholar 

  24. Blondeel A (2003) Contact allergy to the mild surfactant decylglucoside. Contact Dermatitis 49:304–305

    Article  PubMed  CAS  Google Scholar 

  25. Andersen KE, Goossens A (2006) Decyl glucoside contact allergy from a sunscreen product. Contact Dermatitis 54:349–350

    Article  PubMed  Google Scholar 

  26. Lucidarme N, Aerts O, Roelandts R, Goossens A (2008) Hydroxyethyl acrylate: a potential allergen in cosmetic creams? Contact Dermatitis 59:321–322

    Article  PubMed  Google Scholar 

  27. Goossens A, Verbruggen K, Cattaert N, Boey L (2008) New cosmetic allergens: isononyl isononanoate and trioleyl phosphate. Contact Dermatitis 59:320–321

    Article  PubMed  CAS  Google Scholar 

  28. Bharati A, King CM (2004) Allergic contact dermatitis from isohexadecane and isopropyl myristate. Contact Dermatitis 50:256–257

    Article  PubMed  CAS  Google Scholar 

  29. Lee B, Warshaw E (2008) Lanolin allergy: history, epidemiology, responsible allergens, and management. Dermatitis 19:63–72

    PubMed  CAS  Google Scholar 

  30. Warshaw EM, Nelsen DD, Maibach HI, Marks JG, Zug KA, Taylor JS, Rietschel RL, Fowler JF, Mathias CG, Pratt MD, Sasseville D, Storrs FJ, Belsito DV, DeLeo VA (2009) Positive patch test reactions to lanolin: cross-sectional data from the North American contact dermatitis group, 1994 to 2006. Dermatits 20:79–88

    CAS  Google Scholar 

  31. Goossens A, Armingaud P, Avenel-Audran M, Begon-Bagdassarian I, Constandt L, Giordano-Labadie F, Girardin P, Coz CJ, Milpied-Homsi B, Nootens C, Pecquet C, Tennstedt D, Vanhecke E (2002) An epidemic of allergic contact dermatitis due to epilating products. Contact Dermatitis 47:67–70

    Article  PubMed  CAS  Google Scholar 

  32. Le Coz CJ, Heid E (2001) Allergic contact dermatitis from methoxy PEG-17/dodecyl glycol copolymer (Elfacos OW 100). Contact Dermatitis 44:308–309

    PubMed  Google Scholar 

  33. Warshaw EM, Botto NC, Maibach HI, Fowler JF Jr, Rietschel RL, Zug KA, Belsito DV, Taylor JS, DeLeo VA, Pratt MD, Sasseville D, Storrs FJ, Marks JG Jr, Mathias CG (2009) Positive patch-test reactions to propylene glycol: a retrospective cross-sectional analysis from the North American Contact Dermatitis Group, 1996 to 2006. Dermatitis 20:14–20

    PubMed  Google Scholar 

  34. Goossens A, Baret I, Swevers A (2011) Allergic contact dermatitis caused by tetrahydroxypropyl ethylenediamine in cosmetic products. Contact Dermatitis 64:161–164

    Article  PubMed  Google Scholar 

  35. Pereira F, Cunha H, Dias M (1997) Contact dermatitis due to emulsifiers. Contact Dermatitis 36:114

    Article  PubMed  CAS  Google Scholar 

  36. Russell K, Jacob SE (2010) Bisabolol. Dermatitis 21:57–58

    PubMed  Google Scholar 

  37. Wilkinson SM, Hausen BM, Beck MH (1995) Allergic contact dermatitis from plant extracts in a cosmetic. Contact Dermatitis 33:58–59

    Article  PubMed  CAS  Google Scholar 

  38. Linsen G, Goossens A (2002) Allergic contact dermatitis from ethylhexylglycerin. Contact Dermatitis 47:169

    Article  PubMed  CAS  Google Scholar 

  39. Roberts H, Williams J, Tate B (2006) Allergic contact dermatitis to panthenol and cocamidopropyl PG dimonium chloride phosphate in a facial hydrating lotion. Contact Dermatitis 55:369–370

