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Transfusion-related Pulmonary Complications

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Annual Update in Intensive Care and Emergency Medicine 2012

Part of the book series: Annual Update in Intensive Care and Emergency Medicine ((AUICEM,volume 2012))

Abstract

Physicians have long recognized, though incompletely understood, the respiratory symptoms their patients may manifest after receiving a blood product transfusion [1, 2]. Today, two distinct pulmonary transfusion reactions are recognized as the likely etiology. Although both share a similar clinical phenotype of pulmonary edema and hypoxemic respiratory insufficiency, each have different management schemes and preventative strategies [3–6]. One reaction, called transfusionrelated acute lung injury (TRALI) is a life-threatening complication marked by acute inflammation and injury to the pulmonary parenchyma and vasculature with resultant alveolar flooding. The second, transfusion-associated circulatory overload (TACO) results from the compensatory capacity of the cardiovascular system being overwhelmed by an increase in intravascular volume. This overloaded state manifests as respiratory distress from hydrostatic pulmonary edema.

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Authors
  1. A. D. Goldberg
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  2. L. Clifford
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  3. D. J. Kor
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Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head) (Head)

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Goldberg, A.D., Clifford, L., Kor, D.J. (2012). Transfusion-related Pulmonary Complications. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2012. Annual Update in Intensive Care and Emergency Medicine, vol 2012. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25716-2_41

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  • DOI: https://doi.org/10.1007/978-3-642-25716-2_41

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