    Article  PubMed  Google Scholar 

  40. Stables GI, Wilkinson SM (1998) Allergic contact dermatitis due to panthenol. Contact Dermatitis 38:236–237

    Article  PubMed  CAS  Google Scholar 

  41. Ting PT, Silver S (2004) Allergic contact dermatitis to propolis. J Drugs Dermatol 3:685–686

    PubMed  Google Scholar 

  42. Paulsen E, Chistensen LP, Andersen KE (2008) Cosmetics and herbal remedies with Compositae plant extracts – are they tolerated by Compositae-allergic patients? Contact Dermatitis 58:15–23

    Article  PubMed  Google Scholar 

  43. Vansina S, Debilde D, Morren MA, Goossens A (2010) Sensitizing oat extracts in cosmetic creams: is there an alternative? Contact Dermatitis 63:169–171

    PubMed  Google Scholar 

  44. Fritz TM, Burg G, Krasovec M (2001) Allergic contact dermatitis to cosmetics containing Melaleuca alternifolia (tea tree oil). Ann Dermatol Venereol 128:123–126

    PubMed  CAS  Google Scholar 

  45. Swinnen I, Goossens A (2011) Allergic contact dermatitis caused by ascorbyl tetraisopalmitate. Contact Dermatitis 64:241–242

    Article  PubMed  Google Scholar 

  46. Foti C, Bonamonte D, Cassano N, Conserva A, Vena GA (2010) Allergic contact dermatitis to propyl gallate and pentylene glycol in an emollient cream. Australas J Dermatol 51:147–148

    Article  PubMed  Google Scholar 

  47. Malik MM, Hegarty MA, Bourke JF (2007) Sodium metabisulfite – a marker for cosmetic allergy? Contact Dermatitis 56:241–242

    Article  PubMed  Google Scholar 

  48. Manzano D, Aguirre A, Gardeazabal J, Eizaguirre X, Díaz Pérez JL (1994) Allergic contact dermatitis from tocopheryl acetate (vitamin E) and retinol palmitate (vitamin A) in a moisturizing cream. Contact Dermatitis 31:324

    Article  PubMed  CAS  Google Scholar 

  49. Silva R, Almeida LM, Brandão FM (1995) Photoallergy to oxybenzone in cosmetic creams. Contact Dermatitis 32:176

    Article  PubMed  CAS  Google Scholar 

  50. González-Pérez R, Trébol I, García-Río I, Arregui MA, Soloeta R (2007) Allergic contact dermatitis from methylene-bis-benzotriazolyl tetramethylbutylphenol (Tinosorb M). Contact Dermatitis 56:121

    Article  PubMed  Google Scholar 

  51. Frosch PJ, Pilz B, Andersen KE et al (1995) Patch testing with fragrances: results of a multi-center study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes. Contact Dermatitis 33:333–342

    Article  PubMed  CAS  Google Scholar 

  52. Frosch PJ, Johansen JD, Menné T et al (1999) Lyral is an important sensitizer in patients sensitive to fragrances. Br J Dermatol 141:1076–1083

    Article  PubMed  CAS  Google Scholar 

  53. Matura M, Goossens A, Bordalo O, Garcia-Bravo B, Magnusson K, Wrangsjo K, Karlberg AT (2003) Patch testing with oxidized R- (+)-limonene and its hydroperoxide fraction. Contact Dermatitis 49:15–21

    Article  PubMed  CAS  Google Scholar 

  54. Sköld M, Börje A, Matura M, Karlberg AT (2002) Studies on the autoxidation and sensitizing capacity of the fragrance chemical linalool, identifying a linalool hydroperoxide. Contact Dermatitis 46:267–272

    Article  PubMed  Google Scholar 

  55. Johansen JD, Bernard G, Giménez-Arnau E et al (2006) Comparison of elicitation potential of chloroatranol and atranol – 2 allergens in oak moss absolute. Contact Dermatitis 54:192–195

    Article  PubMed  CAS  Google Scholar 

  56. Paulsen E, Andersen KE (2005) Colophonium and Compositae mix as markers of fragrance allergy: cross-reactivity between fragrance terpenes, colophonium and compositae plant extracts. Contact Dermatitis 53:285–291

    Article  PubMed  CAS  Google Scholar 

  57. Thyssen JP, Engkilde K, Lundov MD, Carlsen BC, Menné T, Johansen JD (2010) Temporal trends of preservative allergy in Denmark (1985–2008). Contact Dermatitis 62:102–108

    Article  PubMed  Google Scholar 

  58. Lundov MD, Johansen JD, Carlsen BC, Engkilde K, Menné T, Thyssen JP (2010) Formaldehyde exposure and patterns of concomitant contact allergy to formaldehyde and formaldehyde-releasers. Contact Dermatitis 63:31–36

    Article  PubMed  CAS  Google Scholar 

  59. Emeis D, de Groot AC, Brinkmann J (2010) Determination of formaldehyde in formaldehyde-releaser patch test preparations. Contact Dermatitis 63:57–62

    Article  PubMed  CAS  Google Scholar 

  60. Flyvholm M-A, Andersen P (1993) Identification of formaldehyde releasers and occurrence of formaldehyde and formaldehyde releasers in registered chemical products. Am J Ind Med 24:533–552

    Article  PubMed  CAS  Google Scholar 

  61. Kireche M, Gimenez-Arnau E, Lepoittevin JP (2010) Preservatives in cosmetics: reactivity of allergenic formaldehyde-releasers towards amino acids through breakdown products other than formaldehyde. Contact Dermatitis 63:192–202

    Article  PubMed  CAS  Google Scholar 

  62. García-Gavín J, González-Vilas D, Fernández-Redondo V, Toribo J (2010) Allergic contact dermatitis in a girl due to several cosmetics containing diazolidinyl-urea or imidazolidinyl-urea. Contact Dermatitis 63:49–50

    Article  PubMed  Google Scholar 

  63. Lehmann SV, Hoeck U, Breinholdt J, Olsen CE, Kreilgaard B (2006) Characterization and chemistry of imidazolidinyl urea and diazolidinyl urea. Contact Dermatitis 54:50–58

    Article  PubMed  CAS  Google Scholar 

  64. Lundov MD, Moesby L, Zachariae C, Johansen JD (2009) Contamination versus preservation of cosmetics: a review on legislation, usage, infections, and contact allergy. Contact Dermatitis 60:70–78

    Article  PubMed  Google Scholar 

  65. Revuz J (2009) Long live parabens. Ann Dermatol Venereol 136:403–404

    Article  PubMed  CAS  Google Scholar 

  66. European-Communities (2007) Directive EU 2007/­17/EC 22 March 2007

    Google Scholar 

  67. Lotery H, Kirk S, Beck M, Burova E, Crone M, Curley R, Downs A, Hill G, Horne H, Iftikhar N, Lovell C, Malanin K, Orton D, Powell S, Sansom J, Sonnex T, Todd D, Tucker S, Wilkinson M, Haworth A (2007) Dicaprylyl maleate. Contact Dermatitis 57:169–172

    Article  PubMed  CAS  Google Scholar 

  68. Sugiura M, Hayakawa R, Kato Y, Sugiura K, Hashimoto R, Shamoto M (2001) Results of patch testing with 1,3-butylene glycol from 1994 to 1999. Environ Dermatol 8:1–5

    Google Scholar 

  69. Gallo R, Viglizzo G, Vecchio F, Parodi A (2003) Allergic contact dermatitis from pentylene glycol in an emollient cream, with possible co-sensitization to resveratrol. Contact Dermatitis 48:176–177

    Article  PubMed  CAS  Google Scholar 

  70. Gallo R, Sacco DD, Ghigliotti G (2004) Allergic contact dermatitis from VP/eicosene copolymer (Ganex V-220) in an emollient cream. Contact Dermatitis 50:261

    Article  PubMed  CAS  Google Scholar 

  71. Kügler K, Mydlach B, Frosch PJ (2009) Contact allergy from alkyl rhamnoside-C5. Contact Dermatitis 61:352–353

    Article  PubMed  Google Scholar 

  72. Brasch J, Lipowsky F, Kreiselmaier I (2008) Allergic contact dermatitis to phytantriol. Contact Dermatitis 59:251–252

    Article  PubMed  CAS  Google Scholar 

  73. Kiken DA, Cohen DE (2002) Contact dermatitis to botanical extracts. Am J Contact Dermat 13:148–152

    Article  PubMed  Google Scholar 

  74. Thomson KF, Wilkinson SM (2003) Allergic contact dermatitis to plant extracts in patients with cosmetic dermatitis. Br J Dermatol 142:84–88

    Article  Google Scholar 

  75. Pazzaglia M, Jorizzo M, Parente G, Tosti A (2000) Allergic contact dermatitis due to avena extract. Contact Dermatitis 42:364

    PubMed  CAS  Google Scholar 

  76. Sanchez-Pérez J, Sanz T, García-Díez A (2000) Allergic contact dermatitis from hydrolyzed wheat protein in a cosmetic cream. Contact Dermatitis 42:360

    PubMed  Google Scholar 

  77. Shaffrali FC, Gawkrodger DJ (2001) Contact dermatitis from soybean extract in a cosmetic cream. Contact Dermatitis 44:51–52

    Article  PubMed  CAS  Google Scholar 

  78. Boussault P, Léauté-Labrèze C, Saubusse E, Maurice-Tison S, Perromat M, Roul S, Sarrat A, Taïeb A, Boralevi F (2007) Oat sensitization in children with atopic dermatitis: prevalence, risks and associated factors. Allergy 62:1251–1256

    Article  PubMed  CAS  Google Scholar 

  79. Goujon-Henry C, Hennino A, Nicolas J-F (2008) Do we have to recommend not using oat-containing emollients in children with atopic dermatitis? Allergy 63:781–782

    Article  PubMed  CAS  Google Scholar 

  80. Rancé F, Dargassies J, Dupuy P, Schmitt AM, Gúerin L, Dutau G (2001) Faut-il contre-indiquer l’utilisation des émollients à base d’avoine chez l’enfant atopique? Rev Fr Allergol Immunol Clin 41:477–483

    Google Scholar 

  81. Paulsen E, Christensen LP, Fretté XC, Andersen KE (2010) Patch test reactivity to feverfew-containing creams in feverfew-allergic patients. Contact Dermatitis 63:146–150

    PubMed  CAS  Google Scholar 

  82. Belhadjali H, Giordano-Labadie F, Bazex J (2001) Contact dermatitis from vitamin C in a cosmetic anti-aging cream. Contact Dermatitis 45:317

    Article  PubMed  CAS  Google Scholar 

  83. Sasseville D, Moreau L, Al-Sowaidi M (2007) Allergic contact dermatitis to idebenone used as an antioxidant in an anti-wrinkle cream. Contact Dermatitis 56:117

    Article  PubMed  CAS  Google Scholar 

  84. Natkunarajah J, Ostlere L (2008) Allergic contact dermatitis to idebenone in an over-the-counter anti-ageing cream. Contact Dermatitis 58:239

    Article  PubMed  CAS  Google Scholar 

  85. Fleming JD, White JM, White IR (2008) Allergic contact dermatitis to hydroxydecyl ubiquinone: a newly described contact allergen in cosmetics. Contact Dermatitis 58:245

    Article  PubMed  CAS  Google Scholar 

  86. Avenel-Audran M, Dutartre H, Goossens A, Jeanmougin M, Comte C, Bernier C, Benkalfate L, Michel M, Ferrier-Lebouëdec MC, Vigan M, Bourrain JL, Outtas O, Peyron JL, Martin L (2010) Octocrylene, an emerging photoallergen. Arch Dermatol 146:753–757

    Article  PubMed  Google Scholar 

  87. Karlsson I, Vanden Broecke K, Mårtensson J, Goossens A, Börje A (2011) Clinical and experimental studies of octocrylene’s allergenic potency. Contact Dermatitis. doi:10.1111/j.1600-0536.2011.01899.x, Epub ahead of print

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Travassos, A.R., Goossens, A. (2012). Potential Allergens in Moisturizing Creams. In: Lodén, M., Maibach, H. (eds) Treatment of Dry Skin Syndrome. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27606-4_24

